Computationally restoring the potency of a clinical antibody against Omicron

Antibody and antigen production We experimentally validated the 376 designed candidates. To leverage available resources at multiple experimental sites, we split candidates into partially overlapping sets 1 and 2. Set 1 consisted of 230 designs expressed as IgG in HEK-293 cells (ATUM), and set 2 consisted of 204 designs expressed as IgG via a pVVC-mCisK_hG1 … Read more

Wild women and restoring public trust: Books in brief

The Rich Flee and the Poor Take the Bus Troy Tassier Johns Hopkins Univ. Press (2024) An adage in epidemiology states that, if you’ve seen one epidemic, you’ve seen one epidemic. However, argues economist Troy Tassier in his thoughtful history, in almost every epidemic, the rich escape and survive while the poor stay and suffer. … Read more