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NASA admits plan to bring Mars rocks to Earth won’t work — and seeks fresh ideas

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This animation shows NASA's Perseverance Mars rover collecting a sample from a rock using a coring bit on the end of its robotic arm.

NASA’s Perseverance rover collects a sample from a Martian rock using a bit on the end of its robotic arm.Credit: NASA/JPL-Caltech

NASA announced today that it is abandoning its longstanding plan for ferrying rock and soil samples from Mars to Earth. Instead the agency will seek proposals for quicker and cheaper ways to deliver the samples to Earth.

An independent review board concluded last year that NASA’s Mars sample return mission could cost as much as US$11 billion, more than what it cost to launch the James Webb Space Telescope. In a report released today, a separate NASA review team concluded that even if the agency spent that much money, the dropoff of the samples on Earth would be delayed until 2040. The agency had originally sought to land the samples on Earth in the early 2030s.

The $11 billion price tag is “too expensive,” said NASA administrator Bill Nelson at a press briefing, and “not returning the samples until 2040 is unacceptable.” Nelson said the agency “is committed to bringing at least some of the samples back” and later said NASA would return “more than 30” of the 43 planned samples.

Scaling back

NASA’s Perseverance rover has already collected more than 20 rock samples from Jezero Crater, where the rover landed in 2020. Scientists think that the crater was once filled with a lake of water, and samples from the crater and its surroundings could provide a window into the planet’s history and, perhaps, evidence of past life on the red planet.

In the agency’s original vision, a NASA spacecraft would have flown to Mars carrying a two-part retrieval system: a half-ton lander — which would have been the most massive vehicle to ever land on Mars — and a rocket to fly the lander and samples into Martian orbit. There they were to meet a spacecraft launched by the European Space Agency that would fly the samples to Earth.

Now NASA plans to solicit proposals — from companies as well as NASA centres — for a streamlined system, perhaps one that uses a lighter lander, Nicky Fox, the associate administrator for NASA’s Science Mission Directorate, said at the briefing. The deadline for proposals is 17 May, and the revised mission will be chosen later this year. Fox did not respond directly to reporters’ questions about when the samples will reach Earth under the new scheme.

NASA recommends spending $200 million of its planetary-science budget in 2025 on assessing alternative architectures for Mars sample return, Fox said. Dedicating any more money to the mission threatened to “cannibalize” other planetary science missions, Nelson said.

Back to the drawing board

Vicky Hamilton, a planetary scientist at the Southwest Research Institute in Boulder, Colorado, expressed disappointment that eight months after the independent review board released its report, the agency still lacks a solid plan for “a very valuable science goal.”

Returning these samples would also demonstrate capability for two-way trip to Mars before we can send astronauts, says Bethany Ehlmann, a planetary scientist at the California Institute of Technology in Pasadena, California. “The sample return technology is here, it exists,” she says. “It’s a matter of putting the pieces together.”

But scientists were relieved by one announcement: Fox said the revised timeline for sample return will not affect the science goals for Perseverance, including plans for it to explore terrain beyond Jezero Crater.

Among samples collected outside the crater will be “some of the ancient crust of Mars, representing rocks older than we have seen yet in Jezero Crater, some of which may have been altered by near-surface water,” says Meenakshi Wadhwa, a planetary scientist at Arizona State University in Tempe and principal scientist for the Mars Sample Return program.

So far, the only Mars samples that scientists have been able to study on Earth are bits and pieces ejected from the red planet that made it to Earth as meteorites. All known Martian meteorites are “igneous” rocks, meaning that they solidified from lava, and all are very old. As a result, they provide valuable timestamps for Mars’ geological evolution, but carry little information about how the planet’s surface was shaped by the water that once flowed across it.

To achieve the mission’s main goal of searching for signs of past life, the real treasures are layered sedimentary rocks formed by minerals and organic matter deposited over the aeons by water. Perseverance’s instruments have already detected organic molecules in Martian samples, but whether those molecules are a marker of past life can only be determined by closer scrutiny in laboratories on Earth.

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Apple’s Work on Robots: What We Know So Far

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With the Apple Car canceled, Apple is exploring new markets where it might be able to find new revenue streams, and personal robotics is apparently one area the company is investigating.

roseytherobot
This guide highlights everything we know about Apple’s interest in robotics, and we’ll update it with new rumors going forward.

The Robot Rumors

According to Bloomberg‘s Mark Gurman, Apple is looking for its “next big thing,” and robotics are one area of focus. Apple has engineering teams working on various in-home robotic devices and the AI software and functionality that might be able to make a home robot useful.

