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How bioinformatics led one scientist home to Lithuania

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Portrait of Juozas Gordevicius giving a lecture, holding a microphone.

Juozas Gordevičius says that Lithuania has a large pool of scientific talent.Credit: Asta Balčiūnaitė-Gordevičienė

Voices from Lithuania

In May, Lithuania marks 20 years of European Union membership. The Baltic country is keen to develop its global presence in the life-science and biotechnology sectors by retaining home-grown talent, persuading scientists working abroad to return to the country, and attracting researchers from other nations. Nature spoke to three scientists who have chosen to develop their careers in Lithuania. Here, Nature talks to Juozas Gordevičius, founder of Vugene, a bioinformatics data-science company in Vilnius.

I was born nine years before Lithuania gained independence from the Soviet Union in 1990. I was part of the first generation that did not have compulsory Russian lessons at school. In 2004 — the year that Lithuania joined the European Union — I undertook a master’s degree in computer science at the Free University of Bozen–Bolzano in Italy, and stayed there for my PhD, during which I worked for the former online-news-aggregation company Thoora. The news service worked out the most important events in a given time period, and the mathematics and algorithms that it used turned out to be very relevant in bioinformatics.

One evening, I was out drinking beer with some other Lithuanians in Toronto, Canada, where Thoora was based. One of them was Arturas Petronis at the University of Toronto, who studies genetics. I explained that I was really into computer science, but that I didn’t want to work for Google or the like. Instead, I wanted to do something that contributes to human health (my older brother and sister are both physicians). He said, try bioinformatics, it’s the future.

My first foray into health was in 2011, as a visiting postdoc working with Petronis at the Centre for Addiction and Mental Health in Toronto, Canada’s largest mental-health teaching hospital. I worked there as a biological data-science consultant and travelled back and forth between Canada and Lithuania for years because that year I was also appointed as a bioinformatics researcher at Vilnius University’s Institute of Mathematics and Informatics. I was literally working night and day.

A move to business

In 2019, I joined the Van Andel Institute, an independent biomedical research institute in Grand Rapids, Michigan, as a bioinformatics scientist. I realized that the work of a bioinformatician is very limited in academia. Universities have lots of people who do the experiments and typically hire only one bioinformatician. You have to do everything in the lab: run the servers that do the computation, manage the data and write the code. Every project becomes very lengthy. It can take a year or two to arrive at a result that is publishable. It’s interesting in the beginning, but after a while, you feel lonely. I thought that if I had a team of people working with me, and I could optimize these processes, it would be much faster.

So, I started a company in Grand Rapids in 2021 to do just that. I called it Vugene.

Having a base in the United States made it possible for the institutes that I was working with to have a contract with Vugene. I certainly didn’t have to explain where Lithuania is — it was a gate opener.

By this time, the COVID-19 pandemic had hit and I had decided to return to Lithuania with my wife to build the company there. At first, I was doing everything alone.

Vugene in Lithuania is based at the Sunrise Valley Science and Technology Park in Vilnius, close to the University’s Life Sciences Center, with a second office in Kaunas, Lithuania’s second city. The company offers bioinformatics data science as a service, specializing in biomedical research, bioinformatics, machine learning and software engineering.

Our clients include research laboratories looking at the origins, causes, treatments and diagnostics of various complex disorders, such as cancers or neurodegenerative diseases. Vugene manages large data sets, performs quality control, processes raw data and does statistical analysis.

Work and study

It has always been my dream to do something that could be used in medical practice. Vugene is concentrating on early diagnostics. The company works a lot in the neurodegeneration field, mostly sequencing epigenomic data sets. Currently, 30 projects are running in parallel.

The first hire was a big step. I am very lucky with the people who joined me. Milda Milčiūtė, then a third-year genetics student at Vilnius, came first, in 2021. I became her supervisor for her dissertation and we worked together on her thesis on the expression of endogenous retroviruses in Parkinson’s disease. She worked part-time for Vugene, programming and building models. She’s now doing her master’s while working here.

Working at a company while studying happens in Lithuania a lot. I’ve taken on four students — three undergraduates and one doing a PhD. This is in addition to two postdocs, and a chief executive and a designer.

