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Support for the original Oculus Quest headset will soon end as Meta has sent out emails to developers informing them of the company’s future plans for the device. Forbes managed to get their hands on the details, and according to their report, the tech giant is going to be strict. They really do not want the headset to stick around.
Developers have until April 30 to roll out any “app updates for the Quest 1 to the Meta Quest store.” Past that date, nothing will be allowed to be released even if dev teams want to continue catering to users of the older model. Meta will outright block the patch.
If an app is available on other Quest devices, the update can roll out to those headsets, but the Quest 1 support will be denied. New apps that come out after April 30 are not going to appear on the online store nor will owners even be allowed to buy them. They’ll be stuck in limbo.
The email continues by saying Meta will maintain the Quest 1 by releasing “critical bug fixes and security patches” until August of this year. Once the summer is over, the company will be wiping its hands clean, marking the official end of its first mainline headset. Users who want to continue on the platform will need to upgrade to either a Quest 2 or Quest 3.
Depreciation
The depreciation of the Quest 1, as sudden as it may seem, has been a long time coming. Meta originally announced the end of the headset back in January 2023. Soon after, it began to periodically pull the plug on certain features. Upgrades eventually grinded to a halt, people lost the ability to create parties, and lost access to the social aspects of Horizon Home.
Meta is turning the Quest 1 into a plastic brick as it cuts off support without any wiggle room. However, it’s possible that the headset could see new life among niche online communities or platforms like SideQuest. No one is stopping independent developers from sideloading apps. If you plan on joining these groups, keep in mind the software you download from unofficial spaces could come with malware. Meta isn’t going to come in and save you. You’re on your own.
Analysis: is the Quest 2 next?
Despite knowing all this would happen ahead of time, the Quest 1 cutoff is harsh to say the least especially when you compare it to gaming consoles. The headset didn’t even reach its fifth birthday before getting the ax. Consoles, on the other hand, often see many more years of support, sometimes a full decade’s worth. Seeing the shutdown makes us wonder what’s going to happen to the Quest 2.
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The second-gen model was released about a year-and-a-half after the original headset. Although it brought many improvements at launch, the performance of the Quest 2 has been eclipsed by other headsets. It could potentially see a similar end, although we think it’s unlikely. The Quest 2 has proven itself to be much more popular than the original, so a sudden cutoff likely won’t happen any time soon. It should exist as the brand’s mid-range option moving forward.
If you’re affected by the shutoff and want a new device, check out TechRadar’s list of the best VR headsets for 2024.
Johnblack Kabukye struggles to explain to his colleagues back home in Uganda why he’s doing a two-year stint as a postdoctoral researcher in Sweden. “If you say you’re doing a master’s or a PhD, it’s clear what that means,” says the digital-health specialist, who worked as a physician for a decade before switching to research. But a postdoc? “It’s not a thing that is understood,” he says.
The skills he’s learning at Stockholm University while building electronic health tools tailored to patients’ needs are certainly useful for his job as a physician and informatician at the Uganda Cancer Institute (UCI) in Kampala. But the postdoc format itself — a short-term position designed to bridge the gap between doctoral student and tenured academic — makes little sense in Uganda, where it is common to have a permanent teaching job at a university before even embarking on a PhD.
“I have not heard of a single postdoc opportunity in Uganda,” Kabukye says.
Career resources for African scientists
That could soon change across Africa. The number of people gaining PhDs in the continent is growing, and so is the need for postdoctoral employment. “There is definitely greater awareness of the postdoc position, and more and more postdocs,” says Gordon Awandare, pro-vice-chancellor in charge of academic and student affairs at the University of Ghana in Accra.
But as the continent’s postdoctoral employment needs have grown, so too have fears that the problems created by a proliferation of postdoc positions in other parts of the world — which critics say trap young researchers in a cycle of poorly paid, short-term positions with no job security — could also arise in African countries.
Breaking ground
Postdoc frustration is a recurring theme in studies that look at early-career researchers. Two global surveys of postdoctoral students by Nature, one published in 2020 and the other last year, found that more than one-third of respondents were dissatisfied with their lot. A lack of job security, career-advancement opportunities and funding were the most-cited reasons.
Nature’s surveys underscore the dearth of postdoctoral researchers in Africa. Of the 3,838 postdocs surveyed in June last year, only 91 were based on the continent. The number of respondents (who were self-selecting) were too few, and too geographically concentrated in three countries — South Africa, Nigeria and Egypt — to be viewed as representative of the continent. Yet, they offer tantalizing glimpses of an emerging segment of the global research workforce.
