Categories
Life Style

Indigenous Australian fire-stick farming began at least 11,000 years ago

[ad_1]

Aboriginal elder George Milpurrurr shows his children how to make a controlled fire to burn off dangerous dry grass.

Northern Australian elder George Milpurrurr shows the next generation how to do a cultural burn.Credit: Penny Tweedie/Alamy

Indigenous Australians have been using fire to shape the country’s northern ecosystems for at least 11,000 years, according to charcoal preserved in the sediment of a sinkhole. The study was published on 11 March in Nature Geoscience1.

The practice of cultural burning, also known as ‘fire-stick farming’, is integral to Indigenous Australian culture and history, and is understood to have profoundly altered landscapes across the country.

Fire-stick farming involves introducing frequent, low-intensity fires in small areas of the landscape in a patchy, ‘mosaic’ pattern, and is done early in the dry season. The practice is important culturally and environmentally; in particular, it reduces the amount of fuel available for burning and therefore decreases the intensity of wildfires that might spark late in the dry season because of lightning strikes or other triggers.

Archaeological evidence indicates that humans have continuously occupied the Australian continent for at least 65,000 years2, but little is known about when the practice of fire-stick farming began.

“You need a really long record that goes back before people were here so you can see what the natural world — the definitively unimpacted world, if you’d like — looks like and then you’ve got enough of a record to be able to see if anything changed,” says study co-author Michael Bird, a geologist at James Cook University in Cairns, Australia.

The researchers found that record in the sediment of Girraween Lagoon, a permanent water body formed in a collapsed sinkhole near Darwin in the Northern Territory. The lagoon is an important site for the traditional owners of the land, the Larrakia Nation, and was made famous by the crocodile attack scene in the 1986 film Crocodile Dundee.

Because the lagoon has remained full, its sediments offer a continuous record of deposition that has not been disturbed by drying out and cracking. Bird and his colleagues were able to extract a core from the bottom of the lagoon that provided a 150,000-year-long record of changes in the type and geochemistry of the deposited charcoal, and in the accumulation of pollen.

Change in the charcoal

The team notes that, around 11,000 years ago, the changes in the charcoal deposits point to alterations in the intensity of fires in the area.

Without human influence, fires are less frequent but have enough intensity to burn trees and leave behind charcoal, says Bird.

“A less-intense fire doesn’t get into the crown — it’s burning what’s on the ground,” he says. The grass, as well as twigs and fallen tree leaves, are more likely to become charcoal than the trees themselves, he adds.

Because tree-derived charcoal has higher concentrations of the isotope carbon-13 than does charcoal from grasses, the researchers analysed the composition and geochemistry of the burnt residue in the sample. The authors found a sustained change from low-frequency, high-intensity fires — the ‘natural’ fire regime — to more frequent but less intense ones, which they suggested was the result of Indigenous fire-stick farming.

The authors ruled out climate change as the cause of the shift by using the ratio of tree pollen to grass pollen as a type of climate history to show that vegetation changes did not explain the shift in the charcoal record.

However, Bird notes that European colonization has mostly brought an end to cultural burning practices, and has shifted fire intensity back towards a natural pattern. “Because we’ve had, 10,000 plus years of a particular fire regime, it’s the release from that fire regime that’s actually creating quite significant issues,” he says, suggesting that this shift has contributed to the return of more high-intensity wildfires.

Joe Fontaine, a fire ecologist at Murdoch University in Perth, Australia, says that the growing understanding of how cultural burning has shaped the Australian landscape, particularly in the northern regions, is crucial for contemporary fire-management practices, which to a large extent have excluded Indigenous people and their expertise.

“The barriers to doing cultural burning, in our arcane system of laws and bureaucracy,” are challenging to overcome, Fontaine says. There are also many more permanent structures in the landscape nowadays than there were before colonization, he says, so the challenge is to work out where and how cultural burning can be restored as a practice.

The continuing work that “puts cultural burning practices out there and establishes it as something that really existed, is crucial to the evolution of contemporary fire management,” he says.

