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The neuroscientist formerly known as Prince’s audio engineer

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Prince performs onstage during the 1984 Purple Rain Tour

Musician Prince on stage in Detroit, Michigan, during his 1984 Purple Rain tour.Credit: Ross Marino/Getty

Working scientist profiles

This article is part of an occasional Nature series in which we profile scientists with unusual career histories or outside interests.

In 1983, Susan Rogers got a call that would change her life. She was working as an audio technician in the music industry in Los Angeles, California, when an ex-boyfriend got in touch to tell her that the musician Prince was looking for a technician.

Rogers, who at the time was one of the few female audio technicians in the United States — and maybe even the world — was already a Prince fan. His work reminded her of the soul music she had grown up listening to in the 1960s and 1970s in southern California — artists such as Sly and the Family Stone and Al Green, but with a contemporary, punk edge.

By this point, Prince had just released his album 1999. Rogers, who was 27 at the time, would begin working with him on Purple Rain, the record that would launch him into global superstardom.

She spent four years working with Prince in his home recording studio in Minneapolis, Minnesota, leaving a year before the opening of Paisley Park, Prince’s now-legendary creative and performing space. By this point, she had graduated from being an audio technician — maintaining and repairing equipment — to recording engineer, a role that has much more influence over the whole sound of a record.

“I was talking to some Prince alumni recently and they were saying ‘poor Susan, she never even got Christmas Day off’. There’s no ‘poor Susan’ about it — I was working with my favourite artist and there was nowhere I would rather be,” she says.

After Prince, she went on to work with other musicians, such as the Canadian rock group Barenaked Ladies and David Byrne, former lead singer of the new-wave band Talking Heads. At the age of 44, and with the help of the royalties she earned on the Barenaked Ladies album Stunt, she quit the music industry (see ‘Quick-fire questions’).

Higher education had not been an option growing up — her mother died when she was 14 and Rogers was married aged 17. She escaped that unhappy relationship after three years and headed to Hollywood, where she got a job as a trainee audio technician.

Susan Rogers works at FAME Studios

Susan Rogers trained as a recording engineer before pivoting to neuroscience. She continues to produce music, such as for US singer-songwriter Jeff Black.Credit: Madison Thorne

Over the years, she increasingly felt the pull of academia and a calling to study the natural world. So, in 2000, she began her undergraduate degree in neuroscience and psychology at the University of Minnesota. Initially, she wanted to study consciousness in non-human animals, but was advised that a more meaningful contribution would be a neuroscience degree that would also enable her to study music perception and cognition. She then did her doctoral work at McGill University in Montreal, Canada. Returning to education after so many years was not as difficult as she had feared — and years spent learning the intricacies of a recording console helped her to understand the complexity of the human brain.

Her PhD research focused on auditory memory. She designed experiments to test short-term memory for musical intervals, in which musicians and non-musicians listened to a piece of music containing consonance (harmonious sounds) and dissonance (clashing or unexpected sounds). The most interesting observation was that, for both groups, short-term auditory memory lasted longer than was previously thought, she says. At the time of her doctoral work, psychologist István Winkler and his colleagues had reported that auditory short-term memory persisted for roughly 30 seconds1, but Rogers’s work demonstrated it lasting for 48 seconds.

A good ear and a sound work ethic

One of Rogers’s PhD supervisors was Daniel Levitin, a cognitive psychologist, musician and record producer whose research focuses on music perception. He knew of Rogers from her work with Prince and Barenaked Ladies, and took her on “in a heartbeat”. “She was Prince’s engineer — that’s one of the top engineering jobs in the world,” he says.

Her years in the music industry greatly enhanced her academic work, he says. It gave her an astonishing work ethic and helped her to hone her all-important listening skills.

“What auditory neuroscience requires is a good ear. You’re designing experiments and you need to be able to hear subtle details that others might not hear so that you know you’ve prepared your experiments correctly. Susan has a great ear.”

Levitin describes her as very musical, “even though she doesn’t play an instrument”. As a producer, he explains, her job was to coax out of the musician “the most authentically emotional performance you could get”. “Miles Davis told her she was a musician. He didn’t throw around that term lightly,” he says of the renowned jazz bandleader and composer.

In 2008, Rogers joined Berklee College of Music in Boston, Massachusetts, where she teaches music production and engineering. She is also writing a course on music and neuroscience for the college’s online programme.

She has investigated what people visualize when they listen to music, and plans to publish the results. Some people, including Rogers, imagine the musicians playing; others make up stories based on the lyrics; and for some — particularly older people — music triggers memories. Interestingly, musicians and non-musicians do not differ greatly in their visualizations.

“One of the least musical people that I know — somebody who would almost be called tone deaf — reports that he sees abstract shapes and colours when he listens to music. And two of the finest musicians I know also visualize abstract shapes and colours. I can’t even imagine having that visualization to music,” she says.