For example, African postdocs were older than the global average, with more than 40% aged 41 or older. They were also more likely to be doing their postdoc in their home country (68% in Africa compared with 39% globally) and they were much less likely, than the global average, to be employed on fixed-term fellowships or contracts (see ‘Employment matters’). Their pay also stands out: 60% said they earned less than US$15,000 per year — the lowest option survey-takers could tick, and a fraction of what most postdocs are paid in Europe and North America. Lower costs of living play some part in the lower salaries, but not enough to justify the gap (see ‘A continental shift’).
Postdocs in Africa were also more likely to report having a second job alongside their postdoc than were other respondents, on average (33% of respondents in Africa, compared with 10% of respondents overall). The most common reason was to provide extra income (71%), while 57% said their second job gave their skills and career prospects a boost. However, notes Awandare, the tendency of many African postdocs to have permanent academic positions before becoming a postdoc could be a confounding factor in this measure.
Yet, and perhaps surprising given their low pay, Africa-based postdocs were the most optimistic about their futures of all respondents from the geographical regions represented. Overall, 64% of Africa-based respondents reported that they felt positive about their future job prospects, compared with 41% globally. Postdocs in Africa were twice as likely to say that their postdoc roles were better than they imagined (25% compared with 12% overall). And 42% of respondents in Africa felt that they had better prospects than previous generations of postdocs, far exceeding the 15% global average.
That optimism makes sense to Awandare, who thinks that postdocs in his country might feel more important than do their peers who work in large laboratories overseas. In addition to his leadership role at the University of Ghana, he founded and runs the West African Centre for Cell Biology of Infectious Pathogens at the university. He says postdocs at the centre are treated the same as faculty members. “In some advanced institutions, they wouldn’t get that recognition and status,” he notes.
And even though their salaries are low by international standards, postdocs at his centre can be better paid than entry-level permanent university staff who only teach, he says. This is because postdocs tend to be paid out of lucrative international grants. “Ten to fifteen years ago, many of these positions would have been overseas — but now funders, to their credit, increasingly provide positions on the continent,” he says.
A different set-up
Employment structures also differed between Africa and the rest of the world, according to Nature’s survey. Although similar proportions of postdocs were employed in academia in Africa as they were globally (around 90%), the proportion of part-time postdocs was higher in Africa — 12% compared with the global average of 5%. One of them is Felista Mwingira, a parasitologist at the University of Dar es Salaam in Tanzania. She exemplifies how African early-career researchers have been forging ahead in their research careers in the absence of a formal structure of postdoc positions.
Mwingira obtained her PhD in 2014 from the University of Basel in Switzerland at the age of 33 — which she says is very young for researchers in Tanzania. By the time she started her studies, she was already permanently employed by her university in Tanzania, and was able to return to that post after finishing her PhD. Back home, she could take three months paid maternity leave for each of her two children, born four years apart. And although juggling pregnancies and bringing up children with the demands of an academic career was a challenge, it meant she had job security — something postdocs at the same stage in their lives in other parts of the world often lack.
Falling behind: postdocs in their thirties tire of putting life on hold
Mwingira’s work after her PhD was not technically a postdoc. But as her children got older, she sought out a mentorship arrangement at her university that provides her with research training and, sometimes, extra money from the projects she works on. It’s not a formal postdoc, but she hopes it will help her to attain the publication ‘points’ required in the Tanzanian university system to progress up the academic career ladder — something that does not depend on more-senior positions becoming available. She hopes to be promoted in the near future, but says she would also like to embark on a full-time postdoc position to “sharpen my scientific skills”.
So far, Mwingira considers herself lucky. Her children are now four and eight, and while she says that her life as an early-career academic still has ups and downs, she is thankful for the stability she has enjoyed so far in her career. “I think that I’m better off compared to postdocs in high-income countries.”
That feeling of being better off than people elsewhere certainly does not translate to sub-Saharan Africa’s most prominent research nation: South Africa. There, postdoc numbers have been rising for a couple of decades, growing from around 300 in 1999 to nearly 3,000 in 2019 (ref. 1), and national surveys reveal postdoc frustrations that mirror those raised globally, with some country-specific gripes to boot.
Heidi Prozesky is a research scholar at the Centre for Research on Evaluation, Science and Technology at Stellenbosch University. She is one of the people behind South Africa’s first PhD tracer study, published in its final form in July 2023, which tracked the whereabouts of nearly 6,500 PhDs who had graduated in the country between 2010 and 2019. That survey found that around 20% had accepted at least one postdoctoral fellowship, either at home or abroad, on completing their PhDs, with a steady growth seen over the two decades. The postdocs spent a median of three years in the position, although one-quarter reported spending more than four years. One-third reported having accepted more than one postdoc — often, they said, because other work was not available.
