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Featured

Can the iPad Mini survive?

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The answer to my titular question is a tentative ‘I doubt it’. And that’s a pity, as I’ve long been a fan of the iPad mini. 

Apple last updated its smallest fondle slate back in September 2021, which saw a specs boost and the removal of the sort-of iconic iPad Home button in favor of narrower bezels and Touch ID integrated into the power button, much like the iPad Air. I’m currently using the sixth-generation iPad mini, which replaced my decent if a tad long-in-the-tooth iPad mini 5, and I’ve got no real complaints about the latest mini other than a 90Hz or 120Hz display would be nice. 

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Politics

Children with ‘lazy eye’ are at increased risk of serious disease in adulthood

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Adults who had amblyopia (‘lazy eye’) in childhood are more likely to experience hypertension, obesity, and metabolic syndrome in adulthood, as well as an increased risk of heart attack, finds a new study led by UCL researchers.

In publishing the study in eClinicalMedicine, the authors stress that while they have identified a correlation, their research does not show a causal relationship between amblyopia and ill health in adulthood.

The researchers analysed data from more than 126,000 participants aged 40 to 69 years old from the UK Biobank cohort, who had undergone ocular examination.

Participants had been asked during recruitment whether they were treated for amblyopia in childhood and whether they still had the condition in adulthood. They were also asked if they had a medical diagnosis of diabetes, high blood pressure, or cardio/cerebrovascular disease (ie. angina, heart attack, stroke).

Meanwhile, their BMI (body mass index), blood glucose, and cholesterol levels were also measured and mortality was tracked.

The researchers confirmed that from 3,238 participants who reported having a ‘lazy eye’ as a child, 82.2% had persistent reduced vision in one eye as an adult.

The findings showed that participants with amblyopia as a child had 29% higher odds of developing diabetes, 25% higher odds of having hypertension and 16% higher odds of having obesity. They were also at increased risk of heart attack — even when other risk factors for these conditions (e.g. other disease, ethnicity and social class) were taken into account.

This increased risk of health problems was found not only among those whose vision problems persisted, but also to some extent in participants who had had amblyopia as a child and 20/20 vision as an adult, although the correlation was not as strong.

Corresponding author, Professor Jugnoo Rahi (UCL Great Ormond Street Institute for Child Health, UCL Institute of Ophthalmology and Great Ormond Street Hospital), said: “Amblyopia is an eye condition affecting up to four in 100 children. In the UK, all children are supposed to have vision screening before the age of five, to ensure a prompt diagnosis and relevant ophthalmic treatment.

“It is rare to have a ‘marker’ in childhood that is associated with increased risk of serious disease in adult life, and also one that is measured and known for every child — because of population screening.

“The large numbers of affected children and their families, may want to think of our findings as an extra incentive for trying to achieve healthy lifestyles from childhood.”

Amblyopia is when the vision in one eye does not develop properly and can be triggered by a squint or being long-sighted.

It is a neurodevelopmental condition that develops when there’s a breakdown in how the brain and the eye work together and the brain can’t process properly the visual signal from the affected eye. As it usually causes reduced vision in one eye only, many children don’t notice anything wrong with their sight and are only diagnosed through the vision test done at four to five years of age.

A recent report from the Academy of Medical Sciences* involving some researchers from the UCL Great Ormond Street Institute for Child Health, called on policymakers to address the declining physical and mental health of children under five in the UK and prioritise child health.

The team hope that their new research will help reinforce this message and highlight how child health lays the foundations for adult health.

First author, Dr Siegfried Wagner (UCL Institute of Ophthalmology and Moorfields Eye Hospital), said: “Vision and the eyes are sentinels for overall health — whether heart disease or metabolic disfunction, they are intimately linked with other organ systems. This is one of the reasons why we screen for good vision in both eyes.

“We emphasise that our research does not show a causal relationship between amblyopia and ill health in adulthood. Our research means that the ‘average’ adult who had amblyopia as a child is more likely to develop these disorders than the ‘average’ adult who did not have amblyopia. The findings don’t mean that every child with amblyopia will inevitably develop cardiometabolic disorders in adult life.”

The research was carried out in collaboration with the University of the Aegean, University of Leicester, King’s College London, the National Institute for Health and Care Research (NIHR) Biomedical Research Centre (BRC) at Moorfields Eye Hospital and UCL Institute of Ophthalmology and the NIHR BRC at UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital.

The work was funded by the Medical Research Council, the NIHR and the Ulverscroft Foundation.

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Life Style

‘There is no cookie cutter female scientist’

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Julie Gould 00:0

Hello, and welcome to Working Scientist, a Nature Careers podcast. I’m Julie Gould. We’re starting off a new series of episodes where I’ll be sharing stories from female scientists in Latin America.

Working as a scientist in Latin America comes with its challenges, whatever gender you identify with. There’s a severe lack of funding for science. There are difficulties in getting reagents. And there’s a lot of political instability in many countries in the region.

And yet for women, there are many other difficulties. And sometimes the women that I’ve spoken to feel that they are invisible.

Yet in the face of the challenges that they have, female scientists in the region are making it work. They are forming alliances nationally and internationally to support each other so that they can each follow the career path that they’re on.