I think the biotech and life-sciences community in Lithuania is special. We have the right ingredients: a long-standing history in the life sciences; very good infrastructure in terms of computer science and the Internet; and a significant pool of talent owing to the high quality of education. Students going into these fields are the highest achievers. They have the desire to do their best, and to go and see the world as previous generations did. We are also a small country, it’s easy to get what you need, and the government is supportive. Now, for us as bioinformaticians, the task is to put all of this together.

Outside work, life is good here — we have fast Internet, free education and good health care as standard. On top of that, many people have a strong desire to do good things. The country is changing very quickly and for the better, so it feels great to be here.

Sailing has always been very important to me, and it’s very popular in Lithuania. It’s a good antidote to my work. In a race, I have to concentrate and stay alert for an extended period of time under extreme physical stress — it takes 100% of my mental capacity, there’s no time for anything else.

Jacqui Thornton’s travel and accommodation were provided by Go Vilnius, a tourism and development agency.

This interview has been edited for length and clarity.

This article is part of Nature Spotlight: Lithuania, an editorially independent supplement. Advertisers have no influence over the content.

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Finally! After a 7-year wait, this monitor could well be the best pro-level 8K display ever — will Asus be able to break the curse of failed 8K monitor launches with the PA32KCX Mini LED pro screen?

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Mini LEDs are typically found in gaming monitors. Unlike LCD backlights, they offer a broad contrast range, with deeper, near-OLED quality levels of black, that enrich and enhance the dynamism of both SDR and HDR content.

Asus has brought Mini LED technology to the ultra-high-end business monitor market for the first time with its new 32-inch ProArt Display PA32KCX. The 8K screen (that’s a whopping 7,680 x 4,320 pixels – 275 PPI), is aimed at professional photographers, video editors and graphics artists.

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Turns out the viral ‘Air Head’ Sora video wasn’t purely the work of AI we were led to believe

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A new interview with the director behind the viral Sora clip Air Head has revealed that AI played a smaller part in its production than was originally claimed. 

Revealed by Patrick Cederberg (who did the post-production for the viral video) in an interview with Fxguide, it has now been confirmed that OpenAI‘s text-to-video program was far from the only force involved in its production. The 1-minute and 21-second clip was made with a combination of traditional filmmaking techniques and post-production editing to achieve the look of the final picture.

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‘A whole new generation of displays’: researchers develop RGB LED out of miracle material perovskite, paving the way for self sensing, solar powered displays — but its hour-long service life needs to be improved first

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The majority of personal gadgets feature LCD and OLED screens, but most just show information. To make these screens do more – like detecting touch or changing light levels – they need additional sensors. Researchers at Linköping University (LiU) in Sweden have invented a new kind of screen where all these sensor functions are built right into the screen’s LEDs.

The breakthrough in display technology was achieved by crafting RGB LED displays from a “miracle” material known as perovskite. This development marks a potential revolution for future screens of smartphones, computers, and tablets.

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Life Style

Are women in research being led up the garden path?

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Erin Zimmerman at the Guyana waterfall.

In Unrooted, botanist Erin Zimmerman shares her struggle to balance research and family.Credit: Kenneth Wurdack

Unrooted: Botany, Motherhood, and the Fight to Save An Old Science Erin Zimmerman Melville House (2024)

Nineteenth-century English suffragist Lydia Ernestine Becker, a lifelong advocate for women’s right to vote, was also an accomplished botanist who discovered a peculiar hermaphrodite flower. She found that the female flowers of red campion, Lychnis diurna (now called Silene dioica), develop stamens — the pollen-producing male part of a flower — when infected with a fungus. She expounded on these ‘curious characteristics’ in correspondence with Charles Darwin, and published a paper on her findings in 1869 (L. Becker J. Bot. 7, 291–292; 1869).

“Becker’s research led her to consider that the seemingly fixed categories of male and female might not be as immutable as they first seemed,” notes evolutionary biologist Erin Zimmerman in her moving memoir of botany and motherhood, Unrooted. Becker concluded that girls and women were lagging behind only because they received less education than boys and men. Her ideas caused a backlash, and she was ridiculed by press critics — some even implied that she was a hermaphrodite herself.