Career resources for postdoctoral researchers
A common refrain in the South African survey, which echoes the findings of Nature’s global surveys, is that postdocs feel like they are in limbo: neither students nor staff. In reality, postdocs in South Africa are technically students. This saves them from paying tax on their income, which are stipends, not salaries. But this designation also breeds resentment, because it means postdocs are treated like students: they can’t apply for grants and typically have no funding to travel to conferences or attend workshops.
In addition to the lack of opportunities, postdoc pay in South Africa is low compared with living costs. Last year, the National Research Foundation’s non-taxable postdoc stipends started at 200,000 rand (US$10,700). Female postdocs are allowed up to four months paid maternity leave. However, basic private medical insurance does not come as standard, meaning that postdocs have to pay for it out of their stipends if they want to avoid state health care, which many people in South Africa view as woefully inadequate. The stories of some postdocs “would make you cry”, says Palesa Mothapo, who heads research support and management at Nelson Mandela University in Port Elizabeth, South Africa. “These people have PhDs. And they end up going hungry.”
Growing pains
South Africa’s predicament stems partly from bottlenecks in the academic careers system. The number of people with a PhD graduating annually more than tripled between 2000 and 2018, increasing the demand for postdoctoral work. Postdoc positions have also increased, but further up the career ladder, the number of roles has been static. A study published this year1 in the South African Journal of Science found that the number of postdoc positions grew ten times faster between 2007 and 2019 in the country than did the growth in entry-level permanent jobs in academia.
Palesa Mothapo at Nelson Mandela University in Port Elizabeth, South Africa, says there needs to be more discussion around transferable skills for African postdocs.Credit: Stefan Els
But many also view South Africa’s postdoc malaise as a consequence of incentive structures in the country that place a premium on research publications. Postdocs have become cheap, low-commitment hires for universities that want to boost their output of research publications, which in South Africa earn the host institutions or departments cash subsidies from the government. Postdocs often have publication targets written into their appointments, Mothapo says. “But those papers don’t translate to money for the postdoc. It goes to the institution, to the host.”
There is some cause for cheer. Last December, the National Research Foundation announced it would raise its minimum annual postdoc stipend to 320,000 rand per year for new fellowships from 2024. But simply increasing postdoc stipends is unlikely to create more academic positions for postdocs who are looking for more job security. And the bottleneck seems to be worse for some groups. According to Prozesky, South Africa attracts a lot of postdocs from the rest of the African continent. Most come with the expectation that it will lead to a permanent job. The PhD tracer study found that many people from the rest of Africa end up disillusioned and feeling discriminated against. They struggle to move on from the postdoc status, and can face long delays in visa approvals when moving between posts. “They call it academic xenophobia,” says Prozesky.
Charles Teta, a Zimbabwean environmental chemist who did two postdocs in South Africa after a PhD in his home country, says that he noticed that South African citizens were less likely to take the postdoc route than were immigrants like him. “South Africans are more likely to get lectureship posts,” without having any postdoc experience, he says. In addition, a growing number of funding streams are not open to non-citizens — even those who are permanent residents. Eventually, those restrictions cause people to leave, he says.
Teta left South Africa last year to cover the maternity leave of an environmental-science lecturer at Queen Mary University of London. There, he enjoys the opportunity to teach — something he wasn’t expected to do during his postdocs. It’s been a happy choice so far, and he hopes to find another, similar position when his current one ends. He doesn’t miss the research treadmill, which, he says, “did not translate to mental and financial well-being”.
A call for creativity
Mothapo says that the rigid focus on research in South African postdoc roles is part of their problem. “The universities are not creative,” she says. Because postdocs are limited in how they can teach, and can’t apply for their own funding, she notes, they are missing out on learning skills that are beneficial for staying in academia, and that could open up alternative career paths in industry.
More-creative programmes have been trialled across the continent. Since 2019, the US National Institutes of Health (NIH), the Bill & Melinda Gates Foundation in Seattle, Washington and the African Academy of Sciences have been running the African Postdoctoral Training Initiative (APTI). The programme combines a two-year postdoc at a NIH institute in the United States with a two-year research grant that fellows can take back home to build their own research programmes. Notably, it is open only to researchers who have permanent positions already.