In this series of episodes, I’m going to share some of the ways in which female scientists in Latin America are finding things difficult. But also I want to look at how they are facing these challenges head on.

To start the series, I’m sharing part of a conversation that I had with Monica Stein.

Monica Stein: 01:29

So my name is Monica Stein. I’m the Vice Rector for research partnership and collaboration at Universidad del Valle de Guatemala, based in Guatemala City.

Julie Gould 01:40

Monica works closely with people all around the world to try and strengthen science and technology ecosystems in Guatemala and the region.

I reached out to her after I listened to a roundtable discussion hosted by Nature in 2022, about female scientists in Latin America. Monica spoke during this roundtable about the different frameworks that exist for supporting science and scientific research.

I wanted to find out more about what frameworks exist in Guatemala, for women, and how she believes that they can and need to change to offer further support for the female scientists that work there.

The interview starts with Monica giving us an overview of how the frameworks right now are not supporting women in science, and are creating an unequal playing field.

Monica Stein: 02:23

Frameworks are complex. If you want to develop both vocations, careers and success in science and technology.

So in order to have a vibrant and productive scientific community that encompasses different ethnicities and different genders, you need to be able to have funding for science. So that’s the people the one people always think about.

But you need to also have the administrative framework to assign that funding. You need to have talent that can access that funding and infrastructure to be able to work within.

And that all sounds nice. But let’s start with the talent part. If you want to do science, you have to start inspiring people and demonstrating to people that that’s achievable from a very young age.

In general, many Latin American countries have trouble inspiring vocations in science and technology, because math is an issue.

And that is very disparate between men and women in Latin America and in the entire world. So there’s cultural norms and perceptions. That’s one first issue, where women shouldn’t be scientists or women don’t have the talent to be scientists.

And so in whatever framework that you want to achieve this high end goal of women doing scientific research and publishing, etc, you have to start years before inspiring women and role modeling, through women that are already in science, that it’s achievable, that it’s fun, and that all women can be scientists, engineers, or what have you, if they want to.

So that that is a whole piece of work that has to do that has to happen during school. And during college.

Once you have those, those vocations, you’ve inspired enough people, you have to make them aware of the opportunity. So there’s an access issue.

So we already did cultural norms and perceptions. And now we’re talking about access.

Do women have equal access to education as men do in some countries? They do. In some countries, they don’t. What does access mean? Is it only that the university accepts men or women and they don’t discriminate?

No, it doesn’t mean that. It means you know, are there other roles in terms of caretaking or work or what have you that are different between men and women. Are their preferences for a family to invest more in the education of a son than a daughter?

Or do you, as a student have to pay for your own education? And how easy is it for a man versus a woman to get a job, and what’s the pay gap?

Most of our students, for example, work to pay for their studies. So if there’s a pay gap, which there is in Guatemala, between men and women, and if it’s easier for men to have a job over women, then it’s easier for men to study than women. So that there’s that access issue.

And then. let’s say that you finally inspire people, you’ve got access, they’re graduating. Now you really get into this systems, regulations, whether they’re legal, or, or other types of regulations that promote the success of women in science.

And what you see in the United States, and you’re starting to see in Latin America, and the statistics support that, is that we’re getting more women graduating from university than men. Also, in Latin America, as an average.

It’ll vary from country to country, but then less women in graduate school. In Latin America. In the United States, I think women in biological sciences are very high up in graduate school, but then there are very low and tenured professor positions.

And what happens is you get married and you start having kids. And there are no support systems in Latin America for child caring, no robust support systems, certainly not in Guatemala, and much less in scientific systems where there’s a tenure system, and you’re expected to maintain certain productivity in order to gain certain rewards.

And that reward could be a position, or it could be just maintaining your job, or it could be going up the ladder.

So we had, for example, interesting conversations with Argentinian scientists, where they have in some universities a tenure system. And they don’t stop the clock, when a woman has a child.

So the moment that you have a child and your responsibilities are split, which they shouldn’t be split. You should be able to care for your child for a little bit. But your responsibility, so split, men will have an advantage because they’re producing science more consistently, and the clock doesn’t stop for women.

So things like that are things that, if you have a framework of regulations, and and support systems at the scientific, you know, production level productivity level, when you’re already a working scientist, would help women achieve more success in science.

And then I think, finally, there’s data and evidence that sometimes women’s contributions or production gets ignored in, in collaborative research, or whether having a woman as a primary author gives you advantages or disadvantages.

There was a survey in Central America regarding how many women scientists had positions and were publishing.

And the big surprise was that in Guatemala it was pretty equal between men and women. But it wasn’t so in El Salvador, Honduras and other Central American countries.

So for some reason, in Guatemala, at the level of scientific production, meaning how many papers you’re publishing and and whether women have jobs as scientists, we’re doing pretty well, which, which was a surprise.

But I know that in other countries, there are more positions filled by men and more papers published by men.

Julie Gould 08:48

Thank you so much for that overview of the current situation. But what do you envision for the future?

What do you think these future supporting frameworks should look like? And how would you put them in place?

