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Ryan Reynolds, Channing Tatum y un gran fin de semana en Wrexham (vía Fat Pig)

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“Bienvenido al Parque Conmemorativo Ryan Reynolds”.

Es un estribillo muy familiar en este rincón de Wrexham desde que a Rob McIlhenny se le ocurrió Una nueva idea para transformar el antiguo Hipódromo de la calle Henplas en un espacio comunitario en honor a su copresidente.

Los equipos están el sábado, aproximadamente tres horas antes de la lucha por el ascenso. Wrexham Empate 2-2 ante el Cambridge United en un partido apasionante Primera LigaEs que el guía que muestra a su acompañante el lugar es el propio hombre. Ah, y el “compañero” de Reynolds en esta ocasión resulta ser su colega Channing Tatum.

Bienvenido a Wrexham, un mundo donde Hollywood y el fútbol de ligas inferiores han chocado tan espectacularmente para que parezca tan completamente normal que Reynolds y Tatum, dos de las estrellas de cine más importantes del mundo, pueden pasear tranquilamente por un popular pub del centro de la ciudad un viernes por la noche para una comida ligera y luego invita a todos los presentes a una pinta festiva.

O cómo Reynolds, al visitar el parque que lleva su nombre la próxima hora del almuerzo, podría alegrar el día del joven fan Jake Morrisroe-Clutton filmando un mensaje de vídeo en el teléfono de su padre a un amigo ausente.


Ryan Reynolds y Channing Tatum filman un mensaje en vídeo para un fan (Richard Sutcliffe/el atleta)

Este es verdaderamente un club donde puedes sentir lo extraordinario todos los días, incluso en una tarde que finalmente terminó en frustración gracias al gol del empate del delantero de Cambridge Dan Nlundolo en el minuto 89 desde el punto de penalti.

“Hablé con Ryan antes del partido y fue fantástico verlo”, dice Phil Parkinson, cuyos jugadores conocieron a Reynolds y sus invitados VIP antes del inicio. “Siempre es un poco especial cuando Ryan está aquí porque es el copropietario del club de fútbol.

“Obviamente estoy en contacto con Rob y Ryan todo el tiempo a través de mensajes de texto y demás, y mensajes en el futuro que quieren ser actualizados todo el tiempo, pero fue bueno tener una conversación y es lamentable que no pudiéramos tenerla. Puntos para él.”

La permanencia de Malky Hollywood en Wrexham puede haber estado marcada principalmente por el éxito gracias a esos ascensos sucesivos, pero la pareja también ha conocido muchos dolores de cabeza, incluida una derrota por 5-4 ante Grimsby Town en los play-offs de la Liga Nacional y la famosa negación de su presencia. . Copa FA Victorioso Sheffield United A través del ecualizador del tiempo de descuento ante las cámaras de la BBC en directo.

Un emocionado Reynolds estuvo al borde de las lágrimas cuando se dirigió a los jugadores en el vestuario después de un empate 3-3 en enero de 2023, por lo que es poco probable que un empate tardío de Cambridge el sábado molestara indebidamente al canadiense.

Sin embargo, fue un recordatorio oportuno de que nada se puede dar por sentado a pesar de un regreso muy alentador a la Liga Uno, ya que Wrexham acumuló 41 puntos en sus primeros 20 juegos.

Los anfitriones fueron culpables de cometer demasiados errores no forzados, particularmente en defensa, donde una unidad normalmente confiable tuvo dificultades para defender a un equipo de Cambridge muy trabajador que arruinó el primer regreso de Reynolds al SToK Cae Ras desde la victoria de la jornada inaugural. Vagabundos de WycombeEl equipo ahora está en lo más alto de la liga.

La ex estrella de Mujeres desesperadas, Eva Longoria, aportó un toque extra de glamour de Hollywood a esa tarde de agosto.mientras que esta vez fue la estrella del Magic Mike Tatum.

La pareja, que se cree que está en el Reino Unido filmando un anuncio para el Super Bowl del próximo año, se ha unido para llevar el recuento de celebridades de Wrexham al siguiente nivel, con el cantante principal de Green Day, Billie Joe Armstrong, y Brandon Sklenar, quien protagonizó It Ends. Con nosotros al… lado de Reynolds. La esposa de Blake Lively.

La diversión comenzó temprano el viernes por la noche cuando Tatum y Sklenar se unieron a Reynolds en The Fat Boar, donde Los jugadores del Wrexham celebraron esos sucesivos ascensos.

