Digital wallets have emerged as a transformative force in how people pay for things in recent years as digital technology, especially via mobile phones, has accelerated in the 21st century. The first ever digital wallet is widely accepted to have been created by Coca-Cola in 1997 in Helsinki, enabling consumers to make purchases at a vending machine via text message. Nearly three decades later we are seeing a rapid shift in consumer behavior as the once niche technology reaches maturity and establishes itself in the mainstream.
Digital wallets are reshaping the landscape of commerce in the UK. By exploring the rise of this technology, we can also look to see how digital wallets could be fueling growth, consumer confidence, and its broader impact on retail and commerce.
Digital wallets reach the mainstream
Digital wallets are applications that store payment information and can be used online or in stores to quickly transmit payment information either through a simple click of a button or by tapping a device to a payment terminal. These wallets are often funded by linking the app to a credit or debit card or even directly to a bank account.
Digital wallets have evolved from being a novel concept to a ubiquitous payment method in the UK. By 2027, digital wallets are expected to account for half of all ecommerce platform spending in the UK, totaling an impressive £203.5 billion in total transaction value. Additionally, usage of digital wallets at UK point-of-sale (POS) is projected to more than double, rising from 14% to 29% of transaction value by 2027 showing the meteoric rate of adoption. But if this technology has been around since 1997, then why is it only recently seeing such growth?
James Fry
James Fry is Head of Strategic Expansion, Worldpay
Innovation is a driver of change
While there was novelty in making payments via text message to buy a soda, the impressive rise of digital wallets and mobile payments is really the confluence of several highly advanced but disparate technologies becoming commonplace. For example, biometric authentication, such as fingerprint or facial recognition, in smartphones has significantly enhanced the security of digital transactions. Furthermore, near-field communication (NFC) technology, which has allowed UK consumers to make contactless payments for a long time, has also been embedded in smartphones, allowing people to use their devices to pay for things in person.
As these technologies have been woven into smartphones and as smartphones have found a place in nearly every Briton’s hand, people are discovering the beautiful convenience and simplicity of digital wallet payments.
Consumer confidence is the foundation of behavioral shifts
The familiarity with and maturity of these technologies has reached a tipping point for UK consumers instilling them with the confidence to explore new payment methods like digital wallets. The shift in behavior is significant especially when you consider the size of the UK e-commerce market which is the world’s third-largest and expected to continue growing at a 7% compound annual growth rate (CAGR) through 2027. Digital wallets will account for half of all online and 37% of in-store purchases by transaction value by 2027, showing how, as consumers become more comfortable with digital wallets, their usage will continue to grow rapidly.
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How digital wallets change retail
The adoption of digital wallets is not only changing how consumers pay for goods and services but also influencing retail strategies. We are seeing now that merchants are investing in advanced payment strategies online, offering a wider array of embedded payment options to meet customer preferences as well as upgrading their payment terminals in stores to accept more payment types like digital wallets. As merchants look for every competitive advantage available to them, their strategies are increasingly looking to offer consumers more conveniences like enabling digital wallet acceptance across all channels.
The rise of digital wallets: Summary
In conclusion, the rise of digital wallets in the UK represents a significant shift in the way people shop and buy goods and services. As technology continues to advance and consumer behavior evolves, digital wallets are poised to become the dominant form of payment in the country and across the globe. Retailers and businesses that embrace this change stand to benefit from the convenience and security that digital wallets offer, positioning themselves at the forefront of the UK’s payment revolution.
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Johnblack Kabukye struggles to explain to his colleagues back home in Uganda why he’s doing a two-year stint as a postdoctoral researcher in Sweden. “If you say you’re doing a master’s or a PhD, it’s clear what that means,” says the digital-health specialist, who worked as a physician for a decade before switching to research. But a postdoc? “It’s not a thing that is understood,” he says.
The skills he’s learning at Stockholm University while building electronic health tools tailored to patients’ needs are certainly useful for his job as a physician and informatician at the Uganda Cancer Institute (UCI) in Kampala. But the postdoc format itself — a short-term position designed to bridge the gap between doctoral student and tenured academic — makes little sense in Uganda, where it is common to have a permanent teaching job at a university before even embarking on a PhD.
“I have not heard of a single postdoc opportunity in Uganda,” Kabukye says.
Career resources for African scientists
That could soon change across Africa. The number of people gaining PhDs in the continent is growing, and so is the need for postdoctoral employment. “There is definitely greater awareness of the postdoc position, and more and more postdocs,” says Gordon Awandare, pro-vice-chancellor in charge of academic and student affairs at the University of Ghana in Accra.
But as the continent’s postdoctoral employment needs have grown, so too have fears that the problems created by a proliferation of postdoc positions in other parts of the world — which critics say trap young researchers in a cycle of poorly paid, short-term positions with no job security — could also arise in African countries.
Breaking ground
Postdoc frustration is a recurring theme in studies that look at early-career researchers. Two global surveys of postdoctoral students by Nature, one published in 2020 and the other last year, found that more than one-third of respondents were dissatisfied with their lot. A lack of job security, career-advancement opportunities and funding were the most-cited reasons.