Monica Stein: 09:00

Well,I think that it’s all part of an educational journey. So if science and technology organizations want to create that framework, they have to collaborate with other instances, like in Guatemala ministries of education, or in the United States, education secretaries, etc.

So what do I dream of? I dream of a system that collaborates with educational institutions to inspire and promote scientific vocations. Whether it’s for women, for low income students, men or women for different ethnic groups.

I think that’s very important because we are not going to be able to solve these really complex social problems that we have in Central America and other Latin American countries, if you don’t have a diversity of perspectives.

I firmly believe that science can inform complex social problems because evidence-based decision making is the best kind of decision making. So we have to include people, I dream of a system that will facilitate access to education. =

And it’s not only whether I don’t discriminate in my admissions, it’s whether I am providing the pathways. For example, here in Guatemala, in the highlands, where there’s a larger indigenous population, our university has a high school, and you can get your scholarships from the high school level, so that you’re prepared and to go to university, and that transition is less difficult.

But that there’s geographical aspects to that, too. And parents naturally don’t want to send their kids far away for high school. They’re okay with university, but they’re not okay for high school.

So can we use technologies to facilitate access? How can we raise the level of science education in high school so that people don’t have to leave their homes to get an education. So how to facilitate access.

And then we can get into, you know, legal norms or regulations within our system of science and technology that will permit different groups to have more equitable standing, and a fair evaluation and assessment so that you can keep going up, whether it’s in your birth, your workplace, or in a science and technology system.

And then comes funding. Like, honestly, what we found is if we have talent, the funding will come. And it’s really nurturing that talent that were really, really bad at.

Julie Gould 11:33

That was really interesting, because I’ve almost heard the exact opposite, that you can’t attract the talent if you haven’t got the funding. So could you explain your thoughts a little bit more, please?

Monica Stein: 11:43

Okay, so yes, you can’t get the talent if you don’t have the funding, because you need the funding to make these, you know, broad level changes.

But what we have found at UVG, is that it’s not that much money that you need to make the changes. It’s, it’s willpower. And it’s time. And yes time is valuable.

So for example, taking the time to measure how many women are in your programs. We have this really successful women in engineering summer course, that started as an experience for 25 young women from Guatemala City to come and learn about engineering.

And after the pandemic became this big 600-woman course all over the country, where we send them their boxes of material that is made in our MakerSpace. And we do it virtual.

And sometimes we invite professors from MIT or other places to give them talks. And that’s $15,000.

Now, that may sound like a lot of money to some people, but in the grand scheme of an institution, it’s not that much money to inspire 600 women, or more every year.

We have a lot of help from donors. So I think one of the secrets of success of this university is partnering.

So being isolated is not a way to build a system. If you’re going to build a system and an ecosystem, you have to collaborate, you have to be open. And so we have donors that help along the way.

So I think that there’s a lot of little steps you can take to inspire people, and make them realize that they have a vocation, and get interested in science that are not very expensive.

Then there’s the issue of access. Yes, of course, you need scholarships for access. And I think it is a government’s responsibility to be able to provide access to education.

But as a university, you can advocate for access. You can also participate in how you structure that axis. You can connect donors.

And when I say I don’t think money is the problem is that really, when you get a lot of people together, and they each add a little bit, then the money comes.

If you have a vision that you can pitch, the money comes. For example, we have this amazing new program with MIT, the Massachusetts Institute of Technology. And it’s a $15mi program funded by USAID to strengthen the university science technology ecosystem and entrepreneurship and innovation as well.

And how do you get that? By having a vision and by having these little success stories that show that there’s things you can do that are replicable, and that have an impact and are measurable, and then the funding comes? That’s my view on it.

Julie Gould 14:34

I love your positivity on this. But I know that not all institutions in Latin America are in a position where getting funding is as simple, especially those that are in countries where the political climate isn’t favoring science and education, or at least not favouring it as much as you’d hope.

So what advice would you have for them to build an ecosystem and to find funding and to build the infrastructure to support the scientists that are doing there.

Monica Stein: 15:01

I would like to clarify that the Guatemalan government is not giving the support that is necessary and that when you compare investment in science and technology, we are at point zero 3% of GDP.

So we’re one of the lowest in Latin America. I think that different Latin American countries have different regulatory frameworks. And that’s a big challenge.

For example, a challenge here that we have turned into an opportunity is that Guatemala is the only country in all of Latin America that does not have a higher education, supervision body.

So a quality supervision body. That’s horrible. All Latin American countries, and most countries in the world, some sort have some sort of state supervision entity that wants to improve quality.

We’ve turned that into an opportunity, because we’re able to be more innovative sometimes then other of our colleagues or other institutions, in some, especially South American countries, where it takes years to change the curriculum.

And it takes years to get a new program approved. So we’ve been able to innovate a lot easier. So I think those are the little challenges that get turned into opportunities.

Another thing that Guatemala has, because there is no government support for education (and higher education, for sure), but also high school education. Like there is in other countries.

We’ve had to look outside. So we’ve gotten quite good at writing grants for international donors. And there are a lot of colleagues that are still literally battling with their national funding system.

And if you don’t diversify your funding sources, you have less capability of saying yes or no to different things are charting your own path. And I think it’s hard to diversify your funding sources. But necessity is the mother of invention.

