As a group, we were all of similar ability and speeds, so range rarely became an issue while skiing. When someone did fall back from the group, stop for a couple of minutes, or even turn a particularly big, rocky corner, we would get a “Jeremy is out of range” alert. The Milos work best with a straight line of sight, and for our resort riding needs were more than capable. They didn’t always work from the resort bar though, which meant drinks orders were missed, but we’re not blaming Milo for this. Not much, anyway.
We were also impressed by Milo’s Proximity Mute, which turns down the microphones when you’re close enough for a normal volume conversation. This worked well, with anyone not close enough still able to communicate through the speakers to the gathered group.
Recent software updates have also added some voice commands to Milo, with more expected soon. We weren’t able to test these, but they include one-on-one side chats, allowing you to talk to individuals in the group with a simple “OK Milo, speak with Chris” prompt.
Milo founder and CEO Peter Celinski also told WIRED they’re about to launch a Long Range Messaging Mode that will allow you to use voice commands to record and send messages to specific individuals in your group. You get a confirmation when your message has been received and recipients can play back messages at their leisure, including multiple times. This will be a handy extra, and another reason to keep your phone safely in your pocket.
Hardest Button to Button
Milo is intuitive and, once you appreciate its limitations, extremely useful. But it’s not without issues. With the exception of the massive main mute/unmute button, the rubber controls are bafflingly difficult to use wearing gloves, especially considering skiing is cited by the company as a prime activity for Milos (alongside kayaking, surfing, hiking, and surfing).
Using the main button also requires accuracy—we estimated an 70 percent first time hit rate, although this did improve with practice. It’s very irritating, too, that the volume of each Milo gets reset to low when powered down.
Curiously, Milo doesn’t give a specific battery life duration, but, for the most part, our devices survived a long day on the slopes, though that did require each person to power down their units at lunch to make it through to the last lift.
In a group, the Milos create a secure mesh network so comms are more stable.
Photograph: Wired
A maximum of six Milos can be linked in a group, which seems a little limited, but given the high price of buying multiple units it might be a blessing. At $249 a pop, can you persuade your mates to invest? Milo does offer group deals—great for families—with four units plus armband and action clips costing $925 instead of $1,120.
We’ve not tested Milo on bikes or water, but in the mountains we quickly learned to appreciate how useful they can be. Chatting as you ski, sharing tips, and generally enthusing about being in the mountains is fun—and being able to keep tabs on a group and help as necessary is a real bonus. And, remember, the free alternative of phone communication isn’t possible when surfing and the like.
If you’ve got cash to spend, we’re happy to recommend Milo, especially as the brand rolls out more voice- and AI-based features. If the price were a little lower, the battery life a little longer, and the fiddly volume buttons a little bigger, Milo’s modern take on walkie-talkies would be a clear win.
Sony made a special occasion of its 2024 TV launch, holding it at the Sony Pictures Studios lot in Los Angeles. At the event, attendees, myself included, were treated to demos of Foley effects and soundtrack mixing, plus other striking examples of behind-the-scenes movie magic that happens at the studio. Sony’s message was that the technology that goes into movie and TV creation via its studio and professional camera and display divisions trickles down into consumer products, and it was made loud and clear at the event.
The Sony Bravia 9 is the flagship model of the new Bravia series TVs, taking that crown from the Sony A95L OLED TV, which will continue in the lineup for 2024. Interestingly, the Bravia 9 is a mini-LED TV. That marks a change in direction for Sony, a brand that in the past had regularly positioned OLED as the most premium technology in its TV lineup.
Sony’s re-positioning of mini-LED at the top of the TV food chain results from two tech developments at the company. The first is the creation of the BVM-HX3110, a professional mastering monitor capable of 4,000 nits peak brightness. The BVM-HX3110 was introduced in late 2023, and replaces the BVM-HX310, a standard model for movie post-production that tops out at 1,000 nits peak brightness.
The backlight LED driver panel used in Sony’s Bravia 9 TVs. Those tiny black stripes are the mini-LED modules. (Image credit: Future)
The second development is XR Backlight Master Drive with High Peak Luminance, a new TV backlight technology used exclusively in the Sony Bravia 9 mini-LED TV. According to Sony, its next-gen backlight tech is responsible for a 50% brightness boost in the Bravia 9 over the company’s previous flagship mini-LED model, the Sony X95L, along with a 325% increase in local dimming zones – something it accomplishes through a new, highly miniaturized 22-bit LED driver.
Along with increasing the number of LED modules that can be positioned in a backlight, the new driver’s higher resolution (other TV makers use 10- or 12-bit drivers, according to Sony) in combination with advanced dimming control algorithms lets it display images with a greater level of refinement than previously available in the best TVs. And that’s where Sony’s demo of the new Bravia 9 TV I attended comes in.
Brightness refined
There were two components to Sony’s demonstration of the Bravia 9’s XR Backlight Master Drive with High Peak Luminance tech. The first was a comparison of the new Sony BVM-HX3110 monitor with the older BVM-HX310 using movie scenes mastered at 4,000 nits peak brightness. While most movies are mastered at 1,000 nits peak brightness, according to Sony that has mainly been a technology limitation – one now removed by the BVM-HX3110. When viewing the 4,000 nits footage on both monitors side by side, a clear increase in highlight detail on the new BVM-HX3110 made images look notably more dynamic.
Sony’s Bravia 9 mini-LED TV in a bright room setting. (Image credit: Future)
The second component was a stacked pair of Sony Bravia 9 TVs set alongside a stacked pair of Samsung QN90C TVs, that company’s flagship 2023 mini-LED model in the US. The TVs arrayed at the top had their LCD panels removed so we could see the “raw” mini-LED backlight (see pic at top). Viewing a series of video clips, the Sony’s backlight had notably higher “resolution” owing to the XR Backlight Master Drive’s more granular local dimming performance. It also had a punchier level of brightness that could be seen in images displayed on the normal, non-butchered versions of both TVs located below. That brightness made highlights pop more dramatically and colors look brighter and richer.
Equally impressive in the demo was the virtual absence of backlight blooming effects in the transitions between bright and dark parts of images on the Bravia 9. Backlight blooming is a common visual artifact with LED-based TVs, even ones that use mini-LED tech, and it’s a key reason why OLED TVs, which have panels with self-emissive pixels that generate their own light, have retained a picture quality advantage over LED TVs.
