Computationally restoring the potency of a clinical antibody against Omicron

Antibody and antigen production We experimentally validated the 376 designed candidates. To leverage available resources at multiple experimental sites, we split candidates into partially overlapping sets 1 and 2. Set 1 consisted of 230 designs expressed as IgG in HEK-293 cells (ATUM), and set 2 consisted of 204 designs expressed as IgG via a pVVC-mCisK_hG1 … Read more

electrochemist whose techniques underpin clinical diagnostics, materials discovery and more

Credit: The University of Texas at Austin Allen Bard is widely regarded as the father of modern electrochemistry. During his prolific research career, including more than 60 years at the University of Texas (UT) at Austin, Bard became a world-renowned innovator and researcher, pioneering diverse areas of electrochemistry and technologies that are widely used today. … Read more

How AI is being used to accelerate clinical trials

Credit: Taj Francis For decades, computing power followed Moore’s law, advancing at a predictable pace. The number of components on an integrated circuit doubled roughly every two years. In 2012, researchers coined the term Eroom’s law (Moore spelled backwards) to describe the contrasting path of drug development1. Over the previous 60 years, the number of … Read more

Numbers highlight US dominance in clinical research

As the leading country in health-sciences output in the Nature Index, the United States’ Share is almost 8,500, higher than the next 10 leading countries combined. As a result, US institutions feature prominently among the leading research organizations for the subject, with 30 of the top 50 being based there. The country’s dominance means that … Read more