Postdoc career optimism rebounds after COVID in global Nature survey
Daniel Amoako-Sakyi, an immunologist at the University of Cape Coast, Ghana, embarked on an APTI fellowship in late 2023. He is a postdoc in mid-life, and the fellowship has proved to be a good fit. He is a few months into his position at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, where he will spend the next two years looking at biological reasons for the variance in efficacy seen in new malaria vaccines. His 15-year-old daughter has enrolled in a US high school, and his spouse, a fellow academic, aims to split her time between the United States and Nigeria.
In Bethesda, Amoako-Sakyi has none of the resource constraints that limit him in Ghana. Antibodies that would take months to ship to his home country arrive on his doorstep overnight. He expects the opportunity will supercharge his career, and hopes he’ll be able to take on some postdocs of his own when he returns home. He doesn’t expect it will be difficult to find them. “I think most researchers are looking for the right environment to flourish,” he says.
What comes next?
There are few certainties about the future of African postdocs. Those who spoke to Nature hope that their postdoc training will accelerate their careers — by helping them to win grants, get promotions and expand their research networks. In Uganda, Kabukye hopes to have organized funding and collaborators by the end of his postdoc so that he can carry on his research designing and implementing digital-health tools in resource-constrained settings. “Ideally, I would have positions at the UCI and at another university, to foster collaboration and exchange,” he says.
Physician Johnblack Kabukye from Uganda is doing a postdoc building electronic health tools at Stockholm University in Sweden.Credit: Johnblack Kabukye
However, with most of the continent’s research funding still coming from sources outside Africa — with the exception of a handful of countries, such as South Africa and Egypt — it’s likely that foreign funding will keep driving the creation of postdoc opportunities. And that can mean the positions aren’t always tailored to local needs.
Mothapo says that she often hears research funders talk about the need to create more postdoc positions. However, there is not enough discussion around the particular needs that African postdocs will have, especially the transferable skills that they will need if they want to transition to sectors such as industry. “I’m worried about their destinations,” she says.
Mwingira echoes her concern. She thinks that more formalized postdocs in Tanzania could lead to bottlenecks in the training system, as has been seen in South Africa and elsewhere. “Those problems will arise in Tanzania, too, but worse, because of the low salaries,” she says.
But Amoako-Sakyi does not think that the creation of more African postdocs has to result in frustration as they compete for rare academic posts. Many might already be employed by universities at that point in their careers. A postdoc could allow them to win grants from funders so that they can set up their own research groups and create opportunities for the next generation. He also thinks that the biotechnology industry in countries such as Ghana will grow, further increasing the demand for researchers in the country.
Nor does Amoako-Sakyi think that African postdocs need to end up in the same negative landscape that postdocs occupy elsewhere in the world. Such fears are not unfounded, he says, because concepts are often brought to the continent and adopted without thinking about the local context. But as his own fellowship shows, there are ways to tailor postdocs to African settings. “We should be very intentional about how we do it and try to correct old mistakes.”
Samsung has revealed it expects to triple its HBM chip production this year.
“Following the third-generation HBM2E and fourth-generation HBM3, which are already in mass production, we plan to produce the 12-layer fifth-generation HBM and 32 gigabit-based 128 GB DDR5 products in large quantities in the first half of the year,” SangJoon Hwang, EVP and Head of DRAM Product and Technology Team at Samsung said during a speech at Memcon 2024.
“With these products, we expect to enhance our presence in high-performance, high-capacity memory in the AI era.”
Snowbolt
Samsung plans a 2.9-fold increase in HBM chip production volume this year, up from the 2.5-fold projection previously announced at CES 2024. The company also shared a roadmap detailing its future HBM production, projecting a 13.8-fold surge in HBM shipments by 2026 compared to 2023.
Samsung used Memcon 2024 to showcase its HBM3E 12H chip – the industry’s first 12-stack HBM3E DRAM – which is currently being sampled with customers. This will follow Micron’s 24GB 8H HBM3E into mass production in the coming months.
According to The Korea Economic Daily, Samsung also spoke of its plans for HBM4 and its sixth-generation HBM chip which the company has named “Snowbolt,”. Samsung says it intends to apply the buffer die, a control device, to the bottom layer of stacked memory for enhanced efficiency. It didn’t provide any information on when that future generation of HBM will see the light of day, however.
Despite being the world’s largest memory chipmaker, Samsung has lagged behind archrival SK Hynix in the HBM chip segment, forcing it to invest heavily to boost production of what is a crucial component in the escalating AI race due to its superior processing speed.
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SK Hynix isn’t going to make things easy for Samsung however. The world’s second largest memory chip maker recently announced plans to build the largest chip production facility ever seen at Yongin Semiconductor Cluster in Gyeonggi Province, South Korea.