Mini-LED mastered
Another picture quality comparison conducted by Sony at the event put the Bravia 9 alongside the Sony X95L and Samsung S95C, that company’s 2023 flagship QD-OLED model. The comparison also used Sony’s BVM-HX3110 displaying the same images as a reference point, and of the three TVs, the Bravia 9 most closely tracked the picture on the professional mastering monitor.
While Sony hasn’t revealed peak brightness specs for the Bravia 9 TV, its ability to accurately reproduce highlight and shadow details in movies mastered at 4,000 nits makes it a statement piece for HDR. As Sony’s new mastering monitor makes its way into more production facilities and movie directors and cinematographers start pushing the limits of what the format is capable of, any TV that can handle that will have an advantage.
Sony’s shift to mini-LED for its flagship TV signals its confidence in the tech, and with developments such as XR Backlight Master Drive, its ability to compete effectively with OLED. The 2024 crop of OLED TVs is turning out to be the brightest yet, with the new Samsung S95D measuring just under 1,800 nits peak brightness in our tests. But the new Samsung QN90D mini-LED model is even brighter, topping out at around 2,000 nits.
There’s only so much more that OLED makers can do to increase brightness beyond current levels, and the display tech may have hit its peak in the latest generation of TVs. And while we’ve yet to measure the Bravia 9, mini-LED is capable of higher brightness than OLED tech, and that’s something Sony clearly had in mind when planning its new flagship. In the future, we can expect to see movies with even wider dynamic range, and mini-LED with its high peak brightness capability will be well-positioned to handle it.
Climate litigation is in the spotlight again after a landmark decision last week. The top European human-rights court deemed that the Swiss government was violating its citizens’ human rights through its lack of climate action. The case, brought by more than 2,000 older women, is one of more than 2,300 climate lawsuits that have been filed against companies and governments around the world (see ‘Climate cases soar’).
But does legal action relating to climate change make a difference to nations’ and corporations’ actions? Litigation is spurring on governments and companies to ramp up climate measures, say researchers.
‘Truly historic’: How science helped kids win a landmark climate trial
“There are a number of notable climate wins in court that have led to action by governments,” says Lucy Maxwell, a human-rights lawyer and co-director of the Climate Litigation Network, a non-profit organization in London.
Nature explores whether lawsuits are making a difference in the fight against global warming.
What have climate court cases achieved?
One pivotal case that spurred on change was brought against the Dutch government in 2013, by the Urgenda Foundation, an environmental group based in Zaandam, the Netherlands, along with some 900 Dutch citizens. The court ordered the government to reduce the country’s greenhouse-gas emissions by at least 25% by 2020, compared with 1990 levels, a target that the government met. As a result, in 2021, the government announced an investment of €6.8 billion (US$7.2 billion) toward climate measures. It also passed a law to phase out the use of coal-fired power by 2030 and, as pledged, closed a coal-production plant by 2020, says Maxwell.
Source: Grantham Research Institute/Sabin Center for Climate Change Law
In 2020, young environmental activists in Germany, backed by organizations such as Greenpeace, won a case arguing that the German government’s target of reducing greenhouse-gas emissions by 55% by 2030 compared with 1990 levels was insufficient to limit global temperature rise to “well below 2 ºC”, the goal of the 2015 Paris climate agreement. As a result, the government strengthened its emissions-reduction target to a 65% cut by 2030, and set a goal to reduce emissions by 88% by 2040. It also brought forwards a target to reach ‘climate neutrality’ — ensuring that greenhouse-gas emissions are equal to or less than the emissions absorbed from the atmosphere by natural processes — by 2045 instead of 2050. “In the Netherlands and Germany, action was taken immediately after court orders,” says Maxwell.
In its 2022 report, the Intergovernmental Panel on Climate Change acknowledged for the first time that climate litigation can cause an “increase in a country’s overall ambition to tackle climate change”.
“That was a big moment for climate litigation, because it did really show how it can impact states’ ambition,” says Maria Antonia Tigre, director of the Sabin Center for Climate Change Law at Columbia University in New York City.
What about cases that fail?
Cases that fail in court can be beneficial, says Joana Setzer at the Grantham Research Institute on Climate Change and the Environment at the London School of Economics and Political Science.
In a 2015 case called Juliana v. United States, a group of young people sued the US government for not doing enough to slow down climate change, which they said violated their constitutional right to life and liberty. “This is a case that has faced many legal hurdles, that didn’t result in the court mandating policy change. But it has raised public awareness of climate issues and helped other cases,” says Setzer.
One lawsuit that benefited from the Juliana case was won last year by young people in Montana, says Setzer. The court ruled that the state was violating the plaintiffs’ right to a “clean and healthful environment”, by permitting fossil-fuel development without considering its effects on the climate. The ruling means that the state must consider climate change when approving or renewing fossil-fuel projects.
What happens when people sue corporations?
In a working paper, Setzer and her colleagues found that climate litigation against corporations can dent the firms’ share prices. The researchers analysed 108 climate lawsuits filed between 2005 to 2021 against public US and European corporations. They found case filings and court judgments against big fossil-fuel firms, such as Shell and BP, saw immediate drops in the companies’ overall valuations and share prices. “We find that, especially after 2019, there is a more significant drop in share prices,” says Setzer. “This sends a strong message to investors, and to the companies themselves, that there is a reputational damage that can result from this litigation,” she says.
In an analysis of 120 climate cases, to be published on 17 April by the Grantham Research Institute, Setzer’s team found that climate litigation can curb greenwashing in companies’ advertisements — this includes making misleading statements about how climate-friendly certain products are, or disinformation about the effects of climate change. “With litigation being brought, companies are definitely communicating differently and being more cautious,” she says.
What’s coming next in climate litigation?
Maxwell thinks that people will bring more lawsuits that demand compensation from governments and companies for loss and damage caused by climate change. And more cases will be focused on climate adaptation — suing governments for not doing enough to prepare for and adjust to the effects of climate change, she says. In an ongoing case from 2015, Peruvian farmer Saúl Luciano Lliuya argued that RWE, Germany’s largest electricity producer, should contribute to the cost of protecting his hometown from floods caused by a melting glacier. He argued that planet-heating greenhouse gases emitted by RWE increase the risk of flooding.