Throughout her successful music career, Rogers admits that there were times when she felt like a bystander in the studio — because she does not play an instrument or compose, her views felt secondary to those of the professional musicians. But in her career as an academic and teacher, she is very much at home.

“Nothing in my life has brought me more joy than scientific pursuit. It is as creative as anything I ever did while making records. Had I realized in my youth that a career in science was possible for me, my hunch is that I could have made a more notable contribution. Earning a PhD at age 52 doesn’t permit that,” she says.

Common cause

Rogers also thinks that musicians and scientists have more in common than one might guess — both need to be open-minded and be able to separate relevant and irrelevant information. “The fashion and the hairstyles are different — musicians have the edge there — but there are more similarities than differences,” she says.

How else are the two professions similar? “It takes guts to commit to a music career because there is no comfortable path and absolutely no light to guide you, other than your own internal one,” says Rogers. “I’ve had the privilege of knowing some outstanding scientists and my perception is that they, too, are driven more by scratching an intellectual itch than by winning a prize or being famous.”

That feeling of being a bystander in the music industry receded when she realized that listening is an “indispensable component of what music is”, as she explains in her 2022 book, co-authored with neuroscientist Ogi Ogas, This is What it Sounds Like: What the Music You Love Says About You.

“Practically speaking, without a listener, music does not exist. By perceiving, feeling and reacting to the many dimensions of a song, a listener closes the creative circle and completes the musical experience,” she writes.

Levitin thinks that one of Rogers’s main contributions through her writing and public speaking has been to elevate the importance of the listener.

“She’s also adding the social context by which we listen, and by which we decide what we like, and the developmental stages we go through as listeners, from listening to children’s nursery rhymes to more sophisticated things,” he says. Her book, he adds, is a perfect example of what a popular-science work and science communication should be — it does not dumb down the science or patronize its audience, but neither does it aim so high that it’s impenetrable.

Rogers hopes that, one day, all music courses will include a unit on music cognition to help creators to understand how listeners receive their craft.

“It won’t help you in the studio and it won’t help you while you’re composing. And I don’t think it should — when we’re creating works of art, we shouldn’t be thinking too deeply about the nuts and bolts,” she says. That said, a music-cognition course can help music creators to understand their audiences, “just like a chef needs to understand what food tastes like”, she adds.

When she finally left Prince and began working with other musicians, she felt she had to unlearn some elements of Prince’s intense working habits.

“Prince was doing a song a day when I was with him. That was every day. That’s how we worked,” she says.“He also had an exceptional ear for arrangement. He could foresee how the end product was going to turn out in such a way that each part — drums, bass, guitars, keyboards, backing vocals — was recorded with an ear for the subsequent parts. He had a watchmaker’s skill of putting the individual parts together to create a whole.”

She still loves listening to music and discovering new artists, particularly with the help of her students, but she remains true to soul, her first musical love.

“As Prince used to say, soul is the street I live on,” she says.

Quick-fire questions

What music do you listen to when working?

I can’t have music on in the background because it’s such a powerful attractor. If something comes on the radio while I’m driving, I have to turn it down and remind myself to pay attention to the road.

What has been your career highlight?

Working with Prince was obviously a great star in the firmament. But being the producer on the Barenaked Ladies album Stunt was amazing — it went multi-platinum. I’ve had a short science and teaching career but receiving a distinguished teaching award at Berklee was also gratifying.

Did you ever speak to Prince about your research?

Sadly, no. The last conversation I had with Prince was around 1997, before my university education. If we’d had a chance to talk about my research, he would have argued with me on every point, which would have been welcome. I heard him say that if he’d gone into something other than music, he would have liked teaching. With his creativity, intelligence and self-discipline, he would have been an outstanding researcher.

Do you have a memorable mentor?

Musically, the producer Tony Berg taught me a lot. He hasn’t sold as many records as others, but he has influenced so many people. Stephen McAdams at McGill University would be my scientific mentor — he took over supervising my PhD because Daniel Levitin was on a book tour. He is a world expert on timbre perception and is everything a scientist should be — kind, generous of spirit, funny.

Is there any music you don’t enjoy listening to?

I used to have zero interest in heavy-metal music, but two of my students shared their love of it with me, and, as good listeners, they explained why it was so great. I picked up on their love for it. Sometimes we don’t like something because we don’t know it well enough.

If you could save only one record from your collection, what would it be?

It’s so hard to choose when you love so many things, but just off the top of my head I’d probably choose Al Green’s Greatest Hits album.

This interview has been edited for length and clarity.