Nature’s surveys underscore the dearth of postdoctoral researchers in Africa. Of the 3,838 postdocs surveyed in June last year, only 91 were based on the continent. The number of respondents (who were self-selecting) were too few, and too geographically concentrated in three countries — South Africa, Nigeria and Egypt — to be viewed as representative of the continent. Yet, they offer tantalizing glimpses of an emerging segment of the global research workforce.
For example, African postdocs were older than the global average, with more than 40% aged 41 or older. They were also more likely to be doing their postdoc in their home country (68% in Africa compared with 39% globally) and they were much less likely, than the global average, to be employed on fixed-term fellowships or contracts (see ‘Employment matters’). Their pay also stands out: 60% said they earned less than US$15,000 per year — the lowest option survey-takers could tick, and a fraction of what most postdocs are paid in Europe and North America. Lower costs of living play some part in the lower salaries, but not enough to justify the gap (see ‘A continental shift’).
Postdocs in Africa were also more likely to report having a second job alongside their postdoc than were other respondents, on average (33% of respondents in Africa, compared with 10% of respondents overall). The most common reason was to provide extra income (71%), while 57% said their second job gave their skills and career prospects a boost. However, notes Awandare, the tendency of many African postdocs to have permanent academic positions before becoming a postdoc could be a confounding factor in this measure.
Yet, and perhaps surprising given their low pay, Africa-based postdocs were the most optimistic about their futures of all respondents from the geographical regions represented. Overall, 64% of Africa-based respondents reported that they felt positive about their future job prospects, compared with 41% globally. Postdocs in Africa were twice as likely to say that their postdoc roles were better than they imagined (25% compared with 12% overall). And 42% of respondents in Africa felt that they had better prospects than previous generations of postdocs, far exceeding the 15% global average.
That optimism makes sense to Awandare, who thinks that postdocs in his country might feel more important than do their peers who work in large laboratories overseas. In addition to his leadership role at the University of Ghana, he founded and runs the West African Centre for Cell Biology of Infectious Pathogens at the university. He says postdocs at the centre are treated the same as faculty members. “In some advanced institutions, they wouldn’t get that recognition and status,” he notes.
And even though their salaries are low by international standards, postdocs at his centre can be better paid than entry-level permanent university staff who only teach, he says. This is because postdocs tend to be paid out of lucrative international grants. “Ten to fifteen years ago, many of these positions would have been overseas — but now funders, to their credit, increasingly provide positions on the continent,” he says.
A different set-up
Employment structures also differed between Africa and the rest of the world, according to Nature’s survey. Although similar proportions of postdocs were employed in academia in Africa as they were globally (around 90%), the proportion of part-time postdocs was higher in Africa — 12% compared with the global average of 5%. One of them is Felista Mwingira, a parasitologist at the University of Dar es Salaam in Tanzania. She exemplifies how African early-career researchers have been forging ahead in their research careers in the absence of a formal structure of postdoc positions.
Mwingira obtained her PhD in 2014 from the University of Basel in Switzerland at the age of 33 — which she says is very young for researchers in Tanzania. By the time she started her studies, she was already permanently employed by her university in Tanzania, and was able to return to that post after finishing her PhD. Back home, she could take three months paid maternity leave for each of her two children, born four years apart. And although juggling pregnancies and bringing up children with the demands of an academic career was a challenge, it meant she had job security — something postdocs at the same stage in their lives in other parts of the world often lack.
Falling behind: postdocs in their thirties tire of putting life on hold
Mwingira’s work after her PhD was not technically a postdoc. But as her children got older, she sought out a mentorship arrangement at her university that provides her with research training and, sometimes, extra money from the projects she works on. It’s not a formal postdoc, but she hopes it will help her to attain the publication ‘points’ required in the Tanzanian university system to progress up the academic career ladder — something that does not depend on more-senior positions becoming available. She hopes to be promoted in the near future, but says she would also like to embark on a full-time postdoc position to “sharpen my scientific skills”.
So far, Mwingira considers herself lucky. Her children are now four and eight, and while she says that her life as an early-career academic still has ups and downs, she is thankful for the stability she has enjoyed so far in her career. “I think that I’m better off compared to postdocs in high-income countries.”
That feeling of being better off than people elsewhere certainly does not translate to sub-Saharan Africa’s most prominent research nation: South Africa. There, postdoc numbers have been rising for a couple of decades, growing from around 300 in 1999 to nearly 3,000 in 2019 (ref. 1), and national surveys reveal postdoc frustrations that mirror those raised globally, with some country-specific gripes to boot.
Heidi Prozesky is a research scholar at the Centre for Research on Evaluation, Science and Technology at Stellenbosch University. She is one of the people behind South Africa’s first PhD tracer study, published in its final form in July 2023, which tracked the whereabouts of nearly 6,500 PhDs who had graduated in the country between 2010 and 2019. That survey found that around 20% had accepted at least one postdoctoral fellowship, either at home or abroad, on completing their PhDs, with a steady growth seen over the two decades. The postdocs spent a median of three years in the position, although one-quarter reported spending more than four years. One-third reported having accepted more than one postdoc — often, they said, because other work was not available.