[ad_2]

Source Article Link

Categories
Featured

World’s largest laptop vendor quietly releases robot with six legs — Lenovo Daystar Bot GS is IP-rated and reminds us of Boston Dynamics’ andro-dogs

[ad_1]

There can’t be many people who haven’t seen at least one video of Boston Dynamics’ robot dog Spot performing tricks like going up and down stairs, spinning, dancing, jumping, and carrying objects. The robot isn’t just for fun however. It can be used for a variety of work tasks, such as inspecting industrial sites and carrying out hazardous duties.

Spot isn’t the only industrial robot animal in town now, though. It has competition from an unexpected source – Lenovo.

[ad_2]

Source Article Link

Categories
Entertainment

Windows AI, Surface and more

[ad_1]

Microsoft is holding a digital event titled “Advancing the new era of work with Copilot” on March 21. Among the possible announcements are new Surface devices, potentially the first branded as AI PCs. It will already be the second Windows hardware event — and first mainline Surface Pro launch — without former chief product officer and longtime keynote presenter Panos Panay, who left for Amazon last year. Here’s everything we could see at the company’s first launch event of 2024.

The company describes the event as breaking down “the latest in scaling AI in your environment with Copilot, Windows, and Surface.” There are conflicting reports about exactly what we’ll see in late March.

Windows Central claims an OLED Surface Pro 10 and Surface Laptop 6 will headline the event, with their upgraded processors enabling “huge performance and efficiency gains” over their predecessors. However, a report from The Verge suggests this month’s event will only cover the business and commercial-focused versions of the devices — with much subtler upgrades than the consumer versions. The outlet claims the consumer variants with “a larger redesign” will follow later this spring.

The new devices will allegedly be powered by Intel Core Ultra or Snapdragon X Elite silicon with next-generation neural processing units (NPUs) for advanced AI tasks. The Intel variants are expected to launch in April, while the Arm-based Snapdragon ones will reportedly arrive several months later in June. If the reports are accurate, this would be the first time the Surface Laptop line has included an Arm-based version.

At least in the consumer models, the Surface Pro 10 is rumored to switch from LCD to an anti-reflective OLED screen. The device would be brighter than the Surface Pro 9’s screen and support HDR content. Meanwhile, the Surface Laptop 6 is rumored to include thinner display bezels (with rounded corners) and a haptic touchpad. Its updated port selection is said to include two USB-C and one USB-A on its left side.

The commercial / business models (which may be all we see at this month’s event) are rumored to include a built-in Common Access Card (CAC) reader and options with up to 64GB of RAM.

Image of a Windows keyboard with a dedicated Copilot AI key between the left arrow and Alt keys.

Microsoft

Whether at this month’s event or later, the new consumer-facing Surface Pro and Surface Laptop are expected to kick off Microsoft’s push for Windows 11-running AI PCs. They’ll reportedly be among the first to include an on-device version of Copilot. Other rumored AI features include real-time captioning and translation, upscaling and frame-rate smoothing for games, upgraded Windows Studio Effects and a feature called AI Explorer. Both devices will reportedly include a dedicated Copilot key.

AI Explorer is rumored to include a built-in timeline that’s searchable using natural language. Perhaps similar to the third-party Rewind AI app for macOS, the feature will allegedly log everything you do and see on your device, letting you sift through it with Copilot. It would let you ask the assistant things like, “Find me that thing about dinosaurs,” and see every moment in your PC’s history relating to them. (It could be a privacy nightmare if not handled properly, but expect Microsoft to offer security assurances like encryption and entirely on-device processing.)

The feature would also allegedly “understand context, help jumpstart projects or workflows, and even suggest tasks based on what’s currently on screen.” Other rumored features include the ability to tell Copilot to remove the backgrounds of onscreen images from third-party apps in the Photos app.

The AI features, which aren’t expected to be exclusive to the Surface devices, will reportedly arrive in this year’s annual feature update for Windows 11 (version 24H2), expected in the fall. Windows Central noted it isn’t clear whether Microsoft will discuss the features during the March event.

Engadget will have full coverage of Microsoft’s announcements on March 21 at noon ET.