Se tuvieron que implementar medidas de seguridad adicionales después de que se difundió rápidamente la noticia de los invitados sorpresa del pub, que llegaron poco después de las 8 p.m. por la entrada trasera. Aproximadamente una hora después, aquellos que esperaban vislumbrar las estrellas cumplieron su deseo cuando Reynolds, Tatum y sus compañeros de equipo terminaron su comida antes de bajar al bar principal.

La estrella de Deadpool luego tomó el micrófono para explicar por qué se acostó temprano. “Tengo cuatro hijos y esta es la noche en la que puedo dormir cuando quiero y estoy muy emocionado por ello”, dijo.

Antes de irse, Reynolds reveló que había invitado a todos en el bar a tomar una copa antes de bromear diciendo que Rich Watkin, copropietario de Fat Boar, “probablemente está llevando en autobús a otras cien personas mientras hablamos, pero está bien”.

hablando con el atleta Después de 24 horas de tormenta, “Durante los últimos cuatro años, la gente ha preguntado si Ryan ha estado alguna vez en un bar”, dijo Watkin. Pero siempre pensé: “No veo cómo puede venir”. Logísticamente, sería una pesadilla.

“Y para ser justos con Ryan, encontró una manera de hacerlo de manera brillante el viernes. Básicamente no tuvimos aviso de que vendría. Solo recibimos la llamada 20 minutos antes de lo programado y funcionó muy bien.

“Una visita como la del viernes fue un recordatorio de lo afortunados que somos como ciudad. Podemos sentirnos un poco miserables. Ryan o Rob están en el escenario y parece completamente normal. Aunque no es nada real.

“Y, sin embargo, de repente Ryan está sentado en tu restaurante y el resto del edificio tiene esta sensación de vida. Ahí es cuando aprecias lo afortunados que somos como ciudad y como club”.

“El revuelo a su alrededor fue increíble, incluso entre los que no son fanáticos del fútbol. No debería haber hecho lo que hizo, bajar a ver a todos. Podría haberse ido por donde llegó, por la puerta trasera.

“Esa fue la parte que realmente me impresionó, porque fue muy fácil hacerlo e irse sin ningún problema. Pero Ryan tomó la decisión de bajar para desearles a todos una Feliz Navidad”.

Reynolds se refrescó temprano en la noche y Tatum se reunió con él a la mañana siguiente en el parque que lleva su nombre como regalo de cumpleaños del copropietario McElhenney. Luego vino una rápida visita al café ucraniano Zerno en High Street antes de que el grupo terminara su mini gira en el pub The Turf, donde el ambiente era seguro de que otro capítulo de la historia de éxito de Wrexham estaba a punto de escribirse frente al club. miembros. -¿Qué pasa contigo?

En cambio, Cambridge rompió el guión con su propio final estilo Hollywood, para frustración de Reynolds y sus colegas.

(Imagen superior: Richard Sutcliffe/The Athletic)



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Doctors Combined a Heart Pump and Pig Kidney Transplant in Breakthrough Surgery

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The kidney used in the latest NYU transplant was procured from a pig with a single genetic edit—the removal of a gene that produces a sugar known as alpha gal. This sugar appears on the surface of pig cells and seems to be responsible for rapid rejection in humans. The pig was engineered by Revivicor, a subsidiary of United Therapeutics Corporation.

Mandeep Mehra, a cardiologist and professor of medicine at Harvard Medical School, is excited by the NYU news. “It’s very innovative to combine the two,” he says, but the heart pump carries a risk of infection. Left ventricular assist devices require external batteries to power them. A wire comes out of the patient’s abdomen and connects to a controller and battery pack. “It’s that exit site that can be prone to infection,” he says.

Mehra says it also remains to be seen whether the single gene edit will be enough to prevent rejection and keep the kidney functioning for the long term. “The entire premise of gene editing was to overcome the immunological barrier,” he says.

Close up of surgeons in organ transplant surgery

PHOTOGRAPH: JOE CARROTTA FOR NYU LANGONE HEALTH

In the previous pig organ transplants in living patients, the animals had more modifications. The pig used for the heart transplants had 10 edits and the one used in Slayman’s procedure last month had 69. Yet with both Bennett’s and Faucett’s hearts, doctors noted signs of rejection. And even a week after Slayman’s surgery, his kidney showed early evidence of rejection—something his medical team hadn’t expected.

“The evolutionary distance between humans and pigs is 100 million years,” Mehra says. “Any gene editing needs to overcome that.”