Career resources for postdoctoral researchers
A common refrain in the South African survey, which echoes the findings of Nature’s global surveys, is that postdocs feel like they are in limbo: neither students nor staff. In reality, postdocs in South Africa are technically students. This saves them from paying tax on their income, which are stipends, not salaries. But this designation also breeds resentment, because it means postdocs are treated like students: they can’t apply for grants and typically have no funding to travel to conferences or attend workshops.
In addition to the lack of opportunities, postdoc pay in South Africa is low compared with living costs. Last year, the National Research Foundation’s non-taxable postdoc stipends started at 200,000 rand (US$10,700). Female postdocs are allowed up to four months paid maternity leave. However, basic private medical insurance does not come as standard, meaning that postdocs have to pay for it out of their stipends if they want to avoid state health care, which many people in South Africa view as woefully inadequate. The stories of some postdocs “would make you cry”, says Palesa Mothapo, who heads research support and management at Nelson Mandela University in Port Elizabeth, South Africa. “These people have PhDs. And they end up going hungry.”
Growing pains
South Africa’s predicament stems partly from bottlenecks in the academic careers system. The number of people with a PhD graduating annually more than tripled between 2000 and 2018, increasing the demand for postdoctoral work. Postdoc positions have also increased, but further up the career ladder, the number of roles has been static. A study published this year1 in the South African Journal of Science found that the number of postdoc positions grew ten times faster between 2007 and 2019 in the country than did the growth in entry-level permanent jobs in academia.
Palesa Mothapo at Nelson Mandela University in Port Elizabeth, South Africa, says there needs to be more discussion around transferable skills for African postdocs.Credit: Stefan Els
But many also view South Africa’s postdoc malaise as a consequence of incentive structures in the country that place a premium on research publications. Postdocs have become cheap, low-commitment hires for universities that want to boost their output of research publications, which in South Africa earn the host institutions or departments cash subsidies from the government. Postdocs often have publication targets written into their appointments, Mothapo says. “But those papers don’t translate to money for the postdoc. It goes to the institution, to the host.”
There is some cause for cheer. Last December, the National Research Foundation announced it would raise its minimum annual postdoc stipend to 320,000 rand per year for new fellowships from 2024. But simply increasing postdoc stipends is unlikely to create more academic positions for postdocs who are looking for more job security. And the bottleneck seems to be worse for some groups. According to Prozesky, South Africa attracts a lot of postdocs from the rest of the African continent. Most come with the expectation that it will lead to a permanent job. The PhD tracer study found that many people from the rest of Africa end up disillusioned and feeling discriminated against. They struggle to move on from the postdoc status, and can face long delays in visa approvals when moving between posts. “They call it academic xenophobia,” says Prozesky.
Charles Teta, a Zimbabwean environmental chemist who did two postdocs in South Africa after a PhD in his home country, says that he noticed that South African citizens were less likely to take the postdoc route than were immigrants like him. “South Africans are more likely to get lectureship posts,” without having any postdoc experience, he says. In addition, a growing number of funding streams are not open to non-citizens — even those who are permanent residents. Eventually, those restrictions cause people to leave, he says.
Teta left South Africa last year to cover the maternity leave of an environmental-science lecturer at Queen Mary University of London. There, he enjoys the opportunity to teach — something he wasn’t expected to do during his postdocs. It’s been a happy choice so far, and he hopes to find another, similar position when his current one ends. He doesn’t miss the research treadmill, which, he says, “did not translate to mental and financial well-being”.
A call for creativity
Mothapo says that the rigid focus on research in South African postdoc roles is part of their problem. “The universities are not creative,” she says. Because postdocs are limited in how they can teach, and can’t apply for their own funding, she notes, they are missing out on learning skills that are beneficial for staying in academia, and that could open up alternative career paths in industry.
More-creative programmes have been trialled across the continent. Since 2019, the US National Institutes of Health (NIH), the Bill & Melinda Gates Foundation in Seattle, Washington and the African Academy of Sciences have been running the African Postdoctoral Training Initiative (APTI). The programme combines a two-year postdoc at a NIH institute in the United States with a two-year research grant that fellows can take back home to build their own research programmes. Notably, it is open only to researchers who have permanent positions already.
Postdoc career optimism rebounds after COVID in global Nature survey
Daniel Amoako-Sakyi, an immunologist at the University of Cape Coast, Ghana, embarked on an APTI fellowship in late 2023. He is a postdoc in mid-life, and the fellowship has proved to be a good fit. He is a few months into his position at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, where he will spend the next two years looking at biological reasons for the variance in efficacy seen in new malaria vaccines. His 15-year-old daughter has enrolled in a US high school, and his spouse, a fellow academic, aims to split her time between the United States and Nigeria.