A person has received an experimental treatment for the first time that, if successful, will lead them to grow an additional, ‘miniature liver’. The procedure, developed by the biotechnology firm LyGenesis, marks the beginning of a clinical trial designed for people whose livers are failing, but who have not received an organ transplant.
First pig liver transplanted into a person lasts for 10 days
The approach is unusual: researchers injected healthy liver cells from a donor into a lymph node in the upper abdomen of the person with liver failure. The idea is that in several months, the cells will multiply and take over the lymph node to form a structure that can perform the blood-filtering duties of the person’s failing liver.
“It’s a very bold and incredibly innovative idea,” says Valerie Gouon-Evans, a liver-regeneration specialist at Boston University in Massachusetts, who is not involved with the company.
The person who received the treatment, on 25 March, is recovering well from the procedure and was discharged from the clinic, says Michael Hufford, chief executive of LyGenesis, which is based in Pittsburgh, Pennsylvania. But physicians will need to closely monitor them for infection because the person needs to take immunosuppressive drugs so that their body doesn’t reject the donor cells, says Stuart Forbes, a hepatologist at the University of Edinburgh, UK, who is not affiliated with LyGenesis.
Organ crisis
More than 50,000 people in the United States die each year with liver disease. In the end stage of the disease, scar tissue that has accumulated prevents the organ from filtering toxic substances in the blood, and can lead to infection or liver cancer.
A liver transplant can help, but there is a shortage of organs: about 1,000 people in the United States die every year waiting for a transplant. Thousands more aren’t eligible because they are too ill to undergo the procedure.
A person received donor liver cells on 25 March that were injected into one of their lymph nodes.Credit: LyGenesis
LyGenesis has been trialling an approach that could help people in this situation — and make use of donated livers that would otherwise go to waste because a person on the transplant waiting list with a compatible health profile hasn’t materialized in time. The company’s strategy delivers the donor cells through a tube in the throat, injecting them into a lymph node near the liver. Lymph nodes, which also filter waste in the body and are an important part of the immune system, are ideal for growing mini livers, Hufford says, because they receive a large supply of blood and there are hundreds of them throughout the body, so if a few are used to generate mini livers, plenty of others can continue to function as lymph nodes.
The treatment has so far worked in mice1, dogs and pigs2. To test the therapy in pigs, researchers restricted blood flow to the animals’ livers, causing the organs to fail, and injected donor cells into lymph nodes. Miniature livers formed within two months and had a cellular architecture resembling a healthy liver. Researchers even found cells that transport bile, a digestive fluid produced by the liver, in the mini livers of the pigs. In this case, they saw no build-up of bile acid, suggesting that the mini organs were processing the fluid.
Hufford says there’s reason to think that the organs won’t grow indefinitely in the lymph nodes. The mini organs rely on chemical distress signals from the failing liver to grow; once the new organs have stabilized blood filtering, they will stop growing because that distress signal disappears, he says. But it’s not yet clear precisely how large the mini-livers will become in humans, he adds.
The company aims to enrol 12 people into the phase II trial by mid-2025 and publish results the following year, Hufford says. The trial, which was approved by US regulators in 2020, will not only measure participant safety, survival time and quality of life post-treatment, but will also help to establish the ideal number of mini livers to stabilize someone’s health. The clinicians running the trial will inject liver cells in up to five of a person’s lymph nodes to determine whether the extra organs can boost the procedure’s success rate.
A stop-gap measure
However, mini livers might not relieve all of the complications of end-stage liver disease, says Forbes, who has formed his own company to tackle liver disease using genetically modified immune cells that stimulate repair. One of the most serious of these is portal hypertension, in which the build-up of scar tissue compresses blood vessels in the liver and can cause internal bleeding.
Pig brains kept alive outside body for hours after death
Hufford acknowledges that the mini livers are not expected to address portal hypertension, but the hope is that they can provide a stopgap until a liver becomes available for transplant, or make people healthy enough to undergo a transplant. “That would be amazing, because these patients currently have no other treatment options,” Gouon-Evans says.
LyGenesis has ambitions beyond mini livers, too. The company is now testing similar approaches to grow kidney and pancreas cells in the lymph nodes of animals, Hufford says.
If the liver trial is successful, Gouon-Evans says, it would be worth investigating whether a person’s own stem cells could be used to generate the cells that seed the lymph nodes. This technique could create personalized cells that capture the diversity of cells in the liver and don’t require immunosuppressive drugs, she says.