More cases will be challenging an over-reliance by governments on carbon capture and storage (CCS) technologies — which remove carbon dioxide from the atmosphere and store it underground — in reaching emissions targets, says Maxwell. But CCS technologies have not yet proved to work at a large scale. For instance, in February, researchers criticized the European Union for relying too much on CCS in its plans to cut greenhouse-gas emissions by 90% by 2040 compared with 1990 levels.
“There is a tendency now for companies and governments to say, we’ll use carbon capture, we’ll find some technology,” says Setzer. “In the courts, we’ll start seeing to what extent you can count on the future technologies, to what extent you really have to start acting now.”
What about lower-income countries?
There will also be more climate cases filed in the global south, which generally receive less attention than those in the global north, says Antonia Tigre. “There is more funding now being channelled to the global south for bringing these types of cases,” she says. This month, India’s supreme court ruled that people have a fundamental right to be free from the negative effects of climate change.
Last week’s Swiss success demonstrates that people can hold polluters to account through lawsuits, say researchers. “Litigation allows stakeholders who often don’t get a seat at the table to be involved in pushing for further action,” says Antonia Tigre.
Maxwell thinks that the judgment will influence lawsuits worldwide. “It sends a very clear message to governments,” she says. “To comply with their human rights obligations, countries need to have science-based, rapid, ambitious climate action.”
Last September, Apple’s iPhone 15 Pro models debuted with a new customizable Action button, offering faster access to a handful of functions, as well as the ability to assign Shortcuts. Apple is poised to include the feature on all upcoming iPhone 16 models, so we asked iPhone 15 Pro users what their experience has been with the additional button so far.
The Action button replaces the switch that activates Ring and Silent on Apple’s iPhone 15 Pro models, while the standard iPhone 15 and iPhone 15 Plus models retain the traditional Ring/Silent switch. By default, the Action button still activates these two functions via a long press, but users can also make it activate a range of other functions, including quickly opening the camera app or enabling the flashlight, activating Voice Memos, Focus modes, Translate, and accessibility features like Magnifier.
Of around 7,000 MacRumors readers who responded to our poll on social media, just over half (50.6%) said they often forgot the Action button is even there, while over a quarter of respondents (26.8%) said they use the Action button “occasionally.” Based on readers who commented, most occasional users assigned the camera or flashlight to the Action button – functions that are also easily accessible via the Lock screen. A subsection of users in the same category said they have the Action button set to activate/deactivate Mute, to mimic the physical Mute switch it replaced.
Some respondents (12.6%) agreed with the description that the Action button is a “game changer.” Most users in this category used it to activate custom Shortcuts, which allowed for novel uses like skipping forward in podcasts, adding to-dos, prompting ChatGPT, activating smart lights, or opening a folder. Some in this category simply appreciated the fact that it saved them time accessing more standard functions that would otherwise involve navigating through onscreen menus.
The rest of our poll respondents (10%) agreed that the Action button was something of a “volume decoy,” implying that they often pressed it by accident when they intended to adjust audio levels via the volume buttons, usually when their iPhone was in a pocket or purse.
With the Action button introduced on the iPhone 15 Pro set to expand to all models later this year, we want to hear from current users: Does it make your iPhone life easier?
— MacRumors.com (@MacRumors) April 15, 2024
Our social media poll represents a small, self-selecting cohort of iPhone 15 Pro users. It is also an example of convenience sampling, and by no means statistically sound. Even so, it seems the case could be made that many people have had trouble finding a dedicated use case for the Action button.
Assigning the button to the camera appears to be the most popular way to increase the likelihood that it gets used. Launching the camera app like this avoids having to press or swipe the Lock Screen or select the Camera app from the Home screen. However, Apple is rumored to be adding a “Capture button” to the iPhone 16 for video recording, so the Action button might get less useful for those who use it for this purpose.
Meanwhile, anecdotal evidence suggests there is a fair amount of frustration among “power users” that Apple has not added more flexibility to the way the Action button works. Currently the button only responds to a long press, but more sophisticated iPhone users want a built-in ability to set different customizations for short presses, double-presses, and triple presses.
So what do you think of the Action button? Is it a hit or miss for Apple? Let us know your thoughts and any favorite use cases in the comments.
There’s a good reason why Hulu is one of the best streaming services out there, and it’s thanks to the wide range of movies and shows on there. But just as new movies and shows are set to arrive, Hulu are also preparing to remove another load of titles in April 2024.
Many of the movies leaving Hulu this month are releases from the 2020s, including dark comedy satire The Menu (2022) where Ralph Fiennes gives a gripping performance as an enigmatic restaurant chef. Ridley Scott’s multi-perspective epic The Last Duel (2021) will also come to the end of its course on Hulu, and its stellar ensemble cast (Matt Damon, Adam Driver, Jodie Comer) is not one to miss.
Some of these movies rank among the best Hulu movies, and some are leaving much sooner in the month than others, so make sure you don’t miss out on something great!
Everything leaving Hulu in April 2024
Leaving April 1
Savage Salvation (2022)
Leaving April 2
The Menu (2022)
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Leaving April 4
Monster Family 2: Nobody’s Perfect (2021)
Leaving April 5
Son of Bigfoot (2017)
Leaving April 6
Beast of Burden (2018)
Mr. Right (2015)
The Program (2015)
Leaving April 8
The War With Grandpa (2020)
Leaving April 14
Black Death (2010)
Drunk Stoned Brilliant Dead: The Story of the National Lampoon (2015)
Since the 1950s, scientists have had a pretty good idea of how muscles work. The protein at the centre of the action is myosin, a molecular motor that ratchets itself along rope-like strands of actin proteins — grasping, pulling, releasing and grasping again — to make muscle cells contract.
The basics were first explained in a pair of landmark papers in Nature1,2, and they have been confirmed and elaborated on by detailed molecular maps of myosin and its partners. Researchers think that myosin generates force by cocking back the long lever-like arm that is attached to the motor portion of the protein.