Uncertainties in science and in life

In some ways, Becker’s story foreshadows that of Zimmerman. Women in science still struggle to succeed in academia in the face of ingrained sexism. In her book, Zimmerman describes her determination to pursue a career in her beloved field of botany. She travels from Montreal, Canada, to the Royal Botanic Gardens, Kew, in London, and then to the Guyanese rainforest, in search of a group of tropical trees and shrubs known as Dialiinae (now called Dialioideae) — one of the earliest evolutionary branches of the legume family. In Guyana, she encounters an enormous anaconda and a terrier-size spotted rodent called a labba (Cuniculus paca). She climbs part-way up 60-metre-tall trees, battling her dread of falling as well as angry insects.

Perhaps Zimmerman’s most powerful fear, however, the difficulty of combining her career with motherhood. She tells her boyfriend Eric that she would “certainly not be having children”, and her concerns over parenthood are not unfounded. In the United States, 43% of women with full-time jobs in science leave the sector or take on part-time roles after having their first child (E. A. Cech and M. Blair-Loy Proc. Natl Acad. Sci. USA 116, 4182–4187; 2019). By contrast, only 23% of new fathers leave or reduce their hours.

The author experiences this herself, and she finds parallels between the obstacles faced by women in science and global threats to plants. According to the 2023 State of the World’s Plants and Fungi report (see go.nature.com/3xardd7), 45% of all known flowering plant species are at risk of extinction — a percentage eerily similar to that of women leaving full-time research.

Illustration from Unrooted. Monstera deliciosa, pen and ink.

Zimmerman’s botanical sketches, such as this one of Monstera deliciosa, dot the book.Credit: Melville House Publishing

Zimmerman’s field is hardly secure: her PhD project involved carefully dissecting decades-old, dried plant specimens stored in herbaria and extracting DNA from the samples. These collections are important for assessing extinction risks, yet they are themselves under threat. “Old and venerable collections housing many priceless specimens look to some funding bodies like dusty old money pits,” she writes. In February, Duke University in Durham, North Carolina, announced the closure of its 100-year-old herbarium, which houses 825,000 specimens, saying that the collection had become “too expensive to maintain” (see go.nature.com/4cnbyjm).

Nevertheless, Zimmerman persisted. Her plants had become beloved children, absorbing her attention. Lists of specialized terms such as leaf shapes “read like an arcane spell book”: “Ovate. Lanceolate. Cordate. Falcate. Orbicular. Cuneate.” She draws plant specimens in meticulous detail, and these lovely illustrations dot the pages of her book.

But her devotion to her research becomes an obsession, isolating her. And as she plots her path, she realizes how tenuous her dream of tenure is: there are too few faculty positions.

A different future

Despite the pressures, Zimmerman manages to maintain a life outside the laboratory: soon after her doctoral defence — a moment she has dreamed of for years — she and Eric marry in the barn of her childhood home in Ontario. One month later, she discovers she is pregnant. In the middle of her pregnancy, she lands a postdoc position at a Canadian government agricultural facility.

This is where her personal and professional lives collide. Overworked, in pain, accused of having ‘brain fog’, dismissed for her concerns about working in a pesticide-sprayed greenhouse while pregnant and, later, longing for her infant daughter, Zimmerman decides to quit. Her supervisor’s reaction is appalling: “‘I’m never going to hire a pregnant woman, or one who’s going to get pregnant, again,’ he spat. ‘You were a terrible investment’.”

This moment of misogyny leads Zimmerman to reconsider the landscape of science. Women are often derided for their reproductive choices, yet men have children, too. The highly praised Darwin, for example, had ten children with his cousin, Emma Wedgwood. Men who have become scientific heroes often dedicated all their waking hours to their research, while women — including their wives or, in the case of wealthy men, nannies — raised their children.