The NYU’s team is taking a “less is more” approach with gene editing, Montgomery said, and instead relying on the pig’s thymus to help mediate the immune mismatch.

Pisano says she’s glad she took a chance on the procedure. She hopes she can leave the hospital so she can go shopping and play with her grandchildren. “The worst case scenario is that it doesn’t work,” she says, but even then she thinks it would be worthwhile. “It might work for the next person.”

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He Got a Pig Kidney Transplant. Now Doctors Need to Keep It Working

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Other than rejection of the organ, one of the most common transplant complications is infection. Doctors have to strike a balance when prescribing immunosuppressive drugs: too low a dose can lead to rejection, while too much can make a patient vulnerable to infection. Immunosuppressants are powerful drugs that can cause a range of side effects, including fatigue, nausea, and vomiting.

Despite the deaths of the two pig heart recipients, Riella is optimistic about Slayman’s transplant. For one, he says, Slayman was relatively healthy when he underwent the surgery. He qualified for a human kidney but because of his rare blood type he would likely need to wait six to seven years to get one. The two individuals who received pig heart transplants were so ill that they didn’t qualify for a human organ.

In addition to close monitoring and traditional immunosuppressants, Slayman’s medical team is treating him with an experimental drug called tegoprubart, developed by Eledon Pharmaceuticals of Irvine, California. Given every three weeks via an IV, tegoprubart blocks crosstalk between two key immune cells in the body, T cells and B cells, which helps suppress the immune response against the donor organ. The drug has been used in monkeys that have received gene-edited pig organs.

Hospital patient

Photograph: Massachusetts General Hospital

“It’s pretty miraculous this man’s out of the hospital a couple of weeks after putting in a pig kidney,” says Steven Perrin, Eledon’s president and chief scientific officer. “I didn’t think we would be here as quickly as we are.”

Riella is also hopeful that the 69 genetic alterations made to the pig that supplied the donor organ will help Slayman’s kidney keep functioning. Pig organs aren’t naturally compatible in the human body. The company that supplied the pig, eGenesis, used Crispr to add certain human genes, remove some pig genes, and inactivate latent viruses in the pig genome that could hypothetically infect a human recipient. The pigs are produced using cloning; scientists make the edits to a single pig cell and use that cell to form an embryo. The embryos are cloned and transferred to the womb of a female pig so that her offspring end up with the edits.

“We hope that this combination will be the secret sauce to getting this kidney to a longer graft survival,” Riella says.

There’s debate among scientists over how many edits pig organs need to last in people. In the pig heart transplants, researchers used donor animals with 10 edits developed by United Therapeutics subsidiary Revivicor.

There’s another big difference between this procedure and the heart surgeries: If Slayman’s kidney did stop working, Riella says, he could resume dialysis. The pig heart recipients had no back-up options. He says even if pig organs aren’t a long-term alternative, they could provide a bridge to transplant for patients like Slayman who would otherwise spend years suffering on dialysis.

“We’ve gotten so many letters, emails, and messages from people volunteering to be candidates for the xenotransplants, even with all the unknowns,” Riella says. “Many of them are struggling so much on dialysis that they’re looking for an alternative.”

The Mass General team plans to launch a formal clinical trial to transplant edited pig kidneys in more patients. They received special approval from the US Food and Drug Administration for just one procedure. For now, though, their main focus is on keeping Slayman healthy.

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First pig liver transplanted into a person lasts for 10 days

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A shopkeeper holds a Bama miniature pig in a cafe offering customers relaxing access to the pet pigs in a shopping mall in Shanghai, China.

Organs from genetically modified pigs could help keep patients alive while they are awaiting a human donor.Credit: Feature China/Future Publishing via Getty

In a milestone for the transplantation of animal organs into people, a 50-year-old clinically dead man in China has become the first person to receive a liver from a pig. With consent from the man’s family, researchers stitched the organ, from a genetically engineered miniature pig, to the man’s blood vessels, where it remained for ten days. It has been surgically removed today, says Dou Kefeng, one of the surgeons who led the transplant at Xijing Hospital of the Air Force Medical University in Xi’an. “Our study has just been terminated, and the colour and texture of the pig liver [transplant] are generally normal.”

The procedure was intended to test whether genetically modified pig organs could one day be used to supply hospitals for transplants. In China alone, hundreds of thousands of people experience liver failure every year, but only around 6,000 received a liver transplant in 2022. In the past few years, surgeons in the United States have transplanted pig hearts into two living people, and transplanted hearts and kidneys to several people declared dead because they lack brain function.