While the initial hype over Apple Vision Pro may have died down, Apple is still busy developing and rolling out fresh updates, including a new one that lets multiple Personas work and play together.
Apple briefly demonstrated this capability when it introduced the Vision Pro and gave me my first test-drive last year but now spatial Personas is live on Vision Pro mixed-reality headsets.
To understand “spatial Personas” you need to start with the Personas part. You capture these somewhat uncanny valley 3D representations of yourself using Vision Pro’s spatial (or 3D) cameras. The headset uses that data to skin a 3D representation of you that can mimic your face, head, upper torso, and hand movements and be used in FaceTime and other video calls (if supported).
Spatial Personas does two key things: it gives you the ability to put two (or more) avatars in one space and lets them interact with either different screens or the same one and does so in a spatially aware space. This is all still happening within the confines of a FaceTime call where Vision Pro users will see a new “spatial Persona” button.
To enable this feature, you’ll need the visionOS 1.1 update and may need to reboot the mixed reality headset. After that you can at any time during a FaceTime Persona call tap on the spatial icon to enable the featue.
Almost together
(Image credit: Apple)
Spatial Personas support collaborative work and communal viewing experiences by combining the feature with Apple’s SharePlay.
This will let you “sit side-by-side” (Personas don’t have butts, legs or feet, so “sitting” is an assumed experience) to watch the same movie or TV show. In an Environment (you spin the Vision Pro’s digital crown until your real world disappears in favor of a selected environment like Yosemite”) you can also play multi-player games. Most Vision Pro owners might choose “Game Room”, which positions the spatial avatars around a game table. A spatial Persona call can become a real group activity with up with five spatial Personas participating at once.
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Vision Pro also supports spatial audio which means the audio for the Persona on the right will sound like it’s coming from the right. Working in this fashion could end up feeling like everyone is in the room with you, even though they’re obviously not.
Currently, any app that supports SharePlay can work with spatial Personas but not every app will allow for single-screen collaboration. If you use window share or share the app, other personas will be able to see but not interact with your app window.
Being there
Freeform lets multiple Vision Pro spatial Personas work on the same app. (Image credit: Apple)
While your spatial Personas will appear in other people’s spaces during the FaceTime call, you’ll remain in control of your viewing experience and can still move your windows and Persona to suit your needs, while not messing up what people see in the shared experience.
In a video Apple shared, it shows two spatial Personas positioned on either side of a Freeform app window, which is, in and of itself somewhat remarkable. But things take a surprising turn when each of them can reach out with their Persona hands to control the app with gestures. That feels like a game-changer to me.
In some ways, this seems like a much more limited form of Meta CEO Mark Zuckerberg’s metaverse ideal, where we live work and play together in virtual reality. In this case, we collaborate and play in mixed reality while using still somewhat uncanny valley avatars. To be fair, Apple has already vastly improved the look of these things. They’re still a bit jarring but less so than when I first set mine up in February.
I haven’t had a chance to try the new feature, but seeing those two floating Personas reaching out and controlling an app floating a single Vision Pro space is impressive. It’s also a reminder that it’s still early days for Vision Pro and Apple’s vision of our spatial computing future. When it comes to utility, the pricey hardware clearly has quite a bit of road ahead of it.
Dozens of genetic factors have been associated with left-handedness, which occurs in roughly one in ever ten people.Credit: incamerastock/Alamy
To what extent do genes determine how you pick up your morning cup of coffee? Researchers examined rare genetic variants from a database of more than 350,000 individuals’ genetic data to hunt for clues for what influences handedness in humans. Their findings implicate tubulins — proteins that build cells’ internal skeletons.
The results, published on 2 April in Nature Communications1, were obtained specifically at protein-coding parts of the DNA, and add to previous studies that linked genetic variations with handedness .
“This is an important and significant study” that supports tubulins’ involvement in determining the left–right brain asymmetry, says Sebastian Ocklenburg, a neuroscientist at the Medical School Hamburg in Germany.
During the embryonic stage of human development, the left and right brain hemispheres get wired differently, which in part determines innate behaviours, such as where we lean when we hug someone, on which side of our mouth we tend to chew our food and, most prominently, which hand is our dominant one. This turns out to be the left hand for around 10% of the human population.
Because most people have a clear preference for one hand over the other, finding genes linked to handedness can provide clues for the genetic basis of the brain’s left–right asymmetry.
Previous studies looking at genome-wide data from UK Biobank2 found 48 common genetic variants associated with left-handedness, which were mostly in non-coding regions of the DNA. These included sections that could control the expression of genes related to tubulins. These proteins assemble into long, tube-like filaments called microtubules, which control the shapes and movements of cells.