We’ve started. So at UVA we sell scientific cervices. And since 2010, to now 50%, of the operation of our research institute comes from sale of scientific services. Because we can survive on the overhead of grants.

We’ve been really, really bootstrapping this. And maybe that’s why I’m so optimistic. I think that challenges should be turned into opportunities. And I am very cognizant that there are a lot of hurdles in other countries where the regulatory frameworks are really, really rigid.

And Guatemala, because it is such a poor country, has more access to international funding than other countries that are more well off.

So my advice would be try to turn every challenge into an opportunity. Look outside the country, look at what that challenge can give you flexibility in another way. And, partner. We learned a lot of these things by talking to other people talking to people in developed countries, and in non developed countries partnering, this is the way to go. ,

Julie Gould 18:05

Okay, so with that in mind, what have you learned and incorporated from other countries, other institutions that you are using do work towards and build a framework that supports female scientists in your institution and in Guatemala?

Monica Stein: 18:19

Absolutely. I think one of the biggest things for us was learning from the development space, which is different from the scientific space. What a gender analysis do does, and how to do it, and how you change projects to include a gender perspective.

So they have dimensions of gender challenges, and ways of addressing them. And when we started incorporating those dimensions of gender analysis, and then actions that mitigate the effects of that disparity into what we did, we started getting results.

So we’ve learned from the development space in terms of how to streamline gender perspectives into what we do here at UBG.

In terms of regulation, I wish I could have a lot of success stories. It’s really hard to say, to change regulation. And we don’t have a merit system. In Guatemala, our national Secretariat of science and technology doesn’t even have a merit system, like in Mexico or Columbia.

So one of the things we’ve been doing as a university is trying to propose a merit system, so that scientists that have gone through more training or more projects can access bigger pots of funding, etc.

And I think that if you learn from other systems, like we’ve been learning from Colombia, from Argentina, etc. you can try to construct a better one.

You can, it’s not changing one but building one from scratch. That has been really hard. It’s been over 10 years in proposals and going back and forth and we still don’t have a clear system for measuring science output in different institutions from our Secretariat of science and technology.

We’ve partnered in some really cool initiatives. So we’ve partnered with European Union Initiatives for gender in Latin America, in educational institutions, also, with German cooperation, specifically for gender for science for STEM, Science and Technology, where we’ve been able to talk not only with the European see the European models, but talk to the different local models.

That’s been incredibly enriching. And it also creates a network of women that you can talk to and that are having the same challenges. And what most of them have done is, of course, raise awareness. So raising awareness is always the first step.

But gathering the data so that your awareness-raising is more impactful, and then piloting piloting different programs where they’re changing little parts.

So they’re changing how something is awarded, or they’re changing how they’re selecting participants, or they’re changing the topics that are approached in certain conferences, etc.

So all of that has been lessons learned. And I think it’s all very fluid and very dynamic. So we have WhatsApp groups, we have exchanges, sometimes we’ll have with the German cooperation, for example, a roundtable to keep that conversation going.

And I think that those linkages are what makes this fluid conversation advance.

Julie Gould 21:37

So I’m getting as a very prominent message under everything that you’ve said to me so far today, that networking is invaluable, both for individual women’s careers, but also for the job that you’re doing.

And that networking is one of the key tools that female scientists can have in a very large toolbox to help support their careers. Did I get that right?

Monica Stein: 21:59

Absolutely. And you said it really well. It’s not only your professional life, also your personal life, it’s not easy being a human. And it’s not easy being a woman. And I think that being able to connect with other people that are facing similar challenges, and they’re solving them in different ways, is incredibly valuable.

And we were asked recently, precisely by this German cooperation agency, who are setting up some other activities with women, female scientists, whether they should make them sectoral because of the language, you know, just Latin America, just Africa, just Asia.

And unanimously, all of us women from Africa, Asia, and Latin American said, No, we have to make them general, because we have learned so much about the different challenges different women in different cultures, face.

And in your personal life. of course, you need you need a village, you need a network of women, that it can be there for you in different aspects, even if it’s just listening, or if it’s helping out, giving out ideas. And you need to be there for them.

So we need to inspire other women, we need to mentor other women, we need to be available for conversations, we need to tell them it’s okay to say no to a project, because you’re pregnant, just giving birth, or your child is young, which is something that is so common here in Guatemala.

Women coming to me saying, If I don’t take this project, my career is dead, but I have a three month old. And being able to tell them “Don’t take the project.”

This happened to me, I didn’t take the project. And it didn’t affect you know, the the overall scheme of things and having them hear that from somebody that’s been there, gives them the courage to say okay, I’m going to set limits.

And I’m going to prioritize myself, as well as my career with the limits that I decided okay for me, because I know that in the end, I will be able to find another step or another path.

Julie Gould 24:01

So what are the other tools that female scientists should have, whether they’re in Latin America or anywhere else in the world?

Monica Stein: 24:07

Mentoiring is a big one. And it’s not exactly networking. It’s not exactly role models, but it’s a little bit of both put together. I think mentoring is very important. If you mentor a woman, or if you mentor two women or three women, you have a big multiplying effect. I think that working on axis is also very important, we already mentioned that.