[ad_2]

Source Article Link

Categories
Featured

3 great tools for editing group shots without making a royal mess of it

[ad_1]

Every year around Christmas, I hang an ornament on the tree featuring a photo of my family. There we are, all four of us, in one shot, Except something is wrong with the photo; while we’re all dressed in our winter best, we don’t quite hang together as a unit. In fact, it becomes quite clear that this is not a natural group shot and is something I cooked up in Photoshop because I needed a nice family photo for the ornament frame. No one is fooled when they look at it. 

Suffice to say, I feel for Princess of Wales Kate Middleton, the royal who, in an apparent effort to convey normalcy in what might not be entirely normal times, did a bit of family portrait photo editing wizardry that didn’t all go according to plan. There are numerous artifacts in her final image, shared widely over the weekend to celebrate UK Mother’s Day. So many that the Royal Family eventually pulled the photo and Middleton fessed up to doing some creative photo editing.

[ad_2]

Source Article Link

Categories
Featured

Continuous glucose monitors – health fad or the future of wellbeing?

[ad_1]

If you’re like me, you might never have heard of continuous glucose monitors (CGMs) until the last few months, if at all. However, if your online presence has found its way on to any health or wellness algorithms, you’ve almost certainly encountered at least one or two advertisements or endorsements for the technology.

That’s because these smart glucose sensors are being touted by manufacturers and lifestyle brands as the key to unlocking and improving metabolic health, despite having been invented primarily to provide diabetes patients with real-time glucose readings.

From Zoe and Lingo in the UK to Nutrisense and Levels in the US, new brands offering CGM-based lifestyle plans and health-tracking apps are everywhere. Even Apple and Samsung are racing to develop noninvasive glucose monitors to incorporate in some of the best smartwatches.

Graph showing the worldwide interest over time in CGMs

Graph showing the worldwide search interest for CGMs increasing over the last year (Source: Google) (Image credit: Future / Canva)

But what is metabolic health, and does the information generated by these devices provide any insight that can provably help non-diabetic users? These are the questions I sought to answer when I began my journey trialing CGMs this year. 

[ad_2]

Source Article Link

Categories
Life Style

‘Despair’ as Argentinian president begins dismantling science

[ad_1]

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here.

A ringed caecilian amphibian with newborn babies.

The worm-like caecilian Siphonops annulatus is the first amphibian described to produce ‘milk’ for offspring hatched outside its body.Credit: Carlos Jared

A species of amphibian is the first observed to nourish its young with a milk-like product, which it squirts from the cloaca, a combined rear opening for its reproductive and digestive systems. Siphonops annulatus is a blind, worm-like caecilian that lives underground. Lactation is considered a key characteristic of mammals, but a handful of other animals — including some birds, fish, insects and even spiders — produce nutrient-rich liquid for their offspring.

Nature | 3 min read

Reference: Science paper

At its annual meeting this week, China’s legislative body, the National People’s Congress, promised to increase government funding for science by 10% in 2024. It’s the largest boost to funding in five years. The increase comes as the Chinese economy struggles to meet growth targets and is locked in a race for technological supremacy with the United States. “To win this game, China has to invest in science and technology, especially in basic research,” says Marina Zhang, who studies innovation with a focus on China.

Nature | 3 min read

New president Javier Milei hasn’t outright shut down Argentina’s main national science agency, CONICET, as he pledged during his presidential campaign. But by keeping its budget unchanged — in a country where annual inflation stands at more than 250% — he is making it impossible for some laboratories to stay open, say critics. On Wednesday, 68 Nobel prizewinners in chemistry, economics, medicine and physics delivered a letter to Milei expressing their concerns. “We watch as the Argentinian system of science and technology approaches a dangerous precipice, and despair at the consequences that this situation could have for both the Argentine people and the world,” it says.

Nature | 5 min read

Stone tools found in western Ukraine date to roughly 1.4 million years ago, making them the oldest known artefacts in Europe made by ancient humans. The findings support the theory that our early relatives — probably of the versatile species Homo erectus first entered Europe from the east and spread west. The type of tools, and the location where they were found, hint that the first Europeans might have moved westwards along the valleys of the Danube River.

Nature | 5 min read

Reference: Nature paper

Close up view of a stone tool possibly from Layer VII at Korolevo I.