Apple’s work on robotics takes place in the hardware engineering division and in its AI and machine learning group under AI chief John Giannandrea.

Mobile Robot

Apple is considering a mobile robot that would follow users around the home, presumably serving as something like an iPad on wheels. A robot would likely be able to place FaceTime calls, monitor the home and the people in it, carry out simple tasks, and answer queries.

Apple is said to be exploring AI algorithms that would be used to help robots navigate cluttered spaces in homes, and while Apple wants to design a robot that would clean and do chores much like Rosey in the Jetsons, it’s too complicated for now. Gurman says that such a robot is unlikely this decade due to “extraordinarily difficult engineering challenges.”

Table-Top Robot

Another Apple project is described as an “advanced table-top home device” where robotics are used to move a display around. The device, which is described as a robotic motor on a small stand, would mimic the head movements of a person on a ‌FaceTime‌ video call. It would be able to nod, or precisely lock on to a single person during a group ‌FaceTime‌ call. Gurman says that Apple has had some difficulty with weight and balance, and Apple is also not sure that consumers will pay “top dollar” for such a product.

The robotic display is said to be further along than Apple’s mobile robot, but it has been “added and removed from the company’s product roadmap” several times over the years.

Secret House Facility

Apple reportedly has a secret facility that is designed to look like the inside of a home, and that’s where it is testing future home products.

Other Home Devices

There are some more realistic products that are in the works, with rumors suggesting that Apple is developing an iPad-like home hub device that would serve as a central way to control smart devices. Apple has also been rumored to be working on a version of the Apple TV that integrates HomePod speakers and a camera, and there have been rumors of a ‌HomePod‌ with a display.

Apple’s Competition

Amazon has a $1,600 “Astro” robot that it sells by invitation. Astro is able to navigate the home and remotely check specific rooms, people, and things when the user is away from home.

Amazon AstroAmazon Astro
The robot is able to send an alert if an unrecognized person is detected, or if there are sounds like an alarm. Astro has a built-in display and can be used for watching TV, placing calls, setting reminders, sending messages, and more. Astro uses Alexa, and Amazon suggests that it can be used to “remotely care for aging loved ones.”

Astro is also able to carry “a variety of accessories” such as a Ziploc container, a blood pressure monitor, and a Furbo Dog Camera that provides treats for a pet.

Sony has experimented with robots, and is best known for the Aibo robotic dog. Priced at $2900, Aibo is designed to act like a real dog with dynamic movements, lifelike expressions, curiosity, and an interest in human interaction. Aibo is able to learn tricks, play with toys, and listen to commands.

There are a number of other home robots on the market, but the best known may be the wide range of robot vacuums like the Roomba that are able to navigate the home to automatically clean up dust, dirt, pet fur, and other debris.

Robot Launch Date

Apple’s work on personal robotics is in the early stages, and the company has small teams that are exploring different concepts. It is not clear if some kind of robot will ever launch, and there is no word on when if so.

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California wants to introduce a law that will force workers to disconnect from work

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In an attempt to help citizens across the state have some respite from the pressures of work, California State Assembly member Matt Haney has introduced AB 2751, a proposition designed to give workers the “right to disconnect” from work-related communications outside of working hours.

AB 2751 draws inspiration from similar legislation in countries like France, Spain, and Ireland. If passed, it would set a precedent for not only the US but other countries globally. In recent months, all eyes have been on California’s tech sector over concerns that Silicon Valley’s work-life balance has degraded.

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Google Home app could soon work offline and finally support your old Nest camera

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In a recent Reddit AMA, Google revealed it’s working on multiple projects for its smart home platform. Chief among these is the introduction of an offline mode. The way Google Home currently works, as explained by Android Authority, is commands sent to a device are transmitted through company servers first before affecting your network. If your internet ever goes out, commands cannot be sent at all which can be frustrating for homeowners. Offline mode will directly address this by enabling local control.

It may, however, be a while until we see the feature rollout. One of the Google devs told a commenter that the team is focusing more on routing device interaction locally through the Matter standard. They’re doing this first because they want to establish a stable software foundation with low latency before moving forward. “Once…. a significant portion of your traffic [is] running locally,” the company will look into establishing an offline mode for Google Home.  

Bringing in the old

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we must work together to prepare better

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When Hurricane Otis hit Acapulco on the Pacific coast of Mexico on 25 October 2023, it had developed much more quickly and taken a different course than predicted. It damaged an area covering nearly 700 hectares, home to around 560,000 people (see go.nature.com/499dwgy). A preliminary assessment suggests that reconstruction could cost between US$14 billion and $21 billion (see go.nature.com/3pkbvav).