In Bethesda, Amoako-Sakyi has none of the resource constraints that limit him in Ghana. Antibodies that would take months to ship to his home country arrive on his doorstep overnight. He expects the opportunity will supercharge his career, and hopes he’ll be able to take on some postdocs of his own when he returns home. He doesn’t expect it will be difficult to find them. “I think most researchers are looking for the right environment to flourish,” he says.
What comes next?
There are few certainties about the future of African postdocs. Those who spoke to Nature hope that their postdoc training will accelerate their careers — by helping them to win grants, get promotions and expand their research networks. In Uganda, Kabukye hopes to have organized funding and collaborators by the end of his postdoc so that he can carry on his research designing and implementing digital-health tools in resource-constrained settings. “Ideally, I would have positions at the UCI and at another university, to foster collaboration and exchange,” he says.
Physician Johnblack Kabukye from Uganda is doing a postdoc building electronic health tools at Stockholm University in Sweden.Credit: Johnblack Kabukye
However, with most of the continent’s research funding still coming from sources outside Africa — with the exception of a handful of countries, such as South Africa and Egypt — it’s likely that foreign funding will keep driving the creation of postdoc opportunities. And that can mean the positions aren’t always tailored to local needs.
Mothapo says that she often hears research funders talk about the need to create more postdoc positions. However, there is not enough discussion around the particular needs that African postdocs will have, especially the transferable skills that they will need if they want to transition to sectors such as industry. “I’m worried about their destinations,” she says.
Mwingira echoes her concern. She thinks that more formalized postdocs in Tanzania could lead to bottlenecks in the training system, as has been seen in South Africa and elsewhere. “Those problems will arise in Tanzania, too, but worse, because of the low salaries,” she says.
But Amoako-Sakyi does not think that the creation of more African postdocs has to result in frustration as they compete for rare academic posts. Many might already be employed by universities at that point in their careers. A postdoc could allow them to win grants from funders so that they can set up their own research groups and create opportunities for the next generation. He also thinks that the biotechnology industry in countries such as Ghana will grow, further increasing the demand for researchers in the country.
Nor does Amoako-Sakyi think that African postdocs need to end up in the same negative landscape that postdocs occupy elsewhere in the world. Such fears are not unfounded, he says, because concepts are often brought to the continent and adopted without thinking about the local context. But as his own fellowship shows, there are ways to tailor postdocs to African settings. “We should be very intentional about how we do it and try to correct old mistakes.”
Fighting off rising seas without reducing humanity’s carbon emissions is like trying to drain a bathtub without turning off the tap. But increasingly, scientists are sounding the alarm on yet another problem compounding the crisis for coastal cities: Their land is also sinking, a phenomenon known as subsidence. The metaphorical tap is still on—as rapid warming turns more and morepolar ice into ocean water—and at the same time the tub is sinking into the floor.
An alarming new study in the journal Nature shows how bad the problem could get in 32 coastal cities in the United States. Previous projections have studied geocentric sea-level rise, or how much the ocean is coming up along a given coastline. This new research considers relative sea-level rise, which also includes the vertical motion of the land. That’s possible thanks to new data from satellites that can measure elevation changes on very fine scales along coastlines.
With that subsidence in mind, the study finds that those coastal areas in the US could see 500 to 700 square miles of additional land flooded by 2050, impacting an additional 176,000 to 518,000 people and causing up to $100 billion of further property damage. That’s on top of baseline estimates of the damage so far up to 2020, which has affected 530 to 790 square miles and 525,000 to 634,000 people, and cost between $100 billion and $123 billion.
Overall, the study finds that 24 of the 32 coastal cities studied are subsiding by more than 2 millimeters a year. (One millimeter equals 0.04 inches.) “The combination of both the land sinking and the sea rising leads to this compounding effect of exposure for people,” says the study’s lead author, Leonard Ohenhen, an environmental security expert at Virginia Tech. “When you combine both, you have an even greater hazard.”
The issue is that cities have been preparing for projections of geocentric sea-level rise, for instance with sea walls. Through no fault of their own—given the infancy of satellite subsidence monitoring—they’ve been missing half the problem. “All the adaptation strategies at the moment that we have in place are based on rising sea levels,” says Manoochehr Shirzaei, an environmental security expert at Virginia Tech and a coauthor of the paper. “It means that the majority—if not all—of those adaptation strategies are overestimating the time that we have for those extreme consequences of sea-level rise. Instead of having 40 years to prepare, in some cases we have only 10.”
Subsidence can happen naturally, for instance when loose sediments settle over time, or because of human activity, such as when cities extract too much groundwater and their aquifers collapse like empty water bottles. In extreme cases, this can result in dozens of feet of subsidence. The sheer weight of coastal cities like New York is also pushing down on the ground, leading to further sinking.
Andrew Day, a molecular microbiologist at Tufts University in Medford, Massachusetts, is four years sober. His journey to this point inspires his work, which he hopes might help others who are struggling with alcohol.