And working on regulation. So you have to be able to propose and the changes you want to achieve are right, the grants that include the stipends, the scholarships, etc, that you are going to be then be able to give.

But I think motivation is the driver. I think inspiring people from when they’re very young is the biggest driver. And we can all do that.

And can I add something? We focus a lot on women But we forget the role men have in all of this. And if you role model to men and women, women in positions of power, men start recognizing that it’s normal to have women in positions of power.

If you sit women in decision making tables, then other men will start respecting female opinions more and more.

So I think there’s also work to be done in role modeling for men as well, women’s, women scientists, and also to intentionally include women in decision making roles and decision making bodies, to, to showcase that women do belong in the boardroom, in the CEO seat in, you know, the secretariat of science and technology.

Julie Gould 25:51

Okay, my final question for you, Monica, then is do you have any other advice for young female scientists?

Monica Stein: 26:00

I think the only thing left to say is that there’s no cookie cutter, woman scientist.

There’s no one single way to approach science and do science. That was a big one. For me. I thought there was a single path.

You got your PhD, you got your postdoc, you got your tenure, otherwise, you’re a failure. It’s okay to be a woman science in teaching, a woman scientist in teaching it’s okay to be a woman scientist in industry.

It’s okay to be a woman scientist in management. Because as long as you’re having impact, and that impact is fulfilling you and also contributing to building a better ecosystem, you are a woman in science.

And I think that’s very important that women internalize that there are many ways to be successful or what they want to be.

Julie Gould 26:49

Thank you to Monika Stein from UVG in Guatemala for speaking to us for this episode. There were many topics that Monica covered from funding to childcare to supporting the development and inspiration of female scientists at school level, and we will hear from women who are working on these things in the upcoming episodes.

Thanks for listening. I’m Julie Gould.

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Entertainment

You can get a PS5 with Spider-Man 2 for $400 right now

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Now might be a good time to snap up a PlayStation 5 if you’ve been on the fence and are particularly interested in playing Marvel’s Spider-Man 2. A bundle of the console and the game is currently $50 off. The savings apply to both versions of the console, so you can snag an all-digital version of the PS5 with Spider-Man 2 . If you’d prefer to have a standard edition of the console with a disc drive to perhaps watch Blu-ray movies on, the bundle .

Sony Interactive Entertainment

You can snag a bundle of a PS5 and one of its best exclusive games for $50 off at the minute.

$400 at GameStop

If you’re a newcomer to the PlayStation ecosystem, Spider-Man 2 is an excellent way to get your collection of PS5 games started. It’s and we felt it was than the first game in the series. If you’d prefer to play Marvel’s Spider-Man and Marvel’s Spider-Man: Miles Morales before diving into the latest entry (both are great games too), you can check them out through the PlayStation Plus subscription service on the Extra and Premium tiers. However, some folks may now be joining the PlayStation club after already playing those two games on PC — I wouldn’t want to wait too long for Spider-Man 2 to arrive on PC after first playing the previous entries there either.

When it comes to a modern gaming system, you can’t go far wrong with the PS5. It’s our pick for the , alongside the Xbox Series X/S.

It has a at this point and it can run pretty much any PS4 game too. Along with strong performance and excellent visuals, the PS5 has one killer feature that helps it stand out from the Xbox Series X/S: the DualSense controller. The haptic feedback and adaptive triggers (i.e. varying tension levels in the L2 and R2 buttons as you pull the string on a virtual bow or drag an object) help create a feeling of immersion Xbox consoles can’t quite match yet.

Follow @EngadgetDeals on Twitter and subscribe to the Engadget Deals newsletter for the latest tech deals and buying advice.



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Featured

TikTok could be banned – What a US ban would mean and how would it work

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It’s been almost exactly a year since the last significant threat of a TikTok ban in the US. This time, a bill to ban the popular social media app on US shores passed by a unanimous vote in the House of Representatives committee. Considering the bipartisan support, the bill may glide through the House, to the Senate and end up on President Joe Biden’s desk within weeks.

The prospect of a total US ban now seems very real. 

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Politics

Lack of focus doesn’t equal lack of intelligence — it’s proof of an intricate brain

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Imagine a busy restaurant: dishes clattering, music playing, people talking loudly over one another. It’s a wonder that anyone in that kind of environment can focus enough to have a conversation. A new study by researchers at Brown University’s Carney Institute for Brain Science provides some of the most detailed insights yet into the brain mechanisms that help people pay attention amid such distraction, as well as what’s happening when they can’t focus.

In an earlier psychology study, the researchers established that people can separately control how much they focus (by enhancing relevant information) and how much they filter (by tuning out distraction). The team’s new research, published in Nature Human Behaviour, unveils the process by which the brain coordinates these two critical functions.

Lead author and neuroscientist Harrison Ritz likened the process to how humans coordinate muscle activity to perform complex physical tasks.

“In the same way that we bring together more than 50 muscles to perform a physical task like using chopsticks, our study found that we can coordinate multiple different forms of attention in order to perform acts of mental dexterity,” said Ritz, who conducted the study while a Ph.D. student at Brown.