A stone tool from the archaeological site of Korolevo in western Ukraine.Credit: Roman Garba

Features & opinion

Researchers suggest that an imbalance in the intestinal microbiota might cause the gut to send signals to the brain that promote addiction behaviours. Even before a person’s first contact with alcohol or drugs, the imbalance could give rise to traits such as impulsivity, susceptibility to stress or anxiety, and sensation-seeking, creating a vulnerability that can lead to addiction. If that’s true, it could open the door to new treatments — but it’s not going to be simple to address disorders that are associated with many risk factors, including mental-health conditions and genetics. “People have asked me, ‘Can someone just eat yogurt and cure their addiction?’” says Drew Kiraly, a psychiatrist and physician. “It’s going to be much, much more complicated than that.”

Nature | 10 min read

This editorially independent article is part of Nature Outlook: The human microbiome, a supplement produced with financial support from Yakult.

There are four cognitive ‘traps’ that researchers should consider carefully before embedding AI tools in their research, say anthropologist Lisa Misseri and cognitive scientist Molly Crockett. They characterized these AI mindsets or ‘visions’ — ‘AI as Oracle’, ‘AI as Arbiter’, ‘AI as Quant’ and ‘AI as Surrogate’ — after reviewing 100 peer-reviewed papers, preprints, conference proceedings and books. In general, they warn researchers against imbuing AI systems with ‘superhuman’ abilities. “There’s a risk that we forget that there are certain questions we just can’t answer about human beings using AI tools,” says Crockett.

Nature | 44 min read

Read more: Why scientists trust AI too much — and what to do about it (Nature editorial | 6 min read)

Reference: Nature paper

Author Preston Grassmann weaves a world outside the “consensual hallucination” of cyberspace in the latest short story for Nature’s Futures series.

Nature | 6 min read

One behaviour that was thought to be unique to humans is the ability to learn something from your predecessors that you couldn’t figure out on your own. Now researchers have shown that bumblebees are also capable of this ‘standing on the shoulders of giants’ approach to learning. Bees taught how to complete a puzzle too difficult to solve on their own were able to share this knowledge with other bees, raising the possibility that this ability could be widespread among animals.

Nature Podcast | 36 min listen

Subscribe to the Nature Podcast on Apple Podcasts, Google Podcasts or Spotify, or use the RSS feed.

Quote of the day

Gender-equality researcher Susanne Täuber was dismissed from her job after blowing the whistle on bias. Her advice for others concerned about their workplace: trust your gut feeling. (Nature | 5 min read)

[ad_2]

Source Article Link

Categories
Featured

Motorola Moto G84 review | TechRadar

[ad_1]

Moto G84 two-minute review

Another day, another Moto G phone…

…and as usual, the Moto G84 is a surprisingly adept and reliable Android handset from one of the world’s most dedicated phone manufacturers, with Motorola continuing its forcible takeover of our round-up of the best cheap phones.

[ad_2]

Source Article Link

Categories
Life Style

Act now to prevent a ‘gold rush’ in outer space

[ad_1]

A SpaceX Falcon 9 rocket, carrying Intuitive Machines' lunar lander, lifts off from pad 39A at Kennedy Space Center in Cape Canaveral, Fla., early Thursday, Feb. 15, 2024.

SpaceX’s Falcon 9 has become a workhorse of the private satellite launch vehicle market.Credit: Associated Press/Alamy

Who Owns the Moon? In Defence of Humanity’s Common Interests in Space A. C. Grayling Oneworld Publications (2024)

The Moon seems to be back on everyone’s radar. NASA’s Artemis mission is expected to shuttle humans back to the lunar surface before the end of this decade. In the past year, Japan and India have successfully landed rovers there; Luna 25, a Russian effort almost half a century after the nation’s last, almost made it, but crash landed.

Several non-state actors are also stepping into the fray, with the space-exploration company Intuitive Machines, based in Houston, Texas, last month becoming the first private firm to complete a lunar touchdown — a feat that sent the company’s stock price soaring.