Nature Outlook: The human microbiome
There are many risk factors associated with alcohol-use disorder (AUD), including mental-health conditions and genetics. But Day is eyeing a more unusual contributor: the gut.
Over the past decade, research has begun to highlight a link between the gastrointestinal microbiome — the microorganisms that live inside our digestive tract — and addiction. Researchers including Day suggest that an imbalance in the intestinal microbiota, known as dysbiosis, might cause the gut to send signals to the brain that promote addiction behaviours. If correct, the gut could become a treatment target for people with AUD. “I could find something that might make it easier for people who might not be as fortunate to maintain sobriety,” says Day, who is studying the theory that high levels of the fungus Candida albicans in the gut contributes to increased alcohol consumption in mice as part of his PhD.
This is a sharp departure from conventional medical approaches to treating addiction. Most drugs for AUD and substance-use disorder (SUD) focus on brain chemistry. Many of them are not very effective. Medications for AUD approved by the US Food and Drug Administration (FDA) include naltrexone and acamprosate. In addition, the European Medicines Agency (EMA) has approved nalmefene. Acamprosate modulates brain receptors such as those that bind γ-aminobutyric acid (GABA), an inhibitory neurotransmitter thought to have a role in withdrawal, craving and impulsive behaviour. Nalmefene and naltrexone modulate opioid receptors, nalmefene reduces alcohol cravings, and naltrexone blocks euphoric sensations associated with alcohol.
According to the US Substance Abuse and Mental Health Services Administration, only 42% of people who receive treatment for any kind of SUD complete that treatment1. Between 40% and 60% of people with an SUD will relapse, and it can take years — sometimes decades — of see-sawing between abstinence and relapse before someone achieves sustained remission. Clearly, there is room for improvement. “We’ve missed the target for 50 years,” says Benjamin Boutrel, a neurobiologist at Lausanne University Hospital in Switzerland. “Mostly because it’s not only a matter of the brain — it’s possibly a matter of the guts, too.”
The gut–brain axis
It is now well known that there is complex communication between the gut and the brain, through the vagus nerve as well as through the endocrine and immune systems. This gut–brain signalling has been suggested to influence addiction-related behaviours in two main ways.
Andrew Day hopes his research will help others who have alcohol-use disorder.Credit: Dr. Carol Kumamoto
The first involves a condition known as leaky gut. Stress, poor diet, food allergies, chemotherapy and other medication, conditions such as inflammatory bowel disease and — perhaps crucially — overuse of alcohol can damage the layer of epithelial cells that line the intestines. This can make the intestinal wall permeable to food particles and bacteria, which can then sneak into the circulatory system.
When this happens, immune cells secrete inflammatory mediators such as cytokines. These proteins can then reach the brain, either through the vagus nerve or by crossing weak areas in the blood–brain barrier, a layer of cells meant to protect the brain from damage.
The subsequent inflammation can affect the brain in several ways that could promote addiction. Cytokines deplete tryptophan, which can lead to reduced production of the mood-regulating hormone serotonin. The brain’s amygdala might sense a threat in the body and increase its activity in response to inflammation. The ventral striatum — the area of the brain related to reward anticipation — might also be ignited. The anterior cingulate cortex — the part of the brain involved in inhibitory control and compulsive behaviour — can also activate during inflammation.
Second, the molecules that gut microbes produce could influence addiction. Some of these are important for brain functioning. The gut bacteria Lactobacillus, for example, can produce GABA; Enterococcus can produce serotonin; and Bacillus can make dopamine. Short-chain fatty acids (SCFAs) released when dietary fibre is fermented by bacteria in the gut also have neuroactive properties.
Gut dysbiosis, and its subsequent impact on GABA, serotonin, dopamine and tryptophan, could, therefore, make a person more susceptible to addiction and mean that they experience more severe withdrawal symptoms than would someone with a healthy gut microbiome.
“The gut microbiome is really important for some organs, including the brain,” says Drew Kiraly, a psychiatrist and physician at Wake Forest University in Winston-Salem, North Carolina. Kiraly has observed associations between dysbiosis and addictive behaviour to stimulants and opioids in rats. He has used antibiotics to deplete rats’ beneficial gut microbes, resulting in “aberrant responses to drugs”. The animals had increased intake of cocaine and fentanyl, he says. “And after withdrawal, they relapse and have higher fentanyl-seeking behaviour.”
Addictive personality
Even before first contact with alcohol or drugs, pre-existing dysbiosis could make someone more vulnerable to addiction, Boutrel says. The imbalance could give rise to traits such as impulsivity, boredom, susceptibility to stress or anxiety, and sensation seeking. “Those who get thrilled with poker playing, with pathological sex, they all need something,” Boutrel says. “There is a vulnerability there that, once that first contact is made, will trigger repetition — and finally, addiction.”