The findings provide insight into how people use their powers of attention as well as what makes attention fail, said co-author Amitai Shenhav, an associate professor in Brown’s Department of Cognitive, Linguistic and Psychological Sciences.

“These findings can help us to understand how we as humans are able to exhibit such tremendous cognitive flexibility — to pay attention to what we want, when we want to,” Shenhav said. “They can also help us better understand limitations on that flexibility, and how limitations might manifest in certain attention-related disorders such as ADHD.”

The focus-and-filter test

To conduct the study, Ritz administered a cognitive task to participants while measuring their brain activity in an fMRI machine. Participants saw a swirling mass of green and purple dots moving left and right, like a swarm of fireflies. The tasks, which varied in difficulty, involved distinguishing between the movement and colors of the dots. For example, participants in one exercise were instructed to select which color was in the majority for the rapidly moving dots when the ratio of purple to green was almost 50/50.

Ritz and Shenhav then analyzed participants’ brain activity in response to the tasks.

Ritz, who is now a postdoctoral fellow at the Princeton Neuroscience Institute, explained how the two brain regions work together during these types of tasks.

“You can think about the intraparietal sulcus as having two knobs on a radio dial: one that adjusts focusing and one that adjusts filtering,” Ritz said. “In our study, the anterior cingulate cortex tracks what’s going on with the dots. When the anterior cingulate cortex recognizes that, for instance, motion is making the task more difficult, it directs the intraparietal sulcus to adjust the filtering knob in order to reduce the sensitivity to motion.

“In the scenario where the purple and green dots are almost at 50/50, it might also direct the intraparietal sulcus to adjust the focusing knob in order to increase the sensitivity to color. Now the relevant brain regions are less sensitive to motion and more sensitive to the appropriate color, so the participant is better able to make the correct selection.”

Ritz’s description highlights the importance of mental coordination over mental capacity, revealing an often-expressed idea to be a misconception.

“When people talk about the limitations of the mind, they often put it in terms of, ‘humans just don’t have the mental capacity’ or ‘humans lack computing power,'” Ritz said. “These findings support a different perspective on why we’re not focused all the time. It’s not that our brains are too simple, but instead that our brains are really complicated, and it’s the coordination that’s hard.”

Ongoing research projects are building on these study findings. A partnership with physician-scientists at Brown University and Baylor College of Medicine is investigating focus-and-filter strategies in patients with treatment-resistant depression. Researchers in Shenhav’s lab are looking at the way motivation drives attention; one study co-led by Ritz and Brown Ph.D. student Xiamin Leng examines the impact of financial rewards and penalties on focus-and-filter strategies.

The study was funded by the National Institutes of Health (R01MH124849, S10OD02518), the National Science Foundation (2046111) and by a postdoctoral fellowship from the C.V. Starr Foundation.

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Life Style

Could AI-designed proteins be weaponized? Scientists lay out safety guidelines

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AlphaFold structure prediction for probable disease resistance protein At1g58602.

The artificial-intelligence tool AlphaFold can design proteins to perform specific functions.Credit: Google DeepMind/EMBL-EBI (CC-BY-4.0)

Could proteins designed by artificial intelligence (AI) ever be used as bioweapons? In the hope of heading off this possibility — as well as the prospect of burdensome government regulation — researchers today launched an initiative calling for the safe and ethical use of protein design.

“The potential benefits of protein design [AI] far exceed the dangers at this point,” says David Baker, a computational biophysicist at the University of Washington in Seattle, who is part of the voluntary initiative. Dozens of other scientists applying AI to biological design have signed the initiative’s list of commitments.

“It’s a good start. I’ll be signing it,” says Mark Dybul, a global health policy specialist at Georgetown University in Washington DC who led a 2023 report on AI and biosecurity for the think tank Helena in Los Angeles, California. But he also thinks that “we need government action and rules, and not just voluntary guidance”.

The initiative comes on the heels of reports from US Congress, think tanks and other organizations exploring the possibility that AI tools — ranging from protein-structure prediction networks such as AlphaFold to large language models such as the one that powers ChatGPT — could make it easier to develop biological weapons, including new toxins or highly transmissible viruses.

Designer-protein dangers

Researchers, including Baker and his colleagues, have been trying to design and make new proteins for decades. But their capacity to do so has exploded in recent years thanks to advances in AI. Endeavours that once took years or were impossible — such as designing a protein that binds to a specified molecule — can now be achieved in minutes. Most of the AI tools that scientists have developed to enable this are freely available.

To take stock of the potential for malevolent use of designer proteins, Baker’s Institute of Protein Design at the University of Washington hosted an AI safety summit in October 2023. “The question was: how, if in any way, should protein design be regulated and what, if any, are the dangers?” says Baker.

The initiative that he and dozens of other scientists in the United States, Europe and Asia are rolling out today calls on the biodesign community to police itself. This includes regularly reviewing the capabilities of AI tools and monitoring research practices. Baker would like to see his field establish an expert committee to review software before it is made widely available and to recommend ‘guardrails’ if necessary.

The initiative also calls for improved screening of DNA synthesis, a key step in translating AI-designed proteins into actual molecules. Currently, many companies providing this service are signed up to an industry group, the International Gene Synthesis Consortium (IGSC), that requires them to screen orders to identify harmful molecules such as toxins or pathogens.