The hurricane’s impact exposed a lack of readiness from the Mexican government’s National Civil Protection System, local authorities, emergency response agencies and the private sector (particularly the tourism industry); this lack of preparedness affected a large part of the local population.

It also laid bare the structural and socio-economic vulnerabilities that prevail in the country. Years of uneven development and territorial planning have led to the formation of settlements that are particularly at risk from natural hazards and in which the poorest communities are systematically the most vulnerable. As extreme weather events increase in frequency and intensity, so does the need for communities to be better prepared — and better repaired.

In 2023, we and others founded the Mexican Network of Scientists for Climate (REDCiC, for its acronym in Spanish) to build bridges between those working on climate issues from different perspectives. This includes scientists and postgraduate students from the country at Mexican and international public and private research institutions, as well as journalists and outreach professionals. The network currently comprises around 100 members, and is likely to double in size in a couple of years. By organizing activities such as conferences and workshops, REDCiC facilitates scientific exchange and knowledge sharing, and seeks to ensure that climate adaptation and mitigation policies are rooted in robust data and analyses. For example, a workshop on Hurricane Otis led to a collaboration with the Mexican federal government’s National Council of Humanities, Sciences and Technologies (Conahcyt). And through public campaigns, media exposure, outreach and education, REDCiC engages the public in climate actions and highlights the role of citizen science, local practices and Indigenous Knowledge in addressing current and future environmental challenges.

Grounded in this interdisciplinary perspective, here we set out three priorities for scientists and policymakers to tackle climate-driven hazards and help reduce vulnerability.

Invest in modelling and forecasting

Disasters fuelled by the climate crisis are on the rise globally. In 2023 alone, record-breaking floods hit multiple countries, including the United States (see go.nature.com/3psmtaj), India and several Mediterranean nations. According to the international disaster database EM-DAT, there were prominent episodes of intense droughts (go.nature.com/496q8uj), heatwaves1 and wildfires2 across the Northern Hemisphere, including in Canada, the United States and Mexico. It is essential that models and practices reflect current climate trends as accurately as possible.

A NOAA satellite image showing Hurricane Otis at night

A satellite image of the category 5 Hurricane Otis over the west coast of Mexico.Credit: GOES-East/NOAA/Alamy

Why did state-of-the-art models fail to forecast that Otis would reach the maximum intensity (a category 5 hurricane), rather than remain a tropical storm? Thorough analyses are required, but it seems to have stemmed partly from its rapid development in the East Pacific region, where data-collection points are sparse. The limited availability of ocean buoys, land observations, radars and hurricane hunters along the west coast of Mexico places heavy reliance on satellite imagery for forecasting, which, along with the aggravating nature of climate impacts, can lead to less-accurate forecasts.

Governments and funding agencies must invest in better infrastructure and instrumentation, along with more research into weather events. Many phenomena — including how hurricanes intensify3 — are complex and not well understood. They remain difficult to predict despite considerable advances in meteorological modelling and forecasting in recent decades4.

An overhaul of what is considered expertise is also required — Indigenous Knowledge and local and traditional practices have typically been dismissed, but can help to improve information quality and data availability for modelling and forecasting5. This is especially crucial for a country such as Mexico, where a large proportion of lands (including at least 60% of forests and tropical rainforests) are managed by Indigenous and local communities.

Build resilience in vulnerable communities

The effects of Hurricane Otis also underscore the need to improve early-warning systems — which is itself contingent on accurate forecasts. Because disaster preparation becomes difficult once winds reach tropical storm force (sustained surface winds of 63–117 kilometres per hour), alerts should be issued between 36 and 48 hours before the predicted impact. This is in line with the United Nations’ Early Warnings for All initiative, which aims to ensure everyone is protected from natural hazards by 2027.

To protect populations effectively, communication must be rapid and seamless between stages, from data collection and forecasting to the spread of disaster-risk knowledge and warnings to communities that are likely to be affected.

Moreover, the response capacity of a community comes into play. This aspect is relatively subjective and, in a sense, is not just a policy issue but a political one, because it involves defining what is meaningful, desirable and a priority. Power dynamics at local and national levels have long led to the marginalization of Indigenous Peoples and local communities, which means that such groups have historically been excluded from decision-making processes.

A view of someone's lower body walking through a mangrove restoration nursery

Mangrove saplings planted by a community reforestation project in El Delgadito, Mexico.Credit: Gemina Garland-Lewis

In making landfall in and around Acapulco, Otis hit an area known for its long-standing stark inequalities and vulnerabilities, and its lack of inclusive mechanisms for planning, coordinating and implementing risk strategies. Farther inland, the government of Mexico City has announced the development of ‘community brigades’ to address these issues. Groups of trained volunteers help to lead disaster-risk prevention and responses in their communities, although the project is still in the developmental phase.