Sophie Leclercq is one of few researchers able to study theories about the gut microbiome in people with alcohol-use disorder.Credit: Sophie Leclercq
In 2018, Boutrel and his colleagues put a group of 59 rats through a number of tests designed to assess their vulnerability to AUD2. First, the rodents were trained to self-administer alcohol by pressing a lever. The researchers then tried to gauge the rats’ self-control by introducing a delay to the reward delivery. Some rats pressed the button once, realized that they had to wait, and went about their business. But some would continue pressing over and over, attempting to make the alcohol arrive more quickly — an indication of addiction.
The final test, which Boutrel thinks is most telling, introduced a deterrent — an uncomfortable foot shock every time the animals took the alcohol. For most of the rats, this discouragement was sufficient and they stopped pressing the lever. However, a sizable minority “just didn’t care”, Boutrel says. “They could not stop pressing the lever and accessing the reward, even when they got a punishment.” In total, about 30% of the rats demonstrated vulnerability to AUD.
Having identified a group of vulnerable rats, Boutrel and his colleagues removed alcohol from the rats environment for three months, and then compared the brains and gut microbiomes of the vulnerable rats with those of rats that had proven more resistant to AUD. The team found that the vulnerable rats had more efficient dopamine 1 receptors (which trigger increased reward-seeking and motivation) and less efficient dopamine 2 receptors (which cause impulsivity, and an increased need for immediate rewards and drug administration). They also found differences in the bacterial content of the vulnerable-rat guts — most notably, changes in Lachnospiraceae, Syntrophococcus and other bacteria associated with reductions in dopamine 2 receptors. This, the researchers suggest, is an indication that gut microbiota could affect brain circuits associated with addiction.
Alcohol and other drugs
Sophie Leclercq, a biomedical scientist at the Catholic University of Louvain in Brussels, was an early advocate of the theory about an AUD gut–brain origin, and one of the first to test it in people3. Her aim was to find out whether intestinal permeability was related to character traits that might make people more susceptible to alcohol dependence.
Lactobacillus gut bacteria can produce the inhibitory neurotransmitter GABA.Credit: BSIP/UIG Via Getty Images
Leclercq and her colleagues tested the intestinal permeability of 60 people with AUD two days after they began withdrawal. The researchers found that 26 (43%) had high intestinal permeability. At the beginning of the study, everyone with AUD had higher scores of depression, anxiety and craving than did people in the control group. At the end of three weeks of abstinence, the scores of people with low intestinal permeability returned to levels equal to those of the control group. People with high intestinal permeability, however, still scored highly in tests of depression, anxiety and craving, which are directly related to the urge to drink and have a major role in whether people can abstain after detoxification.
“We wanted to see if there was some connection between the gut microbiota and the psychology of AUD, and, indeed, we found that there is a very strong association between dysbiosis, the alteration of the gut microbiota composition, and symptoms like depression, anxiety or grief,” Leclercq says.
Although much of this research is related to people with AUD, Kiraly says that they’ve seen similar results in people who misuse opioids, and cocaine and other stimulants. “Depletion [of microbiota] seems to dysregulate these networks that underlie behavioural changes,” he says.
In 2023, Kiraly and his colleagues looked at whether rats’ microbiomes affected the animal’s drug-seeking behaviours4. In one experiment, rats were given either clean water or water containing the antibiotics neomycin, vancomycin, bacitracin and pimaricin, all of which would deplete their gut microbiota. They were then let into a chamber in which they could push a lever that lit up and provided 0.8 milligrams of cocaine. Later, researchers altered how the lever behaved — now it would light up when pushed, but would have to be pushed more times for the rats to receive cocaine. Researchers found that the rats with depleted gut microbiota were much more likely to press the lever repeatedly to receive cocaine than were the rats given only water.
In a second experiment, both groups of rats were able to self-administer cocaine for two weeks, then detoxed for 21 days. When the rats returned to the cages in which cocaine was available, those receiving antibiotics headed to the lever that originally dosed cocaine twice as quickly as the other rats did. These rats also pressed the lever much more frequently than the control rats did.
“We wanted to study a model of relapse and we saw that microbiome-depleted animals work harder for a drug-related cue than the others did,” Kiraly said. “Lots of people use drugs and not all get to the stage of problematic use. It could be that your microbiome predisposes you.”
Treatment questions
There is still a lot of research that needs to be done before any microbiome-targeted treatment could be offered to people with AUD or another SUD. Researchers don’t yet know, for example, which microbiota are most important, and which gut–brain pathways they need to target. “People have asked me, ‘Can someone just eat yogurt and cure their addiction?’” Kiraly says. “It’s going to be much, much more complicated than that.”
Kiraly would like to see whether probiotics or other treatments could have potential for people with early problematic use but who have not yet progressed to AUD. For instance, some rats in Kiraly’s study were administered SCFAs alongside their antibiotics. Compared with rats that received only antibiotics, those also given SCFAs seemed to retain more Firmicutes and less Proteobacteria (many of which are pathogenic). Strikingly, when the post-detox rats were given the chance to consume cocaine again, those who had received SCFAs behaved like rats with normal gut flora.