The fallout and consequences of this renewed clamour for the Moon is the subject of UK philosopher A. C. Grayling’s latest book. In Who owns the Moon?, Grayling explores one facet behind the interest in Earth’s pockmarked neighbour — a quest for resources.

India’s mission, for instance, was squarely aimed at exploring the Moon’s southern pole — a probable storehouse of frozen water, which could be converted into oxygen and rocket fuel. Grayling warns that human greed and national rivalries could set off a lunar ‘gold rush’ once the investment and engineering barriers to extracting extraterrestrial materials are surmounted. He calls for an urgent re-examination of the laws that govern space exploration.

Who owns the Moon — and perhaps more broadly, who owns outer space — is a complex, legally loaded question that has been asked since the space age commenced. Although a layperson might assume that there are no laws governing the exploration of the cosmos, international agreements, such as the 1967 Outer Space Treaty, do exist. Grayling’s contention is that such arrangements, negotiated under the auspices of the United Nations, are essentially cold war-era arms-control pacts, focusing primarily on prohibiting nuclear weapons in outer space and preventing any single country from claiming sovereignty over celestial bodies.

Trillion-dollar industry

Although this agreement has staved off major conflicts in space over the past nearly 60 years, the nature of space exploration has changed remarkably since then. For starters, private firms are now able to exert substantial influence on government-run space programmes. Private actors such as the US spacecraft manufacturer SpaceX, based in Hawthorne, California, already own a majority of the low Earth orbiting satellites. In 2022, the author states, the space industry was estimated to be worth US$350 billion and is projected to grow to more than one trillion dollars over the next two decades. Under these circumstances, the presence of intentionally vague and ambiguous terminology in existing international agreements — such as outer space being a “province of all mankind” held for the “common interest” — leaves room for misinterpretation.

If lunar bases end up becoming a reality, the existing legal framework will need an update. Without a bold new global consensus, Grayling predicts, a space ‘wild west’ is going to emerge.

In the absence of a concerted global dialogue, individual countries are pushing ahead with their own laws, such as the US Commercial Space Launch Competitiveness Act of 2015. Similar laws are being written or enacted in India, Japan, China and Russia.

Peace in space

Drawing on observations made by the UN’s Committee on the Peaceful Uses of Outer Space, Grayling writes that space law is getting more fragmented, thereby increasing the potential for conflict. An international regime that gives general guidance on most space-related matters — supplemented by a set of multilateral institutions that can support enforcement and adjudication — is imperative, he writes. Individual states can then focus on domestic licensing regimes for globally agreed activities. Whether one will come before the other is still an open question, but the signals point to domestic regimes moving faster than global governance.

The book’s main contribution is perhaps its chapters that document historical precedents, which offer lessons on how to set up mechanisms to facilitate global cooperation. According to some, the 1959 Antarctic Treaty is a shining example of a multi-party agreement that has kept narrow national interests at bay. However, it is important to point out that several signatories continue to maintain territorial claims. The law of the sea, a set of international agreements on the commercial exploitation of the oceans and the deep-sea bed, offers another template. However, these examples cited by Grayling do not necessarily transpose readily to outer space.

The spacecraft Odysseus moon lander before it began its moon landing on Thursday. Intuitive Machines reports that its IM-1 lander Odysseus has landed on the moon and is transmitting a faint signal. The Odysseus lander is the first privately built vehicle to make it to the moon.

Last month, Intuitive Machine’s Odysseus became the first module manufactured by a private firm to land on the Moon.Credit: Zuma Press/Alamy

For instance, the law of the sea is the product of hundreds of years of negotiation and power tussles between diverse competing actors — a body of collective knowledge that is unavailable to a young field such as space exploration. And Grayling doesn’t discuss the analogies with international environmental law, which would have been more relevant. For most of human history, the planet wasn’t conceived of as an environment, although today it is. A profound legal reimagination is taking place as a result. If outer space is set to become a part of our immediate environment, then there could be lessons to learn from the ongoing climate change-induced reconsideration of the nature of resource exploitation here on Earth.

Without an overarching governance structure, disputes in space can be hard to deal with. Currently, when a conflict arises between two space-faring nations, not only does the vagueness of international space law ensure that there is no clear process to engage in consultation, there is also no mechanism to pin accountability. This is clearly a choice exercised by the currently dominant players who can, as a result, interpret the phrase ‘freedom of outer space’ in any way they choose.