“The best way of defending against AI-generated threats is to have AI models that can detect those threats,” says James Diggans, head of biosecurity at Twist Bioscience, a DNA-synthesis company in South San Francisco, California, and chair of the IGSC.

Risk assessment

Governments are also grappling with the biosecurity risks posed by AI. In October 2023, US President Joe Biden signed an executive order calling for an assessment of such risks and raising the possibility of requiring DNA-synthesis screening for federally funded research.

Baker hopes that government regulation isn’t in the field’s future — he says it could limit the development of drugs, vaccines and materials that AI-designed proteins might yield. Diggans adds that it’s unclear how protein-design tools could be regulated, because of the rapid pace of development. “It’s hard to imagine regulation that would be appropriate one week and still be appropriate the next.”

But David Relman, a microbiologist at Stanford University in California, says that scientist-led efforts are not sufficient to ensure the safe use of AI. “Natural scientists alone cannot represent the interests of the larger public.”

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Entertainment

ULTROS and the palette of surreal sci-fi

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Game design is a daring and dangerous endeavor for Niklas Åkerblad, who creates under the name El Huervo. When he describes the artistic process behind , a neon-speckled platformer set in a demonic cosmic uterus, he talks about pushing against the sharp edges of introspection and sanity, drawing from wells of creativity buried deep in his psyche. It sounds like he could’ve slipped and fallen down any of those wells at any second, never to be seen again.

“I had a pretty rigorous discipline when it came to creating the world of ULTROS,” Åkerblad told Engadget. “It involves deep meditation while working and maintaining 100 percent focus to be able to know when harmony is achieved when working with such a dense flow of shapes and colors. It is almost impossible to cerebrally analyze this process, but it is rather something you have to feel, thus any external disturbance can greatly impact the process. It is perhaps not something I recommend others do without proper experience in creating visual art.”

Niklas Åkerblad, AKA El Huervo

Niklas Åkerblad

At the same time, Åkerblad is extremely practical about the business of making games. He’s been in the independent scene for years, and he’s enjoyed incredible success as the collaborator who provided the cover art and other assets for Hotline Miami and its sequel. You know the vibe — grizzled but radiant, with the threat of violence in every other pixel. He also composed a handful of songs for those games, including “” and “,” and he went on to develop , a 3D adventure set in a digital city of hackers, artists and activists that implemented programming as a core mechanic. Else Heart.Break() came out in 2015 and was a finalist at the Independent Games Festival that year.

His latest project, ULTROS, is a 2D exploration of The Sarcophagus, a looping world in a black hole that cycles players through environments overrun by alien plant life and vicious demons. Every scene in ULTROS is packed with detail and brilliant color; the backgrounds are alive with monsters and organic machines. Streaks of black delineate the boundaries of walking paths, ceilings and platforms, contrasted against shifting rainbows of luminosity.

ULTROS

Hadoque

There’s a lot going on in ULTROS at any given moment, but the protagonist stands out with a glowing green helmet, vermilion cloak and an evolving arsenal of platforming gadgets. One lesson from else heartbreak() that Åkerblad fed into ULTROS was the idea that games can have way more fun with color palettes. ULTROS is purposefully packed with visual interest.

“I felt video games tend to not push the boundaries of colors so much beyond ‘green is good’ and ‘red is bad,’ and whatever metrics are used for loot tiers,” he said. “I feel that there is this misunderstanding in design that less is more, and my gut tells me it’s the opposite and I worked very hard on ULTROS to prove my theory. Undoubtedly there will be those who do not agree with me, but I feel it has more to do with taste and personal or physical preferences than academic truth — if there is such a thing.”

As a cyclical Metroidvania title, ULTROS is completely different from Åkerblad’s previous projects, but it’s also undeniably El Huervo. Actually, in this case, it’s Hadoque — around 2017, Åkerblad and game director Mårten Bruggemann started building the prototype that would become ULTROS, eventually bringing in composer Oscar “Ratvader” Rydelius and Fe designer Hugo Bille. Other artists joined over the years, and they ended up calling themselves Hadoque, a loose organization of creators who could float in and out as a project called to them.

ULTROS

Hadoque

“We wanted our group to be associated with its own thing, so we decided on Hadoque,” Åkerblad said. “It’s a cool name that looks a bit weird and it suits our vibe. Also, it allowed everyone to still have their own thing on the side and not be legally tied to anything if they wished to pursue other venues.”

El Huervo AB remains Åkerblad’s own corporate entity, useful for dealing with the bureaucratic aspects of making video games. Through El Huervo AB, Hadoque received backing in 2019 from the gaming fund , which has also supported titles like Sifu, Rollerdrome, We Are OFK, Sea of Stars, Spiritfarer and Tchia.

“El Huervo AB merely functions as a sort of bureaucratic condom, and Hadoque as a name to be used when a group of developers come together to make art as games,” Åkerblad said. “Sort of like a band name. People come and go, but the vision remains.”

ULTROS is a game about life, rebirth, aliens, monsters and peace, and it all plays out in a technicolor dreamscape of vicious creatures and gorgeous foliage. This is the palette of surreal sci-fi, to Åkerblad.