As well as being disproportionately affected by the effects of climate change, low- and middle-income countries often encounter significant barriers to implementing long-term climate strategies. Although international climate justice and loss-and-damage mechanisms are crucial, so are ambitious national and regional actions. A robust adaptation framework involves reshaping urban and rural development strategies, re-evaluating building codes and construction practices for efficiency, circularity and resilience, and reconceptualizing reconstruction efforts to incorporate ecosystemic, social and cultural diversity. This can succeed only if the framework is put in place by local and national governments working with local communities, because it is not enough to just swiftly and pragmatically disburse loss-and-damage funding. Local needs, challenges and priorities need to be considered.

Historically, low- and middle-income countries have been assigned the role of resource providers. These prevailing dynamics of global production, consumption and trade must be re-evaluated. Each country must assess the extent to which it can decouple resource extraction from economic growth, by reducing reliance on linear models of production and consumption, and improving resource efficiency and circularity. Similarly, nations must explore strategies to decouple economic growth from overall prosperity and quality of life. This includes a re-evaluation of the significance of private, public and social property, which can play a key part in resource demand. For example, prioritizing investments in public infrastructure and urban utilities can alleviate resource demand. Rather than promoting private amenities such as swimming pools, which are often an inefficient use of land and resources, emphasis should be placed on public alternatives such as open spaces and public recreational areas.

Work with local communities

In Mexico, investing in and implementing mid- and long-term adaptation policies and plans has proved challenging, even though these have been formulated by the federal government, most of the state governments and a few municipal governments. This is largely because more than one-third of the country’s population lives in poverty, according to CONEVAL (the National Council for the Evaluation of Social Development Policy). Against this background, addressing basic urgent needs within a framework of short-term goals has necessarily been prioritized over future climate adaptation plans, even though this population group is likely to be most affected by long-term climate effects.

Beyond poverty and inadequate basic services and infrastructure, however, climate action is hindered by weak governance, restricted funding, limited human capacity at the local level and a lack of trust and involvement of Indigenous and local communities.

Tools such as risk atlases, territorial and hydrological planning and building standards must be adapted and robustly updated to take climate risks and systemic vulnerabilities into account. For this to happen, it is essential for the scientific community, practitioners, government agencies and, certainly, Indigenous and local communities to reach a consensus on the most suitable criteria, while considering diversity (spatial, social and cultural). A participatory and inclusive consensus should enable development of meaningful metrics to assess vulnerability and evaluate the effectiveness of actions taken.

This type of consensus-building practice led to the successful reforestation of mangroves in the El Vizcaíno Biosphere Reserve in Mexico. The mangroves protect the local coastal community of El Delgadito from hurricanes, storms and floods; provide habitats for fish and shellfish — a key source of livelihood — and serve as carbon dioxide sinks. Since 2017, however, it has been recorded that mangroves have suffered dryness and uprooting, which is attributed to climate change.

In response, in 2019, the local community initiated a reforestation effort in partnership with scientists at Mexican institutions, the US–Mexican non-governmental organization WILDCOAST and the Mexican government’s National Commission of Natural Protected Areas (CONANP). This enabled the reintroduction of more than 60,000 plants in 4 years6. Women and young people of any gender are actively involved in planting, maintenance and monitoring activities. Children are also encouraged to participate, fostering environmental awareness and education in the community.

The REDCiC network aims to promote progress along all three priorities outlined. It fosters interactions in the scientific community — from climate, environmental and social sciences to public health; supports communication between scientists, relevant institutions and the public; and promotes the inclusion of Indigenous and local communities at all levels of the discourse.

These collaborations are crucial for building a climate-resilient society, particularly in contexts that are characterized by constrained capacities and escalating needs, as in Mexico. International organizations, local and regional governments, scientific institutions, organized civil society, the private sector and the media should support networks such as this one — in Mexico and elsewhere — through funding but also by engaging with their members and activities to accelerate transformational, rather than merely incremental, climate action.

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How Uber and the gig economy changed the way we live and work

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Gig work predates the internet. Besides traditional forms of self-employment, like plumbing, offers for ad-hoc services have long been found in the Yellow Pages and newspaper classified ads, and later Craigslist and Backpage which supplanted them. Low-cost broadband internet allowed for the proliferation of computer-based gig platforms like Mechanical Turk, Fiverr and Elance, which offered just about anyone some extra pocket change. But once smartphones took off, everywhere could be an office, and everything could be a gig — and thus the gig economy was born.