Leclercq thinks that 30–40% of cases of AUD might have a gut-related component that could be targeted for treatment. A key challenge is determining exactly which components to target — it is as yet unclear what constitutes a ‘good’ microbiome. Day’s analysis suggests that bacteria such as Lactobacillus, were in abundance in people with AUD, whereas Akkermansia and some others were low.
There is also uncertainty regarding what would be the most effective and easiest part to target of the chain of communication between the gut and brain. Areas such as the nervous system, blood stream or the system surrounding the gut are all candidates.
It is also tricky to find people with AUD who are willing to not only abstain from drinking, but also take part in research, including providing samples of their gut microbiome. Leclercq is one of few researchers able to work with people, instead of rats, because she is affiliated with a hospital with a detoxification clinic. But even she can find it difficult to get enough volunteers for studies. In work assessing the effects of a prebiotic on people with AUD, the number of people with dysbiosis was around half that of those who had healthy guts, making comparisons between the two difficult. Leclercq’s analysis of this aspect of the study is yet to be published.
Despite these issues, Leclercq is moving forward with her research, and is now looking at nutrition as a way to improve the gut microbiome. She is starting a study on polyunsaturated fatty acids — such as those abundant in rapeseed and maize (corn) oils, walnuts, tofu and fatty fish, including salmon and mackerel — and hopes to have results in about two years. She’s also working to correlate which metabolites from food are related to depression, anxiety and craving, and trying to find funding for a study to test these particular nutritional compounds in people.
“Pharmaceutical companies have tried to target GABA, dopamine and serotonin, and these treatments aren’t very efficient because the relapse rate is very high in this disease,” she says. For people with AUD whose guts are contributing to their condition, nutritional interventions, probiotics and prebiotics could eventually improve the odds of success.
If you are looking forward to the premiere of the highly anticipated Apple TV documentary series about Lionel Messi. An Argentine professional footballer who plays as a forward for and captains both Major League Soccer club Inter Miami and the Argentina national team. Apple is giving you the chance to step into the life of one of the most iconic athletes of our time.
On February 21, 2024, Apple TV+ invites viewers to do just that with the premiere of “Messi’s World Cup: The Rise of a Legend.” This four-part documentary series takes you on a journey through the illustrious career of Lionel Messi, focusing on his remarkable experiences across five FIFA World Cup tournaments, and culminating in his 2022 World Cup victory with Argentina.
Apple Lionel Messi documentary
The series promises to offer an unparalleled look into the life of Messi, providing viewers with intimate interviews featuring his teammates, coaches, and ardent fans. These conversations aim to illuminate the profound influence Messi has had on the sport of football and his unwavering commitment to his national team. From his early days on the international stage to his ascent to legendary status, the documentary captures the essence of Messi’s resilience, his extraordinary talent, and his relentless pursuit of greatness.
Produced by the acclaimed SMUGGLER Entertainment in collaboration with Pegsa, the documentary is crafted by a team of award-winning producers. Their expertise ensures that Messi’s story is told with the depth and quality it deserves. But the exploration of Messi’s world doesn’t end with the documentary. Fans can continue to follow his current exploits with Inter Miami CF in the MLS through the Season Pass available on the Apple TV app.
This documentary series is more than just a chronicle of Messi’s achievements; it’s a tribute to his journey, a testament to his exceptional skills, and a celebration of his lasting impact on the world of football. Don’t miss the chance to experience the story of one of the sport’s most celebrated figures in “Messi’s World Cup: The Rise of a Legend,” exclusively on Apple TV+.
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On February 21, 2024, Apple TV will release a remarkable four-part documentary Messi’s World Cup: The Rise of a Legend. Promising to provide an intimate, in-depth look at Lionel Messi’s illustrious football career, focusing not only on his professional trajectory but also on the man behind the football legend.
The series, filmed in Paris, Qatar, and Messi’s home country Argentina, traces Messi’s journey from his humble beginnings to his rise as a global football superstar. The documentary offers exclusive behind-the-scenes access to Messi, arguably the greatest football player of all time, revealing aspects of his life and career that have never been seen before.
Messi’s World Cup: The Rise of a Legend is not merely a chronicle of Messi’s football career. It also provides an intimate look at Messi’s personal life, featuring personal interviews with Messi himself, as well as conversations with those who know him best – his teammates, coaches, competitors, fans, and commentators. These interviews and conversations serve to highlight Messi’s influence and impact on a national and global level, offering insights into Messi’s character and his role in shaping the world of football.
Messi Apple TV series premiers February 2024
At the heart of the documentary is Messi’s journey with the Argentina national football team, with a particular focus on his five FIFA World Cup appearances and his triumphant victory at the FIFA World Cup Qatar 2022. The series charts Messi’s journey from his first match with the Argentina national football team, through his unexpected early retirement in 2016, to his comeback and eventual crowning as the 2022 tournament’s best player.
The documentary also provides an in-depth exploration of Messi’s early retirement in 2016 and his subsequent return to the game. This aspect of the series serves as a testament to Messi’s resilience and determination, showcasing his ability to overcome adversity and rise to the top of his game.