To slow “the haemorrhage of women” from the hyper-competitive world of research, we need better policies, Zimmerman writes. These should include protected parental leave, flexibility for new mothers to work from home, designated breast-pumping spaces (rather than the mildewed shower stall Zimmerman was forced to use) and childcare facilities at conferences, so that women don’t miss out on networking and hiring opportunities.

After departing from research, Zimmerman switched to science journalism, for which we should be grateful, for she writes beautifully. In some ways, her decision echoes Becker’s, who published her 1864 book Botany for Novices under just her initials (L.E.B.) and then left the field to dedicate herself to women’s activism. Now, 160 years later, Zimmerman can tell her story, under her full name. That’s progress.

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Entertainment

Roku releases its line of premium-ish TVs with Mini LED backlighting

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Roku has released a line of TVs after first . These televisions are packed with tech, with the standout feature being Mini LED backlighting for better brightness and contrast. The 4K TVs also boast QLED panels, HDR10+, Dolby Vision and a responsive refresh rate of 120Hz. The company’s calling them the “ultimate TVs” for streaming.

To that end, the quad-core processor should allow for snappier menu navigation and for apps to launch quickly, so you can spend less time waiting on a load screen and more time binging Hulu’s Shogun while scarfing down a big bowl of popcorn. They’re also Wi-Fi 6 capable, which comes in handy when streaming 4K content.

On the audio side of things, the Pro Series models include side-firing Dolby Atmos speakers for a “wide, cinematic sound.” The TVs integrate nicely with wireless soundbars, speakers and subwoofers, in addition to wired variants. Each model also features Bluetooth for connecting wireless headphones, to prevent spoilers from seeping into every corner of the house. They come with a refreshed remote control that includes motion-activated backlit buttons, USB-C charging and new shortcut options.

The Pro Series TVs feature a new neural processing unit (NPU) that allows for some nifty OS features. Smart Picture Max uses AI to automatically adjust the best picture mode for a particular piece of content, refining the color, sharpness and motion as required. This carries over to brightness, which also automatically adjusts depending on room lighting.

While Smart Picture Max might be tied to the Pro Series line of TVs, due to the updated NPU, there are more OS features coming to all Roku panels. The company’s televisions will soon get something called Backdrops, which are basically just fancy screensavers pulled from a wide catalog of popular artwork or via uploaded images. This won’t exactly turn a Roku into a , but it’s a start.

The Roku Backdrops feature in action.The Roku Backdrops feature in action.

Roku

Roku TVs are also getting deep integration with IMDB in a forthcoming OS update. This will provide data sourced from the site as you scroll through potential shows and movies to watch. Finally, the mobile app is receiving a comprehensive upgrade, complete with a streamlined design, better search and new content categories.

The Pro Series line is available now from Best Buy, Amazon and Walmart. Prices start at $900 for the 55-inch model and rise up to $1,700 for the chunky 75-inch version. There’s also a wall-mount kit available for $100.

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Top yacht retailer MarineMax says cyberattack led to major online data breach

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MarineMax has confirmed suffering a cyberattack, thought to be ransomware, in which threat actors stole sensitive customer information.

In an 8-K form, filed with the Securities and Exchange Commission (SEC) on April 1, the company, one of the leading yacht sellers worldwide, said a third party “gained unauthorized access to portions of our information environment.”

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XGIMI Horizon Ultra review: LED and laser in perfect 4K Dolby Vision harmony

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XGIMI Horizon Ultra 4K review: Two-minute review

The XGIMI Horizon Ultra proves that projector technology is now so good that you really don’t need to spend the earth in order to get a fantastic viewing experience. While the 4K long-throw projector might be pretty pricey, in projector terms it’s a steal at $1,699 / £1,749 / AU$3,499. 

Despite the lack of native Netflix support that plagues all smart projectors, the XGIMI Horizon Ultra is a fantastic projector that punches well above its weight in terms of picture quality. It has a plethora of ports, onboard Dolby audio and image adaptation technology that makes it a breeze to use. 4K images are incredibly sharp and crisp, and the colors are vibrant and accurate. The blacks are deep and HDR performance brilliant, with great brightness even in well-lit conditions. 