Maybe it was a confluence of technological advancement and broad financial anxiety from the 2008 recession, but prospects were bad, people needed money and many had no freedom to be picky about how. This was the same era in which the phrase “the sharing economy” proliferated — at once sold as an antidote to overconsumption, but that freedom from ownership belied the more worrying commoditization of any skill or asset. Of all the companies to take advantage of this climate, none went further or have held on harder than Uber.

Uber became infamous for railroading its way into new markets without getting approval from regulators. It cemented its reputation as a corporate ne’er-do-well through a byzantine scandal to avoid regulatory scrutiny, several smaller ones over user privacy and minimally-beneficial surcharges as well as, in its infancy, an internal reputation for sexual harassment and discrimination. Early on, the company used its deep reserves of venture capital to subsidize its own rides, eating away at the traditional cab industry in a given market, only to eventually increase prices and try to minimize driver pay once it reached a dominant position. Those same reserves were spent aggressively recruiting drivers with signup bonuses and convincing them they could be their own boss.

Self-employment has a whiff of something liberatory, but Uber effectively turned a traditionally employee-based industry into one that was contractor-based. This meant that one of the first casualties of the ride-sharing boom were taxi medallions. For decades, cab drivers in many locales effectively saw these licenses as retirement plans, as they’d be able to sell them on to newcomers when it was time to hang up their flat cap. But in large part due to the influx of ride-sharing services, the value of medallions has plummeted over the last decade or so — in New York, for instance, the value of a medallion dropped from around $1 million in 2014 to $100,000 in 2021. That’s in tandem with a drop in earnings, leaving many struggling to pay off enormous loans they took out to buy a medallion.

Some jurisdictions have sought to offset that collapse in medallion value. Quebec pledged $250 million CAD in 2018 to compensate cab drivers. Other regulators, particularly in Australia, applied a per-ride fee to ride-sharing services as part of efforts to replace taxi licenses and compensate medallion holders. In each of those cases, taxpayers and riders, not rideshare companies, bore the brunt of the impact on medallion holders.

At first it was just cab drivers that were hurting, but over the years, compensation for this new class of non-employee app drivers dried up too. In 2017, Uber paid $20 million to settle allegations from the Federal Trade Commission that it used false promises about potential earnings to entice drivers to join its platform. Late last year, Uber and Lyft agreed to pay $328 million to New York drivers after the state conducted a wage theft investigation. The settlement also guaranteed a minimum hourly rate for drivers outside of New York City, where drivers were already subject to minimum rates under Taxi & Limousine Commission rules.

Many rideshare drivers have also sought recognition as employees rather than contractors, so they can have a consistent hourly wage, overtime pay and benefits — efforts that the likes of Uber and rival Lyft have been fighting against. In January, the Department of Labor issued a final rule that aims to make it more difficult for gig economy companies to classify workers as independent contractors rather than employees. The EU is also weighing a provisional deal to reclassify millions of app workers as employees.

Of course, the partial erosion of an entire industry’s labor market wasn’t always the end goal. At one point, Uber wanted to zero out labor costs by getting rid of drivers entirely. It planned to do so by rolling out a fleet of self-driving vehicles and flying taxis.

“The reason Uber could be expensive is because you’re not just paying for the car — you’re paying for the other dude in the car,” former CEO Travis Kalanick said in 2014, a day after Uber suggested drivers could make $90,000 per year on the platform. “When there’s no other dude in the car, the cost of taking an Uber anywhere becomes cheaper than owning a vehicle. So the magic there is, you basically bring the cost below the cost of ownership for everybody, and then car ownership goes away.”

Uber’s grand automation plans didn’t work out as intended, however. The company, under current CEO Dara Khosrowshahi, sold its self-driving car and flying taxi units in late 2020.

Uber’s success had second-order effects too: despite a business model best described as “set money on fire until (fingers crossed!) a monopoly is established” a whole slew of startups were born, taking their cues from Uber or explicitly pitching themselves as “Uber for X.” Sure, you might find a place to stay on Airbnb or Vrbo that’s nicer and less expensive than a hotel room. But studies have shown that such companies have harmed the affordability and availability of housing in some markets, as many landlords and real-estate developers opt for more profitable short-term rentals instead of offering units for long-term rentals or sale. Airbnb has faced plenty of other issues over the years, from a string of lawsuits to a mass shooting at a rental home.