But Clyde Francks, a geneticist and neuroscientist at the Max Planck Institute for Psycholinguistics in Nijmegen, the Netherlands, and his team looked for genetic variants in protein-coding sequences. Their analysis of 313,271 right-handed and 38,043 left-handed individuals’ genetic data, from the UK Biobank, uncovered variants in a tubulin gene, dubbed TUBB4B, which were 2.7 times more common in left-handed people than in right-handers.
Microtubules could influence handedness because they form cilia — hair-like protrusions in cell membranes — which can direct fluid flows in an asymmetric way during development.
In spite of affecting only a small proportion of the people in this considerable data set, rare variants “can give clues to developmental mechanisms of brain asymmetry in everyone”, Francks says. He adds that these findings pave the way for future work to determine how microtubules, which themselves have a molecular ‘handedness’, can give an “asymmetric twist” to early brain development.
April’s new Xbox Game Pass arrivals give you Lego racing, Lara Croft and a Lil Gator. Subscribers can play the Mario Kart-like Lego 2K Drive starting on Wednesday, the trilogy-wrapping Shadow of the Tomb Raider on April 11 and the charming stop-motion adventure game Harold Halibut on April 16.
Lego 2K Drive, launched in May 2023, lets developer Vision Concepts (known for the NBA 2K and WWE 2K series) take the reins from Travelers’ Tales to create its first Lego game. We were quickly pulled in by its charming vehicle transformations and quirky fun in a game that draws equally from Mario Kart and Forza Horizon 5.
Our gripes (no quick way to restart races and a suspicious nudge toward microtransactions) will be easier to see past when you can download it for free with your Game Pass subscription. Lego 2K Drive will be available to Game Pass members on April 3 for cloud and Xbox consoles.
Shadow of the Tomb Raider: Definitive Edition wraps up Lara Croft’s Survivor Trilogy origin story, which rebooted the series as an Uncharted-esque cinematic epic. Help Croft traverse jungles, caverns and ruins (with tombs!) as she battles the mysterious and all-powerful organization Trinity and completes her transformation into the character known and loved from previous iterations. You can play it on April 11 on cloud, Xbox consoles and PCs.
Slow Bros.
Harold Halibut is a quirky adventure game made in the spirit of old-school Sierra or LucasArts games — with a unique visual twist. Harold works as a lab assistant in a sunken spaceship trapped underwater 250 years after fleeing a doomed Earth. But the game’s stop-motion digital animation steals the show, appropriately illustrating the story’s captivatingly gloomy sci-fi premise.
Developer Slow Bros. created handmade characters, environments and objects, which were scanned and animated digitally, leading to a stand-out old-school motif. Harold Halibut will be available on April 16 on cloud, PC and Xbox Series X/S.
Also available for Game Pass members in April are the time-slowing action-puzzler Superhot: Mind Control Delete (available Tuesday for cloud, console and PC), the innocently family-friendly open-world adventure Lil Gator Game (April 4: cloud / console / PC), EA Sports PGA Tour (April 4: cloud / PC / Xbox Series X/S) and surreal detective game Kona (April 9: cloud / console).
Leaving Xbox Game Pass this month are Amnesia Collection, Amnesia: Rebirth, Back 4 Blood, Phantom Abyss, Research and Destroy and Soma. They’re available until April 15.
Nubia itself has confirmed that the Flip 5G – which is known in selected regions as the ZTE Libero Flip – will officially launch in Europe on April 9 as part of a global reveal event. Set to kick off at 7am ET / 4am PT / 12pm BST, this event will presumably play host to a pricing and release date announcement, since we’ve already handled the Flip 5G in-person.
At MWC 2024, Nubia teased that the Flip 5G will be available in Africa, Europe, Latin America, the Middle East and Southeast Asia for the local equivalent of $599, though pricing could vary with different specs in different markets. There’s a good chance that the phone will ship in the US, too, albeit at a later date (and potentially through third-party retailers rather than Nubia itself). An Australian release seems unlikely, though.
The Flip 5G now has a dedicated page on Nubia’s website, and UK shoppers can currently get £20 off by signing up to the company’s mailing list (you’ll also be entered into a free Nubia Flip 5G giveaway for your troubles).
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(Image credit: Future / Axel Metz)
(Image credit: Future / Axel Metz)
(Image credit: Future / Axel Metz)
(Image credit: Future / Axel Metz)
As for what we already know about the device, the Nubia Flip 5G sports a 6.9-inch folding AMOLED display (1188 x 2790) with a 120Hz refresh rate, as well as a versatile external display that can function as a camera, a calendar, a stopwatch, and more.