ULTROS

Hadoque

“The themes explored in ULTROS are of an existential and spiritual nature, and I find that surreal sci-fi is a good genre to explore these themes in, as it has a long tradition of doing so,” he said. “In this regard, Ursula K. Le Guin has been a huge inspiration. Hopefully, what we manage to evoke in players is a sense of introspection and comfort.”

Despite the amount of deep thought that he’s done about the nature of art, sci-fi and play, there’s no singular message that Åkerblad is trying to convey with ULTROS. Instead, he and the rest of the developers at Hadoque encourage players to identify their own journey as they cycle through The Sarcophagus. As Åkerblad put it:

“Please enjoy ULTROS any way you want and don’t try to look for a ‘true’ interpretation, but rather find your own meaning. This goes for any art, I think, in general. Interpretation is purely subjective and I want to keep telling stories that invoke and allow this subjectivity to exist.”

ULTROS is available now on PlayStation 4, PS5, Steam and the Epic Games Store, published by Kepler Interactive.

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Featured

iPhone 16 Pro leaked renders might give us our first look at rumored Capture Button

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CAD files for what is purported to be the iPhone 16 Pro have recently surfaced online, giving people an idea of what Apple’s upcoming flagship may look like.

According to tech news site 91mobiles, the smartphone will look similar to the iPhone 15 Pro with a few notable differences. First off, the 16 Pro is potentially slated to be slightly larger than the current model, measuring 149.6 x 71.4 x 8.4 mm. The website’s industry sources go on to say it’ll have a 6.1-inch display. There is a discrepancy with this as older leaks claim the mobile device will have a 6.3-inch screen. 91mobiles, however, leans more toward the larger display due to the newly listed dimensions and the fact that the renders show thinner bezels around the glass. 

Renders of the iPhone 16 Pro

(Image credit: 91mobiles/Apple)

The biggest revision found in the files is the inclusion of the rumored Capture Button which will be located below the power button on the right side. The Capture Button, if you’re not familiar with it, is supposed to help users take better photographs by making the process more comfortable. You won’t have to tap the screen to take it.

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Politics

Good news for coral reef restoration efforts: Study finds ‘full recovery’ of reef growth within four years

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While the majority of the world’s reefs are now under threat or even damaged potentially beyond repair, a new study reported in the journal Current Biology on March 8 offers some encouraging news: efforts to restore coral reefs not only increase coral cover, but they can also bring back important ecosystem functions, and surprisingly fast.

“We found that restored coral reefs can grow at the same speed as healthy coral reefs just four years after coral transplantation,” says Ines Lange of University of Exeter, UK. “This means that they provide lots of habitat for marine life and efficiently protect the adjacent island from wave energy and erosion.”

“The speed of recovery that we saw was incredible,” she says. “We did not expect a full recovery of reef framework production after only four years.”

The work by Lange and her international colleagues represents the first reef carbonate budget trajectories at any coral restoration sites. The study was conducted at the Mars Coral Reef Restoration Programme in South Sulawesi, Indonesia, one of the largest restoration projects in the world. The project relies on transplanting corals and adding substrate to restore reefs badly damaged by blast fishing 30 or 40 years ago. Without human intervention, those reefs had shown no signs of recovering due to the presence of loose coral rubble that prevents young coral larvae from surviving.

The restoration effort has added a continuous network of sand-coated steel structures to consolidate the rubble and offer a structure for transplanting coral fragments. The question was whether and how quickly such restored sites would recover. To find out, the researchers measured the carbonate budgets of 12 sites that had been restored at different times, up to four years ago.

“Corals constantly add calcium carbonate to the reef framework while some fishes and sea urchins erode it away, so calculating the overall carbonate budget basically tells you if the reef as a whole is growing or shrinking,” Lange says. “Positive reef growth is important to keep up with sea-level rise, protect coastlines from storms and erosion, and provide habitat for reef animals.”

They wanted to know how long it takes to bring back healthy reef growth and its associated functions. Their data show that rapid growth of transplanted corals supports the recovery of coral cover and carbonate production. In fact, just four years in, the net carbonate budget had tripled such that it matched that at healthy control sites.

There were some important differences, however. Because branched corals had been transplanted preferentially over other corals, the makeup of the restored reef communities differs. The researchers say those differences “may affect habitat provision for some marine species and resilience to future heatwaves, as branching corals are more sensitive to bleaching.”

While longer-term study is necessary to see what happens over time and under stress, the findings show that active management actions can help to boost the resilience of reefs and bring back important ecosystem functions that are critical for marine life and local communities in relatively short periods of time, according to the researchers. They’re hopeful that, over time, restored reefs will naturally recruit a more diverse mix of coral species. However, they note that what will happen in any given location around the world will depend on many factors, including environmental conditions and restoration techniques.

“As is so often the case, there is no one-size-fits-all solution, but we hope that this positive example can be used as inspiration for other reef restoration projects around the world,” Lange says.

“These results give us the encouragement that if we can rapidly reduce emissions and stabilize the climate, we have effective tools to help regrow functioning coral reefs,” says Tim Lamont, a study co-author at the Lancaster Environment Centre, Lancaster University, UK.

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