The only hitch is that scientists had never seen this fleeting pre-stroke state — until now.
In a preprint published in January3, researchers used a cutting-edge structural biology technique to record this moment, which lasts just milliseconds in living cells.
‘The entire protein universe’: AI predicts shape of nearly every known protein
“It’s one of the things in the textbook you sort of gloss over,” says Stephen Muench, a structural biologist at the University of Leeds, UK, who co-led the study. “These are experiments that people wanted to do 40 years ago, but they just never had the technology.”
That technology — called time-resolved cryo-electron microscopy (cryo-EM) — now has structural biologists thinking like cinematographers, turning still snapshots of life’s molecular machinery into motion pictures that reveal how it works.
Muench and his colleagues’ myosin movie isn’t feature-length; it consists of just two frames showing different stages of the molecular motion. Yet it confirmed a decades-old theory and settled debates over the order of the steps in myosin’s choreography. Other researchers are focusing their new-found director’s eye on understanding cell-signalling systems, including those underlying opioid overdoses, the gene-editing juggernaut CRISPR–Cas9 and other molecular machines that have been mostly studied with highly detailed, yet static structural maps.
Researchers have been able to capture images of individual myosin proteins as they pull on an actin filament during muscle contraction, confirming key details of the motion. First, myosin becomes cocked or primed, then it attaches to actin and its lever arm swings in a power stroke that slides the filament by about 34 nanometres.Credit: Sean McMillan
“The big picture is to move away, as much as possible, from this single, static snapshot,” says Georgios Skiniotis, a structural biologist at Stanford University in California, whose team used the technique to record the activation of a type of cell-signalling molecule called a G-protein-coupled receptor (GPCR)4. “I want the movie.”
Freeze frame
To underscore the power of cryo-EM, Skiniotis and others like to draw a comparison with one of the first motion pictures ever made. In the 1870s, photographer Eadweard Muybridge used high-speed photography technology, which was cutting edge at the time, to capture a series of still images of a galloping horse. They showed, for the first time, that all four of the animal’s hooves leave the ground at once — something that the human eye could not distinguish.
Similar insights, Skiniotis says, will come from applying the same idea to protein structures. “I want to get a dynamic picture.”
The ability to map proteins and other biomolecules down to the location of individual atoms has transformed biology, underpinning advances in gene editing, drug discovery and revolutionary artificial-intelligence tools such as AlphaFold, which can predict protein structures. But the mostly static images delivered by X-ray crystallography and cryo-EM, the two technologies responsible for the lion’s share of determined protein structures, belie the dynamic nature of life’s molecules.
“Biomolecules are not made up of rocks,” says Sonya Hanson, a computational biophysicist at the Flatiron Institute in New York City. They exist in water and are constantly in motion. “They’re more like jelly,” adds Muench.
The secret lives of cells — as never seen before
Biologists often say that “structure determines function”, but that’s not quite right, says Ulrich Lorenz, a molecular physicist at the Swiss Federal Institute of Technology in Lausanne (EPFL). The protein poses captured by most structural studies are energetically stable ‘equilibrium’ states that provide limited clues to the short-lived, unstable confirmations that are key to chemical reactions and other functions performed by molecular machines. “Structure allows you to infer function, but only incompletely and imperfectly, and you’re missing all of the details,” says Lorenz.
Cryo-EM is a great way to get at the details, but capturing these fleeting states requires careful preparation. Protein samples are pipetted onto a grid and then flash frozen with liquid ethane. They are then imaged using powerful electron beams that record snapshots of individual molecules (sophisticated software classifies and morphs these pictures into structural maps). The samples swim in water before being frozen, so any chemical reaction that can happen in a test tube can, in theory, be frozen in place on a cryo-EM grid — if researchers can catch it quickly enough.
That’s one of the first big challenges says Joachim Frank, a structural biologist at Columbia University in New York City who shared the 2017 Nobel Prize in Chemistry for his work on cryo-EM. “Even for very dexterous people, it takes a few seconds.” In that time, any chemical reactions — and the intermediate structures that mediate the reactions — might be long gone before freezing. “This is the gap we want to fill,” says Frank.
Caught in translation
Frank’s team has attempted to solve this problem using a microfluidic chip. The device quickly mixes two protein solutions, allows them to react for a specified time period and then delivers reaction droplets onto a cryo-EM grid that is instantly frozen.
This year, Frank’s team used their device to study a bacterial enzyme that rescues ribosomes, the cell’s protein-making factories, if they stall in response to antibiotics or other stresses. The enzyme, called HflX, helps to recycle stuck ribosomes by popping their two subunits apart.
Frank’s team captured three images of HflX bound to the ribosome, over a span of 140 milliseconds, which show how it splits the ribosome like someone carefully removing the shell from an oyster. The enzyme breaks a dozen or so molecular bridges that hold a ribosome’s two subunits together, one by one, until just two are left and the ribosome pops open5. “The most surprising thing to me is that it’s a very orderly process,” Frank says. “You would think the ribosome is being split and that’s it.”
Muench and his colleagues, including Charlie Scarff, a structural biologist at the University of Leeds, and Howard White, a kineticist at Eastern Virginia Medical School in Norfolk, Virginia also used a microfluidic chip to make their myosin movie by quickly mixing myosin and actin3.
‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures
But the molecular motor is so fast that, to slow things down ever further, they used a mutated version of myosin that operates about ten times slower than normal. This allowed the team to determine two structures, 110 milliseconds apart, that showed the swing of myosin’s lever-like arm. The structures also showed that a by-product of the chemical reaction that powers the motor — the breakdown of a cellular fuel called ATP — exits the protein’s active site before the lever swings and not after. “That is ending decades of conjecture,” says Scarff.
With this new model in mind, Scarff, whose specialty is myosin, and Muench are planning to use time-resolved cryo-EM to study how myosin dynamics are affected by certain drugs and mutations that are known to cause heart disease.
Microfluidic chips aren’t the only way researchers are putting time stamps on protein structures. A team led by Bridget Carragher, a structural biologist and the technical director at the Chan Zuckerberg Imaging Institute in Redwood City, California, developed a ‘spray and mix’ approach that involves shooting tiny volumes of reacting samples onto a grid before flash-freezing them6.