Under the hood, the Nubia Flip 5G is powered by Qualcomm’s mid-range Snapdragon 7 Gen 1 chipset, and a 4,310mAh battery with 33W fast charging. For comparison, the Samsung Galaxy Z Flip 5 boasts an objectively faster Snapdragon 8 Gen 2 chipset, but that phone will set you back an almighty $999.99 / £1,049 / AU$1,649 (its 3,700mAh battery is significantly smaller, too).
On the cameras front, Nubia’s upcoming foldable is equipped with a 50MP wide lens, a 50MP telephoto lens and a 16MP selfie camera. Again, for comparison, the Galaxy Z Flip 5 sports a numerically lesser 12MP wide lens, 12MP ultra-wide lens and 10MP selfie camera, though the superior processing power of Samsung’s latest flip-style foldable could see it outperform the Nubia for image quality.
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That said, the Nubia Flip 5G boasts an impressive suite of specs for its as-yet-announced $599 price tag; it’s all-but-certain to be half the price of the Galaxy Z Flip 5, but it’s much more than half the phone. As for whether the Nubia Flip 5G will earn a spot on our list of the best foldable phones, the jury is out, but it could well end up being the best cheap phone of its kind. Roll on April 9!
It’s spring cleaning season, but that doesn’t mean you need to get on the floor and scrub. Robot vacuums are a great way to keep your home clean while doing little to nothing, and a few robovacs from Shark are currently on sale. One of the best deals comes courtesy of a 44 percent discount on Shark’s AI Robot Vacuum and Mop. The device is down to $270 from $480 — only $20 more than its all-time low price.
Shark
Shark’s AI Robot Vacuum and Mop is a great option for anyone looking to try a robot vacuum or upgrade their entry-level model. It’s nearly identical to Shark’s much pricier Ultra 2-in-1 Robot Vacuum and Mop, which appears on our list of the best robot vacuums for 2024 — it just doesn’t have a self-emptying base.
The AI Robot Vacuum and Mop does have quite a few gadgets, including home mapping and AI laser navigation for detecting row-by-row precision and detecting objects four inches or taller. The mop executes 100 scrubs per minute and follows no-mop zones. You can use UltraClean mode on specific, busier rooms, with Shark claiming vacuum work 30 percent better at cleaning carpets in the setting.
The concept of inkjet printing was a fixture throughout the 20th century – with research starting way back in the 50s with a Japanese Canon employee, Ichiro Endo, who proposed the idea for a “bubble jet” printer that could translate the images you see on a computer to a printed physical page. But it wasn’t until HP‘s ThinkJet printer launched in 1984 that inkjet printing truly entered the mainstream – and with it the dreaded ink cartridge.
One of the first commercial inkjet printers was the IBM 6640, a device designed to offer printing to offices, when it was launched in 1976. It was part of a handful of bulky, heavy and impractical devices that launched around this time – and offered inkjet printing in professional contexts.
But nearly ten years later, HP brought out a more compact machine for personal printing at home. Measuring 11.5 x 8 x 3.5 inches, the black-and-white printer would have set you back $495 – $1,478.45 by today’s standards. Its ink cartridges, which were available for $8 a pop ($24) were good for 500 pages too.
The dot-matrix disruptor
Its name is derived from the process of ‘thermal inkjet’ printing – and came about when an engineer working on a completely different project noticed something interesting about the effects of electricity. When they were making thin-film technology for integrated circuit applications, they were testing how a thin silicon film would respond when stimulated with electricity. To the engineer’s surprise, the electricity superheated the medium and droplets of fluid lying beneath the film were expelled. This, according to HP, inspired the idea for finely controlled jets of fluid in a compact inkjet printer.
This invention was a game-changer. While, as we’ve mentioned, inkjet printing was in force across enterprises – these machines could only print large characters rather crudely. Now, it was clear this technology could be reduced in size and operate with relatively little power compared to its business-centric cousin.
It also marked an end to the dot-matrix printer, which was replaced a technology that was better in almost every metric – to the extent it’s still one of the most popular types of printer today. For instance, dot-matrix printers typically printed at 120 characters per second, while the HP ThinkJet printed at 150 characters per second. The former technology also emits high-pitch scratching sounds, too, while the inkjet printer emits a “nondistracting hum that is quiet enough not to interfere with telephone conversations,” according to InfoWorld (1984).
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