Increasingly, this is becoming the blueprint. Goods and services are exchanged by third parties, facilitated by a semi-automated platform rather than a human being. The platform’s algorithm creates the thinnest veneer between choice and control for the workers who perform identical labor to the industry that platform came to replace, but that veneer allows the platform to avoid traditionally pesky things like legal liability and labor laws. Meanwhile, customers with fewer alternative options find themselves held captive by these once-cheap platforms that are now coming to collect their dues. Dazzled by the promise of innovation, regulators rolled over or signed a deal with the devil. It’s everyone else who’s paying the cost.


Engadget 20th anniversary bannerEngadget 20th anniversary banner

To celebrate Engadget’s 20th anniversary, we’re taking a look back at the products and services that have changed the industry since March 2, 2004.

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Philips Hue lights to work way better with Samsung TVs and SmartThings, for a price

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Philips Hue is expanding its partnership with Samsung SmartThings, giving users greater control over how their smart lights “interact with their home entertainment systems.” To achieve this, Philips will launch a major update to its Sync TV app that’ll introducing a handful of new features. Philips is even changing the software’s subscription model to be more financially comfortable.

Starting from the top, people will be able to adjust settings on certain Samsung TVs via the app, without interrupting a movie or show. This includes changing different lighting modes on the fly as well as choosing when to start or stop content syncing. 

Additionally, users can create “multi-device automations”. These are smart home profiles that’ll work in collaboration with your Samsung TV instead of keeping the display isolated from everything else. Samsung says you can synchronize the lighting fixtures with “other smart home devices to enhance [the] TV-watching environment.”

Philips Hue's new Music Mode

(Image credit: Philips Hue)

Select 2024 Samsung TVs will also receive a Music Mode that’ll cause the lights around your display to react to the audio being played. Dance beats, for example, will see the fixtures pulsate to the rhythm. Looking at the official image, it appears you tweak the level of intensity.

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How does a cancer vaccine work?

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Vaccines are usually used to prevent infectious diseases. A therapeutic cancer vaccine is different. Rather than teaching the immune system to recognize pathogens in advance of an infection, these vaccines use identifying proteins produced by cancer cells, known as antigens, to provoke a powerful immune response to existing tumours.

A variety of approaches

The first step is to deliver antigens to immune cells called dendritic cells. These present antigens to other immune cells, and stimulate a response. In the past decade, several approaches have emerged1. One delivers antigens that are shared by many people with the same type of cancer (2). Others, including those that make use of messenger RNA (mRNA) technology, are highly personalized to the unique neoantigens produced by an individual’s tumour (3). Other personalized approaches involve injecting dendritic cells that are pre-loaded with cancer antigens (1), or generating antigens inside the body and promoting their uptake by dendritic cells in situ (4).

An infographic illustrating four approaches for presenting antigens to immune cells to stimulate an immune response.

Infographic: Alisdair Macdonald

Mounting a response

Unlike preventive vaccines, which focus mainly on activating antibody-producing B cells, a therapeutic cancer vaccine must generate a strong T-cell response. Dendritic cells loaded with tumour antigens bind and activate CD8+ cytotoxic T cells, which can then mount an attack on the tumour2.

Dendritic cells loaded with tumour antigens bind and activate CD8+ cytotoxic T cells, which can then mount an attack on the tumour.

Infographic: Alisdair Macdonald

Promising results

Numerous therapeutic cancer vaccines, on the basis of a variety of approaches, are showing encouraging results in trials.

Pancreatic cancer: In a phase I trial of a personalized mRNA vaccine, half of the participants developed T cells targeted to cancer neoantigens6. Recurrence-free survival in this group was longer compared with those who did not respond.

Pancreatic cancer cells.

Infographic: Alisdair Macdonald

Melanoma: A phase II trial of a personalized mRNA vaccine showed a 44% decrease in the risk of post-surgical recurrence or death7. A phase III trial is under way, with final results expected in 2029.

Melanoma cancer cells.

Infographic: Alisdair Macdonald

Lymphoma: A phase I/II trial of an in situ vaccine that combined radiotherapy with signalling molecules that mobilize and activate dendritic cells showed evidence of tumour regression in 8 of 11 people who were treated8.

Lymphoma cancer cells

Infographic: Alisdair Macdonald

Obstacles ahead

The future development and the clinical uptake of therapeutic cancer vaccines will be shaped by several factors.

Three obstacles.

Infographic: Alisdair Macdonald

Unwieldy trials. Testing multiple combinations of agents makes clinical trials more complex. Another complicating factor is timing when to give a vaccine relative to other interventions, such as surgery.

Immunity monitoring. Tracking acquired immunity is important for assessing vaccine efficacy. For cancer vaccines, new T-cell monitoring techniques are needed.