The global premiere of The Rise of a Legend on Apple TV+ on February 21, 2024, is an event eagerly anticipated by football fans worldwide. The documentary promises to provide a unique and comprehensive look at Messi’s career and his influence on the world of football, offering viewers an unprecedented opportunity to gain a deeper understanding of the man behind the legend.
Messi’s World Cup: The Rise of a Legend is more than just a documentary about Lionel Messi. It is a tribute to his impact on the world of football, a testament to his resilience and determination, and a celebration of his incredible journey from his humble beginnings to his crowning as a football legend. The series promises to be a must-watch for football fans and non-fans alike, providing a unique and insightful look into the life and career of one of the greatest football players of all time.
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In today’s globalized world, the ability to communicate across languages and cultures is more crucial than ever. As businesses expand internationally, travelers explore new destinations, and digital content proliferates, the demand for accurate and efficient translation has skyrocketed. Enter online translation platforms, the unsung heroes of our interconnected age.
1. What are Online Translation Platforms?
Online translation platforms are digital tools or services that allow users to translate text or speech from one language to another. These platforms can range from simple text-based translators, like Google Translate, to more sophisticated systems that integrate with websites and applications, offering real-time translation for users.
2. The Evolution of Translation Platforms
The journey of online translation began with basic word-for-word substitutions, which often resulted in translations that were technically correct but lacked context or cultural nuance. However, with the advent of artificial intelligence (AI) and machine learning, these platforms have evolved significantly:
Machine Translation (MT): Early systems used rule-based methods, but modern MT employs neural networks and deep learning to produce more accurate and contextually relevant translations.
Real-time Translation: Platforms now offer real-time translation for live conversations, be it in messaging apps or video conferences.
Integration with Other Services: Many platforms integrate with websites, apps, and content management systems, allowing for seamless translation of digital content.
3. Benefits of Using Online Translation Platforms
Accessibility: Anyone with an internet connection can access these platforms, breaking down language barriers.
Cost-Effective: Compared to hiring professional translators, online platforms can be a more affordable solution for many tasks.
Speed: Instant translation is now a reality, making communication faster than ever.
Continuous Improvement: With each translation, many platforms learn and improve, offering better results over time.
4. Limitations and Challenges
While online translation platforms offer numerous benefits, they are not without limitations:
Lack of Nuance: Translations can sometimes miss cultural nuances or idiomatic expressions.
Data Privacy Concerns: Users might be wary of sharing sensitive information on online platforms.
Over-reliance: Sole reliance on machine translation can lead to miscommunication, especially in critical areas like legal or medical translations.
5. The Future of Online Translation
The future looks promising for online translation platforms. With advancements in AI and machine learning, we can expect even more accurate and context-aware translations. Additionally, augmented reality (AR) might play a role, with real-time translations appearing as overlays in AR glasses.
Moreover, as the world becomes more interconnected, the demand for translation services, both online and offline, will continue to grow. This will drive innovation and competition in the sector, leading to even more advanced and user-friendly platforms.
6. The Role of Human Translators in the Digital Age
Despite the rapid advancements in online translation platforms, the role of human translators remains indispensable. Machines, no matter how advanced, lack the human touch, cultural understanding, and emotional intelligence that human translators bring to the table. Here’s why they remain relevant:
Cultural Sensitivity: Human translators understand the cultural nuances and can interpret context in ways machines can’t. This is especially crucial for content that requires a deep understanding of local customs, traditions, and idioms.
Specialized Fields: Areas like legal, medical, and technical translations often require a specialized knowledge base. Human experts in these fields ensure that translations are not just linguistically accurate but also contextually correct.
Quality Assurance: Many businesses and organizations use a hybrid approach. They combine machine translation for speed and scale with human oversight for quality assurance, ensuring the final output is both fast and accurate.
Platforms like Duolingo and Wikipedia have leveraged the power of the community to drive translations. These crowd-sourced models allow for a diverse set of inputs, often resulting in translations that are both accurate and rich in local flavor.
8. Ethical Considerations in Online Translation
As with all technology, online translation platforms come with ethical considerations:
Bias and Stereotyping: Algorithms can sometimes perpetuate biases present in the data they were trained on. It’s essential to ensure that these platforms are trained on diverse datasets to avoid reinforcing stereotypes.
Job Displacement: While online platforms create new opportunities, there’s also a concern about job displacement in the translation industry. Balancing technological advancement with job preservation is a challenge that the industry must address.
9. Personalized and Adaptive Translation
The future might see translation platforms that adapt to individual users. Just as AI can learn a user’s preferences in music or shopping, future translation tools might adapt to a user’s linguistic style, offering personalized translations based on past interactions.
10. Conclusion: A Collaborative Future
The future of translation is not a choice between humans and machines but a collaboration between the two. Online translation platforms will continue to evolve, becoming more sophisticated and integrated into our daily lives. However, human expertise will always be needed to navigate the complexities of language and culture. Together, humans and technology will work hand in hand to make cross-cultural communication smoother and more accessible to all.