In another set-up — developed by structural physiologist Edward Twomey at Johns Hopkins University School of Medicine in Baltimore, Maryland, and his team — a flash of light triggers light-sensitive chemical reactions, which are stopped by flash-freezing7. Lorenz’s kit, meanwhile, takes already frozen samples and uses laser pulses to reanimate them for a few microseconds before they refreeze, all under the gaze of an electron microscope8.
‘Limitations everywhere’
The different approaches have their pros and cons. Carragher’s spray and mix approach uses minute sample volumes, which should be easy to obtain for most proteins; Twomey says his ‘open-source’ light-triggered device is relatively inexpensive and can be built for a few thousand dollars; and Lorenz says his laser-pulse system has the potential to record many more fleeting events than other time-resolved cryo-EM technologies — down to a tenth of a microsecond.
Revolutionary cryo-EM is taking over structural biology
But these techniques are not yet ready to be rolled out. Currently, there are no commercial suppliers of time-resolved cryo-EM technology, limiting its reach, says Rouslan Efremov, a structural biologist at the VIB-VUB Center for Structural Biology in Brussels. “All these things are fussy and hard to control and they haven’t really caught on,” adds Carragher.
Holger Stark, a structural biologist at the Max Planck Institute for Multidisciplinary Sciences in Göttingen, Germany, says that current forms of time-resolved cryo-EM might be useful for some molecular machines that operate on the basis of large-scale movements — for example, the ribosome. However, the technology is not ready for use on just any biological system. “You have to cherry pick your subject,” he says. “We have limitations everywhere.”
Despite the shortcomings, there are plenty of interesting questions for researchers to start addressing now using these techniques. Twomey is using time-resolved cryo-EM to study Cas9, the DNA-cutting enzyme behind CRISPR gene editing, and says the insights could help to make more efficient gene-editing systems.
Lorenz used his laser-melting method to show how a plant virus swells up after it infects a cell to release its genetic material7 (see ‘Viral blow-up’). He is now studying other viral entry molecules such as HIV’s envelope protein. “We have these static structures, but we don’t know how the system makes it from one state to the other, and how the machinery works,” he says.
Source: Ref.8
Skiniotis’s team is investigating GPCRs, including one called the β-adrenergic receptor, which has been implicated in asthma. Their work4 shows how activating the receptor triggers it to shed its partner G-protein, a key step in propagating signals in cells.
The researchers are now studying the same process in a GPCR called the µ-opioid receptor, which is activated by morphine and fentanyl among other drugs. In preliminary unpublished results, they have found that the dynamics of the receptor help to explain why some drugs such as fentanyl are so potent in promoting G-protein activation, while others aren’t. Such insights, says Skiniotis, are glimpses of unseen biology that molecular movies promise to reveal. Just don’t forget the popcorn.
This year, voters in five of the world’s biggest carbon-emitting territories go to the polls. These regions — the United States, India, Indonesia, Russia and the European Union — represent one-third of the world’s population and about the same proportion of human-made carbon emissions.
How the political wind blows from these elections will be crucial in determining whether humanity can correct its current trajectory of dangerous climate warming (see ‘Monstrous emissions’). Current climate policies are likely to result in warming of about 2.7 °C by 2100, according to the group Climate Action Tracker, which monitors global climate commitments — well above the 1.5 °C goal laid out in the 2015 Paris climate accord. Long-term climate commitments could prevent another 0.6 °C of warming, but those depend on further action by governments, including many whose leaders are up for election in 2024. It could be a pivotal year.
Source: Global Carbon Budget 2023 (emissions); UN Population Division (population)
United States: Biden versus Trump
In August 2022, US President Joe Biden surprised the world with a legislative victory on climate spending that, by some recent estimates, is likely to lock in nearly US$1 trillion in investment until 2032. This includes direct spending as well as tax credits for everything from wind and solar power to electric transport, carbon sequestration and reskilling programmes for people who currently work in the fossil-fuel sector. One of the Biden administration’s main jobs now is to ensure that the money is invested wisely and keeps flowing if Biden is re-elected on 5 November.
Researchers have estimated that Biden’s flagship achievement, the 2022 Inflation Reduction Act, could double the pace of US climate progress by itself and reduce the country’s carbon emissions by 43–48% by 2035, relative to 2005 levels. That is short of the US commitment to cut emissions by 50% by 2030, also compared with 2005, but the administration is pushing forwards on other fronts, including issuing regulations to reduce emissions from vehicles and power plants. Overall, climate specialists say it’s a historic effort that could help the world’s second-largest greenhouse-gas emitter (behind China) to lead a clean-energy revolution.
“We’ve never seen a decarbonization effort like this,” says Noah Kaufman, an economist at Columbia University’s Center on Global Energy Policy in Washington DC. The Biden administration’s climate agenda has significant momentum, Kaufman says, and another four years would help the administration to lock in progress. “The question is, what happens if we lose this momentum?”
How the biggest US energy bill ever could revive Biden’s climate agenda
Biden’s likely main opponent in the November election, former president Donald Trump, remains hostile to government action on climate, and there is little doubt that he will do everything he can to promote fossil fuels if he wins. He is widely expected to pull the United States out of the 2015 Paris climate agreement — for a second time. The first withdrawal, which came into effect on 4 November 2020, a day after Trump lost his re-election bid, was quickly reversed by the incoming Biden administration. Trump has also said he would use his executive authority to weaken climate regulations and expand federal oil and gas programmes.
But it would be difficult for Trump to override the clean-energy investments in the Inflation Reduction Act. Because those investments were laid out in a law, Congress would need to enact a new one to roll them back, says Samantha Gross, who heads the Energy Security and Climate Initiative at the Brookings Institution, a think tank based in Washington DC.
To have any chance of doing that, Republicans would need to retain control of the House of Representatives and win enough seats to take control of the Senate in the November elections. Even then, Gross says, it wouldn’t be easy. The law is already incentivizing businesses to invest and create jobs in communities across the country, and many are in Republican districts. “Once the economic benefits start flowing, the political calculus changes,” she says.
India: Modi’s climate balancing act
Climate change isn’t high on the agenda in India’s upcoming general elections. But it is crucial to Prime Minister Narendra Modi’s global ambitions, say researchers.