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Roger Guillemin (1924–2024), neuroscientist who showed how the brain controls hormones

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Black and white portrait of Roger Guillemin pictured in 1977

Credit: Hulton Archive/Getty

Roger Guillemin identified the molecules in the brain that control the production of hormones in endocrine glands such as the pituitary and thyroid. His work led to a torrent of advances in neuroendocrinology, with far-reaching effects on studies of metabolism, reproduction and growth. For his discoveries on peptide-hormone production in the brain, Guillemin shared the 1977 Nobel Prize in Physiology or Medicine with Andrew Schally and Rosalyn Yalow. He has died at the age of 100.

In the autumn of 1969, after analysing millions of sheep brains for more than a decade, Guillemin and his colleagues determined the structure of thyrotropin-releasing factor (TRF). This small peptide is produced in the hypothalamus, a small region at the base of the brain, and is transported to the anterior lobe of the nearby pituitary gland, where it triggers the release of the hormone thyrotropin. Thyrotropin, in turn, stimulates the thyroid gland to produce the hormone thyroxine, which regulates metabolic activity in nearly every tissue of the body. More than two dozen drugs use such hypothalamic hormones to treat endocrine disorders and cancers, and the worldwide market for these drugs is worth several billion dollars.

Guillemin was born in Dijon, France, and came of age at the end of the Second World War. He graduated from medical school in the University of Lyon, France, in 1949 and worked as a country doctor in the small commune of Saint-Seine-l’Abbaye in Burgundy. He found the work satisfying but intellectually limiting, noting that “in those days I could take care of all my patients with three prescriptions, including aspirin”. Fascinated by how the brain and pituitary gland control the body’s response to stress, he attended lectures in Paris by the Hungarian–Canadian endocrinologist Hans Selye, after which Selye accepted Guillemin’s request to spend a year doing research in his laboratory at the University of Montreal, Canada.

This turned into a four-year project, for which Guillemin was awarded a PhD in 1953. His studies with Selye were impactful, but it was meeting the UK physiologist Geoffrey Harris in Canada that would shape Guillemin’s subsequent science. Harris argued that the hypothalamus controls the anterior pituitary not through nerve signals, but rather through blood-borne factors that reach the pituitary through the capillaries of an interconnecting stalk. Recruited to the faculty of the Baylor College of Medicine in Houston, Texas, Guillemin decided to tackle Harris’s hypothesis head on. His initial aim was to purify and determine the structure of corticotropin-releasing factor (CRF), the hypothalamic hormone that stimulates the anterior pituitary to produce adrenocorticotropic hormone, the driver of the stress response described by Seyle. Progress towards this goal was slow, so Guillemin turned his attention to other putative releasing factors, including TRF.

The scale of his efforts at purification in the late 1950s and 1960s was enormous. These releasing factors were peptides — short chains of amino acids — present in only tiny amounts in the hypothalamus. Together with the fact that the hypothalamus is itself a small part of the brain, this meant that purification began with extracts prepared from millions of sheep hypothalami obtained from slaughterhouses. Peptides were separated on 3-metre-tall chromatography columns that extended through the lab’s ceiling. One set of columns was packed with the then-new resin Sephadex, released by the Stockholm-based biotechnology company Pharmacia in 1959. Guillemin sent a postdoc in his lab, Andrew Schally, that year to Sweden to procure much of the world’s supply of Sephadex.

Schally, who had worked on releasing factors for his PhD, joined the expanding team in Houston in 1957. He chafed under Guillemin’s leadership, however, viewing his years in Houston as a struggle in which he and Guillemin had a “very bitter, unpleasant relationship”. Guillemin suggested that Schally should move on, and himself accepted a simultaneous appointment at the Collège de France in Paris in 1960. Schally established his own competing research operation at Tulane University in New Orleans, Louisiana. Guillemin and Schally would remain competitors for more than two decades, a state of affairs not changed by their shared Nobel Prize.

The Houston and New Orleans teams succeeded in purifying TRF and determining its amino-acid sequence at around the same time. Immediately thereafter, Guillemin moved his lab to the Salk Institute for Biological Studies in La Jolla, California. There, his team identified a raft of hypothalamic releasing factors, now referred to as hormones. These included gonadotropin-releasing hormone, which drives the release of hormones that stimulate the reproductive organs; somatostatin, which inhibits the release of growth hormones; and growth-hormone-releasing hormone. In 1981, a Salk Institute team headed by US endocrinologist Wylie Vale, who was a student of Guillemin, finally purified and sequenced the elusive CRF, Selye’s obsession and Guillemin’s initial target from the 1950s. Drugs built on these discoveries have proved to be among the farthest-reaching medical translations of research from the institute.

Guillemin was the recipient of multiple honours and awards as well as the Nobel Prize. He was a connoisseur of the wines of Burgundy, and during his tenure as president of the Salk Institute in 2007–09, white wine was served at lunchtime faculty meetings. Roger lived an art- and music-filled life, and was close to the artists Françoise Gilot and Niki de Saint Phalle. He cherished his ties to family, students, postdocs, colleagues and friends. He leaves a vibrant scientific legacy.

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