The 1972 Space Liability Convention — a treaty that is pressed into service in case of injury to persons or damage to property owing to space-related activities — has been officially invoked just once, when a Soviet satellite deposited radioactive debris in Canadian territory in 1978. The Soviets had to pay Can$3 million (at the time around US$2.5 million) to settle the dispute.

Soon, such conflicts might spill over, as our conception of ‘damages’ expands to potentially include activities that harm the common environment that lies beyond national boundaries. Grayling repeatedly invokes the late-nineteenth century’s Scramble for Africa as a cautionary tale of what might happen if humanity’s worst instincts are let loose. At the very least, Grayling writes, our successors in the second half of this century and beyond will not be able to say: “no one warned us; no one reminded us of what history shows could so easily go wrong when it is considerations of money and power that alone drive events”.

The next generation

It is precisely to enable such wider debate that I focus so much of my effort and outreach on building the capabilities of African youth in the domain of space governance. According to the World Economic Forum, more than 40% of the global youth population will be African by the end of this decade. They are an important stakeholder, and they are the custodians of our collective space future.

When I was a trainee lawyer working for the Nigerian space agency nearly 17 years ago, my area of specialization was the application of international environmental law to space debris. Today, space junk is a global and increasingly mainstream concern. This is why genuine international cooperation is essential. The best ideas can come from anywhere. Diversity should build trust.

Looking ahead, if I can indulge in some crystal-ball gazing, it seems likely that institutional and state governance mechanisms for managing the Moon — and outer space — will become a priority area in the coming years. Usually, such international arrangements tend to arise when there is a real risk of conflict. Despite the prevailing narrative about a second space race, there is currently little appetite for international dialogue on space-related matters that limits the freedom of the dominant actors. But this could change. What happens when the middle powers rise?

International space law is unique because the state is directly responsible and liable for all activities undertaken by its citizens, including those in the private sector. Given that some private space firms have more wealth and power than do many space-venturing nations, the scrutiny on these non-state actors will only increase.

Any future dispute-resolution mechanisms must balance inclusivity and justice, and acknowledge that space commercialization is a deep national security concern for many states. What happens in outer space should inextricably be linked to developmental debates on Earth. Otherwise, although space might nominally be for the ‘benefit of all’ — as per the Outer Space Treaty — a select few nations or companies could indulge in rapacious over-exploitation. So, we need to seriously ponder who will benefit and what will comprise the common interest.

Although Grayling does not address all these concerns in depth, Who Owns the Moon? is still an important introductory text on the issues and challenges that humanity will have to confront as it ventures to the Moon and beyond.

[ad_2]

Source Article Link

Categories
Featured

I can’t believe I’m saying this, but I like Microsoft Word’s new default font better

[ad_1]

Change is hard – and for font nerds, it can be downright painful. They really feel the difference between Arial and Helvetica, and they know that Comic Sans is an embarrassment, and that Papyrus might be pure evil.

I’m not necessarily one of those people, but I don’t appreciate change – especially in fonts.



[ad_2]

Source Article Link

Categories
Life Style

what it means for cancer treatment

[ad_1]

Coloured scanning electron micrograph of T-lymphocyte killer cells attacking a cancer cell.

T cells (blue; artificially coloured) attack a cancer cell (red).Credit: BSIP Lecaque/Science Photo Library

More than 35 years after it was invented, a therapy that uses immune cells extracted from a person’s own tumour is finally hitting the clinic. At least 20 people with advanced melanoma have embarked on treatment with what are called tumour-infiltrating lymphocytes (TILs), which target and kill cancer cells.

The regimen, called lifileucel, is the first TIL therapy to be approved by the US Food and Drug Administration (FDA). And it is the first immune-cell therapy to win FDA approval for treating solid tumours such as melanoma. Doctors already deploy immune cells called CAR (chimeric antigen receptor) T cells to treat cancer, but CAR-T therapy is used against only blood cancers such as leukaemia.