Voting across the vast country will probably take place in April and May. If Modi and his Bharatiya Janata Party (BJP) win a third five-year term, he will be preoccupied with his legacy as a climate leader, says Aseem Prakash, a political scientist at the University of Washington in Seattle.
India is the world’s third-biggest emitter of greenhouse gases. But the country is also home to 1.4 billion people, which is more than one-sixth of the world’s population. Its per-capita emissions are less than one-seventh those of the United States and one-quarter those of China.
In India’s upcoming election, climate action is not a campaign talking point for the two leading parties.Credit: Subhash Sharma/Polaris/eyevine
In 2021, at the COP26 global climate conference in Glasgow, UK, Modi committed to achieving net-zero emissions by 2070. India has also agreed that, with foreign financial and technical assistance, non-fossil-fuel sources will make up about half of its electricity generation capacity by 2030.
The country has backed some of those promises with action. India’s wind and solar power capacity has almost doubled over the past 5 years, to 135 gigawatts. Together with hydropower, renewables now account for 42% of power generation capacity (although owing to the variability of many of the sources, they make up a lesser share of actual electricity production). “It’s a renewables miracle,” says Sangeeth Selvaraju, a sustainable finance analyst at the Grantham Research Institute on Climate Change and the Environment in London.
Under a newly elected Modi, India’s climate policies will “continue in an aggressive manner”, says Suruchi Bhadwal, a climate scientist at The Energy and Resources Institute in New Delhi. These include expansion of solar and wind infrastructure, and investment in green hydrogen development. Last month, Modi’s government presented its interim budget for the year from April, which includes subsidies for offshore wind energy and rooftop solar panels — “two nascent industries that need a real boost”, says Selvaraju.
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But climate action is not a campaign talking point for the two leading parties, the BJP and the Indian National Congress, say researchers. Instead, the priority is energy security to meet burgeoning demand, which in the short term means more fossil-fuel consumption and a continued reliance on coal. Last year, energy demand peaked in September, and was 13% higher than during the previous year’s peak month of April. Coal still accounts for three-quarters of electricity generation — a reason why India has played a key part in resisting attempts to introduce language about phasing out fossil fuels in communiqués from the past few climate summits.
In September, India’s minister for power, Raj Kumar Singh, said the country might need to build new thermal power plants. “There will be more coal power plants in the next ten years,” says Nandini Das, a climate and energy economist at the policy institute Climate Analytics in Perth, Australia.
In the unlikely event that Modi loses, Selvaraju says he doesn’t expect a shift away from India’s dual push for renewables and coal, “simply because it’s not really in the hands of the politicians”. Unlike in the United States, India’s climate policies don’t flip-flop according to who is in power, says Dhruba Purkayastha, director for India at the non-profit research group Climate Policy Initiative, based in New Delhi.
But climate change should be on the agenda, says Das. From flooding to drought and heat stress, “India is a highly climate-vulnerable country.”
Indonesia: powered by nickel and coal
Indonesians went to the polls on 14 February to elect a new president and legislature. Votes are still being counted, but the majority of the almost 130 million Indonesians who voted look to have chosen a leader who promised continuity with the policies of Joko Widodo, the outgoing president. Prabowo Subianto, a former army general and minister of defence under Widodo, ran with Widodo’s eldest son, Gibran Rakabuming Raka, as his vice-presidential candidate.
“From the perspective of climate change, not much will change,” says Daniel Murdiyarso, a climate scientist and president of the Indonesian Academy of Sciences, who is based in Bogor, south of the capital Jakarta.
The result of Indonesia’s election is unlikely to affect its current climate policies, which reflect an economy that is heavily dependent on coal.Credit: Sulthony Hasanuddin/Antara Foto/Reuters
Researchers say that in the short term, that means more coal consumption and exports, slow progress on reducing deforestation and cheap but dirty nickel extraction. The country is the world’s leading producer of raw nickel, needed to fuel the growing global appetite for electric vehicles, batteries and stainless steel. “Business is probably going to trump any other concerns,” says political scientist Jemma Purdey at the Australia–Indonesia Centre at Monash University in Melbourne.
Even bigger business than nickel is coal. Indonesia is the world’s largest coal exporter, and 60% of its own electricity supply comes from the fossil fuel — a reliance that is locked in for several more decades owing to government support and relatively young power plants. Together with the difficulty of building an electricity grid across Indonesia’s many islands, this is why renewables have not boomed in the country as they have in India or China. “It’s got the resources, and it’s got the conditions to generate a lot of wind and solar power. But the infrastructure and institutional challenges are yet to be tackled for that to happen at scale,” says Selvaraju.
Indonesia aims to reach net-zero emissions by 2060, “but has been fairly non-committal” with that target, says Dirk Tomsa, a political scientist at LaTrobe University in Melbourne. Despite a relatively young voting population, climate and environment were not key issues in these elections, says Ika Idris, who chairs the Monash Climate Change Communication Research Hub Indonesia Node, and is based in Jakarta. “During the campaign, none of the candidates really focused on that.”
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Some popular initiatives that Subianto is likely to inherit include support for the development of a home-grown electric vehicle industry, as well as construction of a renewables-fuelled green city, Nusantara, which is set to become Indonesia’s new capital later this year. But even these were framed as economic development and not climate issues, says Idris.
In 2020, Widodo banned exports of raw nickel to strengthen domestic processing, which is highly carbon-intensive. Subianto’s win will probably see continued prioritization of nickel mining and processing to fuel the country’s economic development, at the cost of concerns about local environmental pollution and worker safety, say researchers.
Indonesia is also home to some of the world’s largest tropical rainforests, peatlands and mangroves. Under Subianto, researchers expect Indonesia to adhere to its international commitments to reducing deforestation — the rate of forest loss there has declined over the past five years — while also strengthening the palm-oil industry, which adds to pressure on rainforests and carbon-storing peatlands.
Russia: the smog of war
In March, Russian leader Vladimir Putin will begin a fifth term as president following an election, the result of which is not in doubt. Climate change will not feature in a campaign that Putin will use to claim endorsement of Russia’s invasion of Ukraine and rally anti-Western sentiment.