The Xijing surgeons say the pig liver secreted more than 30 millilitres of bile every day, a sign that it was functioning.

Researchers who specialize in transplanting animal organs into people, known as xenotransplantation, are eager to see more details about the procedure’s safety and functional benefits, and to learn from the work.

“This is a really exciting study,” says Ping Li, a transplant researcher at Indiana University School of Medicine in Indianapolis.

Important insights

The surgery marks the first time a pig liver has been transplanted into a human. However, in January, a team led by transplant surgeon Abraham Shaked at the University of Pennsylvania in Philadelphia connected a clinically dead person to a genetically modified pig’s liver located outside their body. The organ circulated the person’s blood for three days.

It is “heart-warming” to see researchers pursuing xenotransplantation all over the world, says Muhammad Mohiuddin, the surgeon and researcher who led the pig-heart transplants in living people. “It’s an expensive process, but it has a huge amount of potential,” says Mohiuddin, who is at the University of Maryland School of Medicine in Baltimore and is president of the International Xenotransplantation Association.

Luhan Yang, chief executive of Qihan Biotech in Hangzhou, China, which is developing gene-edited pigs as a source for organs, says she expects more xenotransplants in clinically dead people or — for compassionate reasons — in terminally ill people in the United States, China and Europe in the coming years.

The Chinese study will offer important insights into whether pig-liver transplants can keep people alive, even just for a few days, says David Cooper, a xenotransplant immunologist at Massachusetts General Hospital in Boston.

Ten days

On 10 March, the Xijing Hospital team, including Dou, Tao Kaishan and Wang Lin transplanted a pig liver weighing 700 grams into the donor, who lacked cognitive function. The surgery took roughly nine hours to perform. The donor received a daily regimen of immunosuppressive drugs, and his original liver was left in place.

The liver came from a Bama miniature pig (Sus scrofa domestica) bred by the company Clonorgan Biotechnology in Chengdu, China. It contained six genetic modifications, says Wang. These deactivated three genes for proteins found on the surface of pig cells and introduced three genes for human proteins, to prevent the donor from rejecting the pig organ.

Dou says the pig was bred in a specialized pathogen-free facility and tested negative for about a dozen pathogens, including Streptococcus suis, the type-2 strain of Mycoplasma pneumoniae and porcine cytomegalovirus. So far, he has not seen signs of an immediate form of organ rejection and the liver is producing bile. “This is encouraging,” says Cooper.

The researchers have also taken daily blood samples and liver biopsies and will assess immune response, infection risk and liver function in detail. “We’re having a pathologist evaluate if there’s acute rejection,” says Dou.

The surgery was approved by the recipient’s family and several university committees, says Wang. “It has been strictly carried out according to relevant national and international regulations.”

Temporary fix?

The researchers plan to repeat the procedure in another clinically dead person later this year — and next time they will remove the person’s existing liver.

Mohiuddin points out that although clinically dead people are a useful model for assessing the viability of xenotransplantation in living people, that usefulness is limited, because once a person’s brain ceases activity, they undergo hormonal changes. And it isn’t yet clear how long someone with no cognitive function can be maintained on a ventilator and with a donated pig organ, he says. The longest documented case was two months, which involved a pig-kidney transplant.

Shaked also questions whether surgery is necessary for pig livers to be useful to humans. Unlike the heart, which essentially functions as a pump, the liver performs many complex tasks, which makes it particularly difficult to transplant. A pig liver can carry out the liver’s detoxifying and waste-disposal role, but Shaked does not anticipate that it will be able to produce the broad array of proteins required for the human liver’s other functions.

This means that whereas heart and kidney xenotransplants have been touted as possible long-term organ replacements, liver xenotransplants are seen mainly as a short-term fix for people with liver failure. They could enable a person’s existing liver to regenerate, for example after damage caused by alcohol or drug consumption, or could buy time while waiting for a human liver donor.

As a result, Shaked and his team chose to avoid operating: they hooked up an external pig liver to the recipient using blood-carrying tubes. But Dou says his team’s goal is organ replacement. He adds that working in a person allows the researchers to collect a lot more data, including information on immunology and physiological changes.

Yang says she hopes the team will publish detailed insights about the transplantation in peer-reviewed publications, to help determine which approach is more feasible.

In the meantime, Shaked hopes to exchange notes with the Chinese team. “I’d love to hear more about what they did. It’s fantastic.”

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