Scalability. Personalized cancer vaccines could pose logistical challenges. Streamlining production will be essential to keep costs down and availability high.

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how pranking at work can lift lab spirits

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Green "bunny ears" cactus with googly eyes on a bright pink background

Harmless lab pranks, such as spraying objects with unexpected scents or adding googly eyes, can lift spirits and encourage research-group bonding.Credit: Juj Winn/Getty

On 1 April 2022, John Prensner, then a postdoctoral researcher in cancer biology, received a surprising letter. Typed on official-looking letterhead paper, the message outlined plans for a Smithsonian Institution exhibit dedicated to the Human Genome Project, which in 2001 produced the first draft sequence of the human genome. Through professional connections, the writer said, they had learnt that Prensner held a piece of that history on his lab bench at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts: a PTC-200 machine used for PCR reactions during the pioneering work.

The machine had been inherited from a colleague at the nearby Whitehead Institute, where much of the project’s research was done, and was a favourite of Prensner’s because it was so simple to operate. He used the PTC-200 exclusively, and by then it was nearly as old as he was. When it finally stopped working, Prensner took the machine apart to try to fix it. But it never woke again, collecting dust until the letter arrived. “I wouldn’t get rid of it because I loved it so much, so I was excited that it might get a second life,” he says. “Until I turned the letter over.”

On the back, the letter stated that the Smithsonian was also interested in antiquated sound technology, including Prensner’s barely functioning 1995 boom box. Tipped off by the halo of labmates lurking surreptitiously around him, he soon realized that the whole thing was probably a prank. “Fortunately, the lab had a very positive atmosphere, so there weren’t any ill feelings,” Prensner says, adding that when he left in 2023 to start his lab at the University of Michigan Medical School in Ann Arbor, he trashed the PCR machine, but kept the boom box and letter.

Practical jokes such as this play out in labs every day, and many live on as group lore, stretching across generations of students and staff. Pranks, it turns out, are about much more than a laugh, and can serve important purposes — as tools for community-building, creative outlets in an otherwise intense working environment and as a means of passing on guidance. And although jokes can take nearly any form, there are underlying rules that define if and when pranking is appropriate. (Lab safety comes first: no researchers or experiments were harmed by these pranks.)

“The basis of a good prank is that you have to like and respect the person you’re pranking,” says Jess McLaughlin, who once hid tiny plastic horses they had found in a box on the kerb all throughout their lab when they were doing a genomics postdoc at the University of California (UC), Berkeley. “You’re not there to cause someone distress — you’re doing it with the person rather than to them.”

A prankster’s playbook

Some scientists, including McLaughlin, approach pranking opportunistically — striking when the Universe provides. Others pursue it with intention. Monica Tomaszewski , a programme manager at the University of Pittsburgh in Pennsylvania, recalls glueing down teachers’ chalk at school, but her pranking talents truly blossomed during her PhD at the same university. There, she discovered that her adviser, who is now retired, had a similar sense of humour. Because he was Canadian, Tomaszewski planned a prank to make his office smell like maple syrup. She bought candle-scenting solution, and each spring, applied it to his radiator, where he kept a collection of some 70 cacti.

“His office would smell like syrup for a few weeks, and he had no idea why,” Tomaszewski says. But one day, he quietly shared his suspicions with her — that his cacti were going into heat and releasing pheromones. “It was such a ridiculous sentence, because cacti don’t have a mating cycle, and he is a very intelligent biologist,” she says. Tomaszewski nearly gave away the prank then and there, but ultimately kept it up — even passing the scenting solution to lab colleagues when she moved on — before finally confessing over lunch one day several years later.

This idea of ‘pranking up’ — targeting people in positions of authority — is one of the many unspoken rules of practical jokes, alongside pranking laterally by targeting friends and peers. But to a fault, researchers who spoke to Nature say that pulling pranks on people over whom you hold power is poor form.

Social cues also determine whether pranking is appropriate. Jennifer Phillips, a research associate in genetics at the University of Oregon in Eugene, says that it often comes down to whether it’s “the right time, in the right place, with the right people”. Not all labs embrace a culture of pranking, and group dynamics are constantly in flux as people come and go. But when Phillips joined the university for her PhD in 1998, “the lab was made up of a unique group of people who really put fun in the centre of the table”, she says.

An ongoing prank involved the timers used to track experiments. Good etiquette dictates that people quickly silence beeping alarms to avoid disturbing others, but that didn’t always happen. A first infraction might earn you some gentle ribbing, but that quickly escalated to snack bribes to recover hidden timers, rude words etched into offending timers and, in the worst cases, timers embedded in agarose gel. Phillips says there were few instances in which people didn’t catch on quickly.