The ongoing war and economic sanctions — imposed by the European Union and countries including the United States and United Kingdom — are likely to hinder future climate action in the world’s fourth-largest greenhouse-gas emitter, says Marianna Poberezhskaya, who studies Russian climate politics at Nottingham Trent University, UK.
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“Major shocks like economic crises, and obviously the war, the worst of them all, makes the already quite weak climate position and policy in Russia even weaker,” says Poberezhskaya. This is despite the nation already experiencing severe wildfires and flooding owing to climate change in recent years.
Russia is aiming to cut greenhouse-gas emissions by 70% compared with 1990 levels by 2030, and to reach carbon neutrality by 2060. The nation’s emissions are already around 30% below 1990 levels, with most of this reduction due to deindustrialization following the collapse of the Soviet Union in 1991. According to Putin’s regime, these goals will be met through the expansion of forest carbon sinks, carbon capture and storage technologies and a continued reliance on nuclear power and hydropower.
The plan to cut emissions does not include a phase-out of fossil fuels, on which the Russian economy is highly dependent. “Russia is not itself going to reduce its fossil-fuel economy. If it goes down, it is because of other countries’ policies — Russia will clearly sell fossil fuel as long as someone buys it,” says Anna Korppoo, who studies Russian climate policy at the Fridtjof Nansen Institute in Fornebu, Norway. Proposed targets to expand tree-based carbon sinks are unlikely to be met, she says: these sinks are currently in decline and there are no national policies to reverse the trend.
The detrimental impact of Russia’s war in Ukraine on Arctic climate science will also continue. Russia covers almost half the landmass of the Arctic, but in March 2022, immediately after the invasion, the seven other countries on the Arctic Council, which discusses sustainable development and environmental issues in the polar region, suspended cooperation with Russia. Russian data have been excluded from Arctic climate models and from research on the impacts of climate change on Arctic people and ecosystems, and Russia last month froze payments to the Arctic Council. “The loss of Siberian research stations may be detrimental to our ability to track global responses to climate change,” says Arctic ecosystem modeller Efrén López-Blanco at Aarhus University in Denmark.
As the war continues, climate change and its impact on human rights will continue to take a back seat, says Matthew Druckenmiller, vice-president of the International Arctic Science Committee. “This is sad to see; the majority of Indigenous peoples in the Arctic are in Russia, and now they are removed from the equation.”
EU: A challenging shift to the right
The European Union likes to see itself as a world leader on climate action. In 2021, the bloc’s members agreed and passed laws to reduce net greenhouse-gas emissions by at least 55% from 1990 levels by 2030, and to achieve climate neutrality by 2050. A proposal unveiled last month targets an even more ambitious 90% reduction by 2040. So far, Europe has reduced its emissions by 32.5% from 1990 levels.
Over 4 days from 6 to 9 June, European citizens from 27 countries will elect 720 politicians to the European Parliament for 5 years. Polling indicates a sharp move towards parties on the right that are less focused on climate action, a trend that could stymie Europe’s climate leadership and delay urgent measures, say experts.
Climate “is not a big issue for most far-right parties and it’s not a priority”, says Claire Dupont, a climate policy specialist at Ghent University in Belgium. They tend to focus on more nationalistic interests, she says. Polls indicate that the main parliamentary groupings — the centre-right European People’s Party and the centre-left Progressive Alliance of Socialists and Democrats — will maintain their majority in the parliament, which scrutinizes other EU bodies and has the power to adopt and amend proposed legislation.
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This election is only the beginning of the EU’s political process. The parliament ultimately elects the president of the European Commission, which sets out the EU’s strategy for the next five years and monitors policy implementation, says Dupont. The current president, Ursula von der Leyen, put the European Green Deal and its climate targets at the heart of the bloc’s strategy, and in February announced that she would seek a second term.
But bottom-up political pressures mean that Europe’s previous broad consensus on climate action is beginning to fray. “There’s not a lot of room to roll back decisions on climate,” says Corinne Le Quéré, a climate scientist at the University of East Anglia in Norwich, UK. “But there is room to slow down progress or to give political flavours to actions that are going to be in place.” This has international ramifications, she warns. “It is the region that is the most proactive about tackling climate change, so if the leaders start slowing down on climate action, then the risk is that this is going to slip all around the world.”
In particular, the EU’s nature-based climate goals, including biodiversity and soil protections, are running into trouble. Last month, the bloc shelved plans to cut pesticide use and diluted its green farming provisions after protests by farmers in several member states. The EU’s total carbon emissions have gone down, but emissions from its agricultural sector have declined only modestly in the past decade.
Another sticking point is carbon capture and storage technologies, which the EU will have to rely on if it is going to meet its most ambitious emissions targets. Right-leaning parties tend to favour these technological solutions over those that require behavioural change, but they have not been shown to work at scale. “The other carbon capture techniques of planting forests, upgrading our soils and nature-based solutions are already facing a lot of backlash,” says Dupont.
“The EU has successfully tackled the low-hanging fruit, like renewable energy and energy efficiency,” she says. “Can it actually go the next step in tackling the harder parts of the transition to carbon neutrality?”
Midnight is a film adaptation of a classic by the Father of Manga. Photo: Apple
Osamu Tezuka’s Midnight manga gets adapted to live action in the latest “Shot on iPhone” project. It’s an action film about a mysterious late-night taxi driver.
Apple also released a “making of” video to show how the movie was produced with an iPhone 15 Pro.
Osamu Tezuka’s Midnight adapted in ‘Shot on iPhone’ film
The capabilities of iPhone cameras have increased dramatically over the years, and have become a strong selling point for the devices. To demonstrate their potential, Apple periodically releases a “Shot on iPhone” film.
The latest entry is Midnight, an adaptation of a manga that Tezuka released in 1986.
Apple’s official description says:
“Director Takashi Miike brings to life Midnight, a manga by Osamu Tezuka. All shot on iPhone 15 Pro. A mysterious taxi driver lends a hand to Kaede, a young girl chased by assassins.”
Osamu Tezuka has been called the Father of Manga, and some people consider him the Japanese equivalent of Walt Disney as he also made animated series and films. He’s credited with taking manga mainstream, first with children’s stories and later with offerings for adults.