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Bisnis Industri

Modern floor lamp gives you 16 million color LED options for $60

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This smart LED floor lamp comes with 68 dazzling light modes for only $59.99.
Light up your home in 16 million colors with this smart LED floor lamp, now $60.
Photo: Cult of Mac Deals

You don’t need to completely revamp your home to make it feel new and cool again. Just a dash of color can completely change the mood of any space, and that’s easy (and affordable) with this modern LED floor lamp that can be controlled via an app.

Meet the 55-inch RGB LED Remote Floor Lamp, a practical piece of home decor that can help you create the perfect ambiance with its dazzling range of smart lighting features. Right now, it’s only $59.99 (regularly $99) when you shop at Cult of Mac Deals.

Smart, sleek lighting that can amplify any space

Proper lighting is the unsung hero of any computer setup and makes a gigantic difference when it comes to the look and feel of any room. A modern floor lamp like this one can transform a space instantly.

This razor-thin home lighting option boasts powerful LEDs that are highly customizable. Whether you want to make your bedroom a more mellow, relaxing space or transform your living area into a vibrant setting for your next gathering, you can choose from 16 million color options and 68 light modes to personalize your lighting and curate the right aesthetic.

Sync your lighting to your music with this modern floor lamp

But that’s not the only impressive part. Thanks to a built-in microphone, this modern floor lamp can sync with your music to bring your lighting to life. You can control the lamp with the supplied remote or through the companion app (iPhone or Android).

Each option gives you granular control. You can select the perfect hue via a color wheel on your phone, and choose your ideal brightness using the digital dimmer switch that runs from 1% to 100%. The lamp even offers a timer setting, meaning there’s no need to turn the lamp off manually when you go to bed. Plus, you can schedule specific lighting for certain times of the day.

These features come packed into a slim aluminum-and-acrylic design that takes up little space. Its minimalist aesthetic looks good in bedrooms, living areas, gaming dens and most other spaces.

Save on an LED floor lamp with loads of color options

Grab this 55-inch LED floor lamp for just $59.99 for a limited time. That’s a 40% discount off the usual price of $99.99. And you can save even more if you buy two or three lamps in a bundle.

Buy from: Cult of Mac Deals

Prices subject to change. All sales handled by StackSocial, our partner who runs Cult of Mac Deals. For customer support, please email StackSocial directly.



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Smart light Notti is an LED table lamp with iPhone notifications

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Control this smart light with your phone, on sale for $24.99.
Save $15 on this smart light that pairs with your iPhone.
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If you’re looking for a stylish new LED table lamp that can set any mood, this one delivers — and it gives you notifications right from your iPhone. The Notti smart light hooks up to your smartphone through Bluetooth to give you a heads-up with a pop of color for calls, texts, Facebook updates and more.

For a limited time, you can get the Notti smart light on sale for just $24.99.

Notti smart light gives you iPhone notifications with a colorful twist

LED lamps (like this modern floor lamp) are all the rage these days. They’re both useful and fun, because they can turn your home or office lighting into something spectacular.

The Notti table lamp boasts an elegant white design that blends in with any room’s aesthetic even when it’s turned off. It offers 16 million colors to play with, lighting up your space however you want. With this LED light, you can set the mood for a quiet evening or get the vibes just right for a party. You can even sync this smart light to your music, letting it groove to the beat with you.

Plus, it lights up for your iPhone notifications

It also allows you to turn your iPhone’s (sometimes) annoying rings and buzzes into something more fun and visually appealing. Plus, it comes with an alarm function to make waking up a bit more bearable.

The Notti’s battery life stretches more than 720 hours in notification mode and more than five hours when used for continuous light. Power up with a micro USB, and pair with your device via Bluetooth 4.0 BLE up to 15 meters away. You can connect iPhone models starting from the iPhone 5 and later, iOS versions from 8 onward. It works with Android devices running 4.3 or above.

Save on an LED table lamp that offers 16 million colors

Level up your decor with the Notti smart light, on sale for just $24.99 for a limited time (regularly $39.99).

Buy from: Cult of Mac Deals

Prices subject to change. All sales handled by StackSocial, our partner who runs Cult of Mac Deals. For customer support, please email StackSocial directly.




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