Pranks helped to create a more egalitarian environment, she says. “Having fun made it easier to approach each other if someone had a question,” she says, noting that that was especially true for her, as a new student. “And the flip side is that we would also have intense lab meetings, where people would really go hammer and tongs on your data. The collegial lab culture made those criticisms seem more constructive and less personal.”

Indeed, among the researchers who spoke to Nature, leveraging humour to strengthen social bonds was a common reason why people prank. For example, Tomaszewski and her labmates were cleaning out lab stocks one day in 2006, when they found a bottle of calcium chloride solution that was one month shy of its 21st birthday. Rather than toss it, the group held a birthday party to celebrate. “We put one of those little triangular birthday hats on it,” she says, and they later adjourned to a local bar called Filthy McNasty’s to toast the bottle’s coming-of-age.

Although targeting junior or new people with pranks is discouraged, it’s perfectly reasonable to bring them in on the joke as co-conspirators. Back in 2015, independent palaeontologist Lisa Buckley pulled the summer rotation students into a long-standing prank war between herself and her husband, fellow palaeontologist Richard McCrea.

Buckley saw the move as a form of teamwork that strengthened otherwise temporary bonds. She and the students printed out cat pictures and crafted dozens of tiny pom-pom cats, which they scattered throughout McCrea’s office at the Peace Region Paleontology Research Centre in Tumbler Ridge, Canada, where the couple worked as curators. In retaliation for these ‘cat wars’, McCrea launched ‘the spidering’ — when Buckley returned from a week of field work, she found her office completely engulfed in fake webs and hundreds of fake spiders, including a giant one over her desk and another dangling underneath. Both Buckley and McCrea discovered cats and spiders among their possessions for years afterwards — squashed between pages in books or hidden in boxes — even after they’d each left for new positions. Buckley says there are probably more still hidden in the lab, along with an Annoyatron noisemaker she left in the ceiling that periodically emitted a cricket chirp.

“I pity the person that has to inhabit any of those offices,” she says.

The purpose of play

Pranking does take time and energy, but some scientists stress that it’s worth the small dent in productivity because of the positive benefits of humour and play — including offsetting the intensity of academic careers. Increasingly, early-career researchers face a demoralizing duo of stagnating wages and poor job prospects. Pranking, researchers say, serves as a pressure-release valve that keeps people invested in the work they’re doing. “Doing something silly with your lab, whether that’s pulling a prank or going out to karaoke, lets you remember that there’s joy in the work,” Tomaszewski says.

A small memorial scene has been set up around a few dead insects on a stairwell ledge

A dead millipede in Rachel Thayer’s former lab building inspired passers-by to create a memorial scene, complete with other dearly departed lab specimens.Credit: Rachel Thayer

Rachel Thayer, now a postdoc in evolutionary biology at UC Davis, had a similar experience in 2018 while she was a PhD student at UC Berkeley. For weeks, a dead millipede lay in the stairwell that Thayer used to access her lab, until one day, a funerary scene popped up around it — complete with a headstone, a priest and some shrubbery. Other students quickly added to the display, often using dearly departed model organisms from their work. Thayer contributed a butterfly from her research on the evolution of structural colour, which rested alongside fruit flies and pill bugs. “It changed trudging up and down the stairs into an inside joke,” she says, adding that it was “a light-hearted, silently shared moment in an otherwise boring and repetitive part of the day”.

Indeed, researchers recall past pranks with fondness, particularly those who say they have since matured into boring, non-pranking adults. Daniel Bolnick, now an evolutionary biologist at the University of Connecticut in Storrs, was a solid jokester earlier in his career. He once placed a life-like rubber hand in a colleague’s −80 °C freezer and, as a student, designed a poster at a conference claiming to provide scientific evidence of the butterfly effect — an aspect of chaos theory that describes how the flap of a butterfly’s wings can lead to a typhoon on the other side of the world. He watched as his co-prankster, Evan Preisser, now a community ecologist at the University of Rhode Island in Kingston, presented the work under an assumed name. “Folks either got it or they didn’t,” Preisser says. “People in the latter group tried to educate us, and a few got agitated that they knew we were wrong but couldn’t prove it.”

Recalling these pranks, Bolnick says, feels cathartic, “because it does bring to mind times when I tapped into the creativity of science.” He adds that he might even feel compelled to start pranking again, albeit beginning with something gentle. As it happens, some of his former students are now faculty members in his department — and as staff of the same station, he thinks they are fair game. “That makes it easy — I know exactly who my first victims would be.”



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