Behind the scenes
The point of any “Shot on iPhone” film is to show off the capabilities of Apple’s handsets, and that requires a “making of” film. Of course there’s one for Midnight.
It includes commentary by director Takashi Miike, who is no stranger to action films.
Apple has taken a significant leap by introducing a new sports app that aims to redefine how sports enthusiasts engage with their favorite games. This innovative app is designed to cater to the needs of sports fans by providing real-time information, scores, and updates across a variety of sports teams and leagues. If you’re a sports fan looking for a convenient way to stay updated, you’ll be pleased to know that Apple’s latest offering could be exactly what you need, the video below from Zollotech gives us a run-through of the new Apple Sports App.
First and foremost, it’s essential to note that the Apple Sports app is exclusively available on the iPhone and requires iOS 17.2 or later. This initial rollout has been geographically limited to users in the United States, the UK, and Canada. While the reasons behind this selective availability remain unclear, it’s an important consideration for potential users outside these regions. At this stage, the app does not support iPad, Mac, or Vision Pro, narrowing its accessibility to iPhone users only.
Upon diving into the app, you’ll find that it allows users to personalize their experience by selecting their preferred leagues or teams. The app covers an impressive range of sports, including Major League Baseball (MLB), Major League Soccer (MLS), men’s college basketball, the National Basketball Association (NBA), and the National Hockey League (NHL). Although it currently lacks coverage for the National Football League (NFL) and Formula 1 (F1), Apple has assured that these will be included in future updates.
The real-time updates feature stands out, offering play-by-play breakdowns, team stats, and even betting odds. For users who prefer not to engage with betting, the app provides an option to hide this information, showcasing Apple’s consideration for user preferences.
One of the most intriguing aspects of the Apple Sports app is its design, which seems to offer a glimpse into the possible direction of iOS 18’s design philosophy. However, the app’s current version lacks intuitive gestures for navigation, such as swiping between sections. This design choice feels somewhat out of step with Apple’s renowned emphasis on user-friendly interfaces, suggesting there’s room for improvement in future versions.
Apple’s commitment to expanding the app’s sports coverage and enhancing its functionality is evident. The inclusion of NFL and F1 in the near future is a promising development for fans of these sports. Although the app is still in the early stages of its lifecycle, characterized by a minimalist design and limited features, it demonstrates significant potential for becoming a valuable resource for sports fans.
Apple’s new sports app is not just another addition to its suite of applications; it’s a testament to the company’s ongoing efforts to enhance user experiences. While it currently has its limitations in terms of scope, availability, and intuitive navigation, the app’s foundation is solid. Its focus on providing real-time sports updates in a user-friendly manner sets the stage for what could become an indispensable tool for sports enthusiasts around the globe. As Apple continues to refine the app and expand its features, users can look forward to an even more engaging and comprehensive sports viewing experience.
Source & Image Credit: Zollotech
Filed Under: Apple, Apple iPhone, Top News
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In the rapidly evolving world of digital assistants, Google has taken a significant leap forward with the introduction of Gemini, a sophisticated platform designed to elevate the user experience to new heights. This article delves into the essence of Google Gemini, previously known to many as Google Assistant with Bard, showcasing its integration capabilities, installation nuances, and a plethora of functionalities that span both personal and professional domains. If you’re keen on discovering how Gemini can transform your interaction with technology watch the video below from In Depth Tech Reviews.
Getting to Know Gemini
At its core, Google Gemini is an advanced digital assistant tailored for both Android and iOS users, with a special focus on Android devices in this context. The platform has been engineered to seamlessly integrate with your device, providing a comprehensive guide for installation outside the U.S., where it first made its mark. For Android enthusiasts, getting Gemini up and running involves downloading an APK from APK Mirror, ensuring that your device runs on Android 12 or later and is equipped with at least 4GB of RAM.
Installation and Compatibility
You will be pleased to know that the installation process is straightforward, especially for Android users. Gemini stands out by replacing the traditional Google Assistant on Pixel phones, introducing a suite of innovative features that include voice and keyboard inputs, the ability to attach photos to commands, and a unique feature for attaching screenshots within apps to address specific queries.
Exploring Gemini’s Capabilities
Gemini’s functional overview is nothing short of impressive. Here’s what you can expect:
Travel Assistance: Planning your next trip? Gemini offers detailed information on flights, hotels, and activities, enhancing your travel experience with options for feedback, information validation, and sharing.
Creative Photo Generation: Whether for presentations or creative endeavors, Gemini’s image generation capabilities are designed to spark your imagination.
Email and Work Management: Streamline your email tasks with Gemini’s efficient categorization and summarization features, including the ability to create templates for cover letters or compose emails from scratch.
Information at Your Fingertips: From identifying locations in photos to summarizing web articles and generating code snippets, Gemini is your go-to for queries across a broad spectrum.
Basic Assistant Functions: Gemini doesn’t skimp on the basics either, performing all the traditional Google Assistant tasks like setting timers, managing smart devices, and navigation with ease.
Understanding Its Limitations
While Gemini represents a significant advancement in digital assistant technology, it’s important to acknowledge some of its limitations. These include the absence of continued conversation support, challenges in identifying clothing in images, and occasional inaccuracies in product identification compared to Google Lens. However, these minor setbacks do not overshadow the immense value Gemini brings to the table.
Gemini’s integration into Android and iOS platforms, coupled with its customizable features and ability to share information, make it an indispensable tool for both personal and professional use. The video guide provides a comprehensive overview of Gemini’s capabilities, setup process, and practical applications, showcasing its potential to enhance productivity and simplify a wide range of tasks.
Whether you’re looking to manage your emails more efficiently, need assistance with your travel plans, or are in search of a creative spark for your next project, Google Gemini offers a well-rounded suite of features to meet your needs. Its advanced functionalities and seamless integration with Android devices underscore Google’s commitment to enhancing user experience through innovation.
As technology continues to advance, tools like Gemini are pivotal in shaping the future of digital interaction. By embracing these advancements, users can unlock a new realm of possibilities, making everyday tasks more manageable and exploring new horizons with ease.
Source & Image Credit: In Depth Tech Reviews.
Filed Under: Guides
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