TILs are a type of naturally occurring immune cell called a T cell. TILs recognize targets, called antigens, on the surfaces of cancer cells and burrow into solid tumours to kill them. They are the brainchild of Steven Rosenberg, a cancer researcher and surgeon at the National Cancer Institute in Bethesda, Maryland, who first showed1 that TILs could shrink tumours in people with melanoma. In clinical trials, TIL treatment has put some people with melanoma in remission for up to 20 years.

The FDA granted approval on 16 February to lifileucel, sold as Amtagvi by biotechnology company Iovance Biotherapeutics, based in San Carlos, California. The approval “is a great accomplishment”, says TIL specialist Nick Restifo, chief scientist at Marble Therapeutics in Boston, Massachusetts. He says that it will pave the way for TILs to be used to treat other cancers, including lung and pancreatic tumours, in the near future.

Nature spoke with scientists about TIL therapy and its future.

How are TILs made and used?

After a person’s tumour is removed, surgeons send tissue samples to a laboratory that isolates TILs from them and grow the TILs for three weeks until they’ve multiplied into billions of cells. Before the TILs are reinfused back into the treated person, the recipient is given chemotherapy and an immune chemical called interleukin-2 (IL-2) that temporarily kills immune cells to make room for the TILs.

For now, lifileucel can be used only as a last-line treatment in people with certain forms of advanced melanoma that haven’t responded to other treatments. But Iovance and others are currently testing lifileucel as a first-line treatment against melanoma. Some evidence suggests that it might be even more effective as a first- or second-line treatment, before an aggressive treatment can harm the TILs in tumours.

How effective are TILs?

In Iovance’s trial testing lifileucel in 153 people with melanoma, tumours shrank in 31% of the participants2. And in a second trial in Denmark, 20% of people who received TIL therapy went into complete remission, compared with 7% of those who received a different drug3.

Amod Sarnaik, a surgical oncologist at the Moffitt Center in Tampa, Florida, who led Iovance’s trial, says that solid tumours can generally become resistant to treatments such as chemotherapy. But removing most of the tumour and infusing billions of TILs is often enough “brute force” to overcome the cancer, Sarnaik says. The immune system then ‘remembers’ the most effective TILs, allowing it to quickly churn them out if the cancer comes back.

What are the side effects?

Most of the therapy’s side effects, such as anaemia and fevers, come from the chemotherapy and IL-2 treatments used to prepare patients for TIL infusion. But Sarnaik says that there is a risk of “friendly fire” if TILs also attack normal cells alongside the tumour cells. This can cause autoimmune conditions such as vitiligo, in which TILs cause skin discolouration by attacking pigment cells.

How are TILs regulated?

Similar to CAR T cells, TILs are naturally occurring cells that are specific to each person. But whereas CAR T cells are genetically engineered to attack specific antigens on cancer cells, no one knows which antigens any particular person’s TILs target — although it largely doesn’t matter, as long as they work for the individual person. “It’s a different drug literally for every patient,” Restifo says.

Because it’s impossible for the FDA to assess every patient’s set of TILs, the agency instead approved the process that Iovance uses to multiply the cells and the way that they are administered to people with cancer. And because TILs occur naturally, companies can patent only their processes and not the cells overall. “It’s good news for all of us trying to develop different ways of improving on the process,” Sarnaik says.

How much will the treatment cost?

Iovance has said that it plans to charge US$515,000 for the treatment, making it even more expensive than some of the six CAR-T therapies approved in the United States.

But other approaches might make TILs more affordable, says Inge Marie Svane, a cancer immunologist at Copenhagen University Hospital who is running TIL trials in Europe. Several university hospitals are growing TILs for melanoma without a company’s involvement, using a process that costs about €50,000 (US$55,000).

What’s next for TILs?

Dozens of companies are developing TILs for other types of tumours, and some have already proven effective against cervical4 and lung5 cancer. Researchers are developing improvements such as genetic manipulations that make TILs better at infiltrating and killing tumours. Svane, for instance, is about to start a clinical trial of TILs that are missing a gene that allows cancerous cells to kill them. “What we want to achieve is complete remission,” she says.

[ad_